Three New Azaphilone Phytotoxins from Coculture of the Phytopathogens Nigrospora oryzae and Colletotrichum gloeosporioides and Antifungal Activities Against N. oryzae

Wu, Ya-Mei; Yang, Xue‐Qiong; Li, Shiyu; Sun, Li-Jingfei; Cen, Rong-Huan; Zhao, Li‐Xing; Yang, Ya‐Bin; Ding, Zhong‐Tao

doi:10.1007/s10600-022-03814-7

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Compound 9 is known as an anthelmintic compound showing selective inhibition of complex I in helminth mitochondria [48]. In addition to anthelmintic activity, compound 9 exhibited antibacterial activity against Escherichia coli, as well as other antimicrobial properties which address ecological and environmental concerns [45,54,55,59]. Surprisingly, in previous studies compound 9 showed no cytotoxicity against several cancer cell lines, including mouse lymphoma L5178Y cell line at 28 µM [29], human cervical HeLa, colon HCT-116, breast MCF-7, lung A549, and leukemia K562 and HL-60 cancer cell lines at 50 µM [60].…”

Section: Antiproliferative Activity Of Isolated Compounds Against Thr...mentioning

confidence: 99%

Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii

Sirimangkalakitti,

Lin,

Harada

et al. 2024

Molecules

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The fungal genus Trichoderma is a rich source of structurally diverse secondary metabolites with remarkable pharmaceutical properties. The chemical constituents and anticancer activities of the marine-derived fungus Trichoderma lixii have never been investigated. In this study, a bioactivity-guided investigation led to the isolation of eleven compounds, including trichodermamide A (1), trichodermamide B (2), aspergillazine A (3), DC1149B (4), ergosterol peroxide (5), cerebrosides D/C (6/7), 5-hydroxy-2,3-dimethyl-7-methoxychromone (8), nafuredin A (9), and harzianumols E/F (10/11). Their structures were identified by using various spectroscopic techniques and compared to those in the literature. Notably, compounds 2 and 5–11 were reported for the first time from this species. Evaluation of the anticancer activities of all isolated compounds was carried out. Compounds 2, 4, and 9 were the most active antiproliferative compounds against three cancer cell lines (human myeloma KMS-11, colorectal HT-29, and pancreas PANC-1). Intriguingly, compound 4 exhibited anti-austerity activity with an IC50 of 22.43 μM against PANC-1 cancer cells under glucose starvation conditions, while compound 2 did not.

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Section: Antiproliferative Activity Of Isolated Compounds Against Thr...mentioning

confidence: 99%

Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii

Sirimangkalakitti,

Lin,

Harada

et al. 2024

Molecules

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“…The production of metabolites from Aspergillus fumigatus may be regulated by specific ecological factors, such as the microbial rivals, and symbionts [3] . The co‐culture and host medium were proven to be an effective strategy to produce rare metabolites from fungi [4–7] . The metabolites from cocultures of P. chrysogenum ‐ N. primolutea and P. chrysogenum ‐ A. fumigatus isolated from plant Ziziphus jujuba by supplementing with host Z. jujuba extract showed differences by comparing with those of monocultures.…”

Section: Introductionmentioning

confidence: 99%

Novel Antifungal and Antifeedant Metabolites from Penicillium chrysogenum Co‐Cultured with Nemania primolutea and Aspergillus fumigatus

Yang

Cen

et al. 2023

Chemistry & Biodiversity

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The endophyte Nemania primolutea, inhibited the growth of Penicillium chrysogenum in the coculture system. Four new compounds, nemmolutines A -B (1 -2), and penigenumin (3) from N. primolutea, penemin (4) from P. chrysogenum were isolated from the coculture. On the other hand, P. chrysogenum inhibited the Aspergillus fumigatus in the coculture. Induced metabolites (13-16) with monasone naphthoquinone scaffolds including a new one from P. chrysogenum were produced by the coculture of P. chrysogenum, and A. fumigatus. Interesting, cryptic metabolites penicichrins A -B isolated from wild P. chrysogenum induced by host Ziziphus jujuba medium were also found in induced P. chrysogenum cultured in PDB ordinary medium. So the induction of penicichrin production by supplementing with host extract occurred in the fungus P. chrysogenum not the host medium. The productions of penicichrins were the spontaneous metabolism, and the metabolites (13 -16) were the culture driven. Compounds 4, 6, 8, 10, 11, 14, and 15 showed significant antifungal activities against the phytopathogen Alternaria alternata with MIC S of 1 -8 μg/mL, and compounds 7, 9, and 12 indicated significant antifeedant activities against silkworms with feeding deterrence indexes (FDIs) of 92 %, 66 %, and 64 %. The carboxy group in 4-(2-hydroxybutynoxy)benzoic acid derivatives, and xylabisboeins; the hydroxy group in mellein derivatives; and the quinoid in monasone naphthoquinone increased the antifungal activities.

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The Application of Carbon-Based Fertilizer Changed the Microbial Composition and Co-Occurrence Network Topological Properties of Vineyard Soil

Sun,

Wu,

Lin

et al. 2024

Horticulturae

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Charcoal-based fertilizer could be used extensively and is environmentally friendly. An experiment was designed to investigate the effects of different charcoal-based fertilizer application methods on soil microbiology and grape quality in a vineyard to guide the cultivation of ‘Shine-Muscat’. A control treatment without fertilization and six other treatments were set up. Four treatments applied carbon-based fertilizer as a base fertilizer with or without potassium fulvic acid, a complex microbial agent, or Bacillus subtilis, and two treatments were only applied with two applications of carbon-based fertilizer or compound fertilizer during the expansion period. The results showed that the bacterial phyla were mainly Proteobacteria and Bacteroidetes. Ascomycota, Basidiomycota, and Mortierellomycota dominated the fungal community. At the genus level, the composition of fungi, compared to bacteria, varied significantly, while the dominant flora differed among fertilization practices. Application of charcoal-based fertilizer enriched beneficial microorganisms, while chemical fertilizers enriched pathogenic microorganisms. The addition of microbial fungicides and biostimulants for a period reduced the size of the microbial network, lowered positive correlations, and enhanced resistance to adverse conditions and diseases and there was no significant correlation between agronomic traits and microbial network topology. A combination of soil microbial and grape agronomic traits suggests that a charcoal-based fertilizer base, with microbial fungicides applied, is the optimal fertilization regimen for grape.

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Three New Azaphilone Phytotoxins from Coculture of the Phytopathogens Nigrospora oryzae and Colletotrichum gloeosporioides and Antifungal Activities Against N. oryzae

Cited by 3 publications

References 13 publications

Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii

Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii

Novel Antifungal and Antifeedant Metabolites from Penicillium chrysogenum Co‐Cultured with Nemania primolutea and Aspergillus fumigatus

The Application of Carbon-Based Fertilizer Changed the Microbial Composition and Co-Occurrence Network Topological Properties of Vineyard Soil

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