Three new C20-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri

Liu, Xiao Yu; Chen, Qiao Hong; Wang, Feng Peng

doi:10.1016/j.cclet.2008.12.056

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…As far as we know, there were only six denudatine-type C 20 -diterpenoid alkaloids that contain 16, 17-epoxy group reported before (Bando et al 1987;Sakai et al 1987;Liu et al 2009;Zhang et al 2010). Compound 1 was the first C 20 -diterpenoid with a denudatine skeleton bearing a 16, 17-epoxy group and a C-1-C-19 carbinolamine inner ether isolated from a natural source, providing a new candidate for further pharmacological investigation.…”

Section: Resultsmentioning

confidence: 90%

A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Chen

Shan

et al. 2016

Natural Product Research

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A new denudatine-type C-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.

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Section: Resultsmentioning

confidence: 90%

A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Chen

Shan

et al. 2016

Natural Product Research

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“…Anthriscifolium of the genus Delphinium, the chemical constituents of D. anthriscifolium var. savatieri had been studied systematically by our group in recent years, which resulted in the isolation of seven C 18 -, nine C 19 -, and ten C 20 -diterpenoid alkaloids [6][7][8][9]. The present investigation on a re-collection of this plant led to the isolation of another two new C 20 -diterpenoid alkaloids, designated as anthriscifolmines I (1) and J (2).…”

mentioning

confidence: 74%

Two New C₂₀-Diterpenoid Alkaloids from Delphinium anthriscifolium var. savatieri

Liu

Song

Chen

et al. 2010

Natural Product Communications

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“…Most of the denudatine DAs (compounds 81–89 in Figure 14 ) originate from Aconitum spp , except DAs 123–124 obtained from the whole herb of Delphinium anthriscifolium var. savatieri [ 81 ]. A hydroxyl group and an oxygenated group are respectively on C16 and C17 in DAs 117–120 .…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera. Corals, Xenia, Okinawan/Clavularia, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances. Compounds belonging to this unique and fascinating family of natural products exhibit a broad spectrum of biological activities. Some of these compounds are on the list of clinical drugs, while others act as incredibly potent neurotoxins. Despite numerous attempts to prepare synthetic products, this review only introduces the natural diterpenoid alkaloids, describing ‘compounds’ structures and classifications and their toxicity and bioactivity. The purpose of the review is to highlight some existing relationships between the presence of substituents in the structure of such molecules and their recognised bioactivity.

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Three new C20-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri

Cited by 12 publications

References 5 publications

A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Two New C₂₀-Diterpenoid Alkaloids from Delphinium anthriscifolium var. savatieri

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

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Three new C20-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri

Cited by 12 publications

References 5 publications

A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

A new C20-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Two New C20-Diterpenoid Alkaloids from Delphinium anthriscifolium var. savatieri

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

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A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Two New C₂₀-Diterpenoid Alkaloids from Delphinium anthriscifolium var. savatieri