Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice

Li, Koukou; Yu, Min; Hu, Yang; Ren, Guoqing; Zang, Tingting; Xu, Xiuhong; Qu, Juanjuan

doi:10.1016/j.cbi.2016.01.013

Cited by 25 publications

(13 citation statements)

References 48 publications

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“…The major pharmacological ingredients of mushrooms in the Ganoderma genus include Ganoderma polysaccharides and ganoderic acids, and in particular, it has been reported that Ganoderma polysaccharides have some special functions such as therapeutic effects on cancer 5 – 7 , obesity 8 , 9 , diabetes 10 , 11 , and pancreatitis 12 ; as well as pharmaceutical activity on immune modulation 13 – 17 , liver protection 4 , 18 , 19 , and vascular endothelial cell growth inhibition 20 , 21 . Especially, it has been reported that β-glucans in Ganoderma are closely related to health, for they can stimulate the immune response through cytotoxic or immunomodulatory mechanisms to enhance cellular immunity, and stimulate a variety of immune cells including macrophages 22 – 24 , neutrophils 25 , 26 , natural killer cells 27 , 28 and dendritic cells 29 , 30 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy

et al. 2018

Sci Rep

134

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Ganoderma lingzhi (G. lingzhi), G. sinense, G. applanatum, etc. belongs to the Ganoderma genus of polypore mushrooms which contain rich polysaccharides valuable for nutrition and positive medicinal effects. In order to evaluate polysaccharide content in Ganoderma mycelia obtained in the fermentation process quickly and accurately, in this work we employed infrared spectroscopy to examine different Ganoderma stains of samples from diversified sources. Through mid-infrared (mid-IR) spectroscopy, we could identify the most relevant spectral bands required for polysaccharide evaluation, and through near-infrared (NIR) spectroscopy, we could establish the quantification model for making satisfactory prediction of polysaccharide ingredient content. As such, we have achieved an effective and convenient approach to quantitative assessment of the total polysaccharides in Ganoderma mycelia but also demonstrated that infrared spectroscopy can be a powerful tool for quality control of Ganoderma polysaccharides obtained from industrial production.

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Section: Introductionmentioning

confidence: 99%

Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy

et al. 2018

Sci Rep

134

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“…It may involve a direct regulation of smooth muscle cells of the stomach to exert multiple, region-specific effects on gastric motility [ 38 ]. Ganoderma lucidum polysaccharides have potent activity in relieving chronic pancreatitis-induced abdominal pain, which could be associated with reduced production of inflammatory cytokines such as interleukin-1 beta (IL-1 β ) and interferon-gamma (INF- γ ) [ 39 ]. Glycycoumarin, a known component of Radix Glycyrrhizae, exhibits potent antispasmodic activities on the smooth muscle of the mouse jejunum.…”

Section: Resultsmentioning

confidence: 99%

Chinese Herbal Medicine for Functional Abdominal Pain Syndrome: From Clinical Findings to Basic Understandings

Liu

Wang

Zhang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Functional abdominal pain syndrome (FAPS) is one of the less common functional gastrointestinal disorders. Conventional therapy has unsatisfactory response to it so people turn to Chinese medicine for help. Currently, we reviewed the whole picture of Chinese herbal medicine (CHM) clinical and basic application in the treatment of FAPS, especially the traditional Chinese medicine (TCM) syndrome, the single herb, and Chinese medicine formulae, thus to provide a solid base to further develop evidence-based study for this common gastrointestinal complaint in the future. We developed the search strategy and set the inclusion and exclusion criteria for article search. From the included articles, we totally retrieved 586 records according to our searching criteria, of which 16 were duplicate records and 291 were excluded for reasons of irrelevance. The full text of 279 articles was retrieved for detailed assessment, of which 123 were excluded for various reasons. The number one used single herb is Radix Ginseng. The most common syndrome was liver qi depression. The most frequently used classic formula was Si-Mo-Tang. This reflected the true situation of clinical practice of Chinese medicine practitioners and could be further systematically synthesized as key points of the therapeutic research for FAPS.

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“…Secondary metabolites isolated from Ganoderma and their biological significance are unclear. In fact, there is a recent study revealing 10 . Koukou Li et al found out that Polysaccharides of Ganoderma lucidum strain S3 (GLPS3) have antioxidative and immunomodulatory activities.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma Lucidum Induced Acute Pancreatitis in The Elderly

Yüksel

Gezer

Gümüş

et al. 2017

Turkish Journal of Family Medicine and Primary Care

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Ganoderma lucidum ( Japoncada'da Reishi, Çince'de Lingzhi) popüler bir tıbbi mantardır ve Çin tıbbında yaklaşık 2.000 yıldır kullanılmaktadır Son 30 yılda, bu mantarlar, modern farmakologlar tarafından incelenmiştir . Pek çok çalışma, G. lucidum'un immün fonksiyonları düzenlediği ve tümör büyümesinin engellenmesinde etkili olduğunu göstermiştir. Bu etkilerin dışında G. lucidum ayrıca hipertansiyon, hiperlipidemi, diyabet, nefrit, astım, arterit, iltihaplı bağırsak hastalıkları ve diğer hastalıkların tedavisinde de kullanılabilir olduğu gösterilmiştir. Bu etkilerin belli mekanizması hala belirsizdir. Bu nedenle, G. lucidum bir terapötik madde olarak tavsiye edilmez. Çoğunlukla, bir bağışıklık arttırıcı ve sağlık için ek gıda olarak kullanılır. Bu olgu sunumunda, farklı klinik bulgularla kliniğimize başvuran akut pankreatitli bir olgu sunulmuştur.

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Three kinds of Ganoderma lucidum polysaccharides attenuate DDC-induced chronic pancreatitis in mice

Cited by 25 publications

References 48 publications

Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy

Assessment of Polysaccharides from Mycelia of genus Ganoderma by Mid-Infrared and Near-Infrared Spectroscopy

Chinese Herbal Medicine for Functional Abdominal Pain Syndrome: From Clinical Findings to Basic Understandings

Ganoderma Lucidum Induced Acute Pancreatitis in The Elderly

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