Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases

Schmidt–Erfurth, U.

doi:10.1167/iovs.05-0370

Cited by 258 publications

(134 citation statements)

References 38 publications

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“…Recently, a report was published that showed the use of FD OCT to create volumetric representations of various macular lesions, which is an extension of the technique we have illustrated in this article. 16 Other reports have been published which demonstrate similar mapping techniques using time-domain OCT. 17,18,28 In those time-domain models, however, the map was created from a series of C-scans, a potential weakness of which is that most clinicians rely on B-scans for evaluation of the retina. Therefore, high-quality B-scans are more desirable than C-scans.…”

Section: Discussionmentioning

confidence: 83%

“…A report utilizing this technology to create volumetric representations of retinal lesions has recently been published. 16 In this paper, we describe a technique that can be applied to OCT imaging to produce more detailed retinal maps. It involves performing a rapid sweep of serial OCT B-scans through the macula, analogous to a modern computed tomography scanner.…”

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confidence: 99%

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Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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Purpose: To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.Design: Prospective observational case series. Participants: Five patients with a variety of macular pathologies. Methods: Patients were imaged with a Fourier-domain high-speed high-resolution OCT system built at our institution. A sweeping serial OCT B-scan of the macula was acquired to create a detailed retinal structural map. The data were then used to make individual clinical observations.Results: Rapid serial OCT B-scans produced detailed macular maps for all 5 patients. Diagnoses of imaged patients included macular hole, lamellar macular hole, regressed macular hole or macular microhole, choroidal neovascular membrane (CNV) from age-related macular degeneration, and CNV from presumed ocular histoplasmosis syndrome. Reconstructed B-scans and C-scans are shown for selected patients to illustrate the additional perspectives gained by obtaining a detailed retinal map.Conclusions: Rapid serial Fourier-domain OCT B-scanning can be used to create a detailed retinal structural map. This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.

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Section: Discussionmentioning

confidence: 83%

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confidence: 99%

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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“…Further improvements in visualisation of intra-and subretinal morphology, [32][33][34] advances in the understanding of anatomic correlates as well as refinements of measurements 35,36 are anticipated and may enhance the analysis of retinal images in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration

Joeres

Llacer

Heussen

et al. 2007

Eye

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Purpose To analyse structural changes after autologous translocation of choroid and retinal pigment epithelium (RPE) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT). Methods We performed a prospective nonrandomised study in 29 consecutive patients, who underwent submacular surgery with translocation of an autologous fullthickness graft of RPE, Bruch's membrane, and choroid. All patients had recent loss of reading vision due to AMD. OCT was performed before surgery and at 3-and 6-month follow-up to analyse the morphological appearance of the graft and the overlying retina. Results Maximum retinal thickness decreased from mean 408 lm (standard deviation (SD) 127 lm) preoperative to mean 373 lm (SD 104 lm) at 6-month follow-up (P ¼ 0.094). In 11 cases (40%), a nearly physiological shape of the retina was seen at this time point. A macular hole persisted in two eyes after silicone oil removal. In most eyes, the highly reflective band of the graft presumably corresponding to RPE was continuous with the surrounding RPE band in all six OCT scans. Eyes with flat appearance of the graft at 6-month follow-up (o300 lm) showed a significantly better functional outcome than eyes with more prominent grafts. Interestingly, most patients did not complain about metamorphopsia, even though the graft was prominent or wrinkled in some cases. Conclusion OCT is a useful tool in monitoring intra-and subretinal changes after subretinal surgery with graft translocation. We demonstrated that graft translocation may lead to a normalisation of retinal thickness and stabilisation of visual acuity.

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“…It is also the key to imaging large comprehensive 3 D volumes [173] or to the time-resolved observation of dynamic processes [44,45,167]. The recent commercialization of high speed line cameras and swept sources will therefore be an important factor driving the development of the next generation of OCT systems.…”

Section: Developments In Ophthalmic Octmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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Three-Dimensional Ultrahigh-Resolution Optical Coherence Tomography of Macular Diseases

Abstract: High-speed UHR OCT offers unprecedented, realistic, 3-D imaging of ocular diseases at all epi-, intra- and subretinal levels. A complete 3-D data set of the macular layers allows a comprehensive analysis of focal and diffuse diseases, as well as identification of dynamic pathomechanisms.

Cited by 258 publications

References 38 publications

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration

Optical coherence tomography—current technology and applications in clinical and biomedical research

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