Three new amides from Streptomyces sp. H7372

Abstract

As amidas fenatato de metila (1), actifenamida (2) e 1-b-D-glucopiranosídeo-actinofenol (3), juntamente com outros 13 compostos de estruturas conhecidas, foram isolados do extrato de uma cultura de Streptomyces sp H7372. As estruturas destes compostos foram determinadas por análises de RMN uni e bidimensionais e por espectrometria de massas. Cicloheximida (6) Three new amides, methyl phenatate A (1), actiphenamide (2) and actiphenol 1-b-Dglucopyranoside (3), along with thirteen known compounds, were isolated from the organic extract of a fermentation culture of Streptomyces sp. H7372. The structures were elucidated by spectroscopic methods including 1D-and 2D-NMR techniques, and MS analyses. Cycloheximide (6) and cyclo(DAla-L-Val) (8) gave a clear zone of inhibition of Ras-Raf-1 interaction in the yeast twohybrid assay which showed high potency with 10 and 25 mm clear ZOIs on SD His -and inactive on SD His + at 2.5 mg per disk, respectively.

Microbiological Aspects of Unique, Rare, and Unusual Fatty Acids Derived from Natural Amides and Their Pharmacological Profile

“…The filamentous fungus Alternaria alternata, which produce various toxins and c disease in various plants such as Japanese pear, strawberry, and mandarin produced toxin, AF-toxin, and ACT-toxin, respectively, and contained (R,2E,4Z,6E)-8-hydro ((R)-2-methyloxiran-2-yl)-octa-2,4,6-trienoic acid (128) and (R,2E,4E,6E)-8-hydroxy-8 2-methyloxiran-2-yl)-octa-2,4,6-trienoic acid (129) [146][147][148]. Methyl phenatate A wit (130) was detected in the organic extract of a fermentation culture of Streptomyce H7372 [149].…”

“…Methyl phenatate A with FA (130) was detected in the organic extract of a fermentation culture of Streptomyces sp. H7372 [149].…”

DIKETOPIPERAZINE PRODUCED BY PSYCHROPHILIC YEAST Glaciozyma antarctica PI12

“…[19]. [22,23], Pseudomonas aeruginosa [18] and Lysobacter capsici AZ78 [24]. The difference between Compound 2 and Compound 3 lay on C-4`, where Compound 2 had a hydroxy at C-4` (Figure 2).…”

Cyclobutastellettolides A and B, C19 Norterpenoids from a Stelletta sp. Marine Sponge

“…Five methyl singlets at δ H 1.04, 1.17, 1.36, 1.40, and 1.61 in the 1 H NMR spectrum of 1 suggested the terpene nature of 1. The analysis of the 1 H, 13 C NMR, DEPT, and HSQC spectra of 1 revealed, in addition to five methyls, five methylene and one methine group as well as eight nonprotonated carbon atoms, including four oxygenated ones (δ C 101.1, 174.8, 208.1, 214.3) (Table 1).…”