Three new compounds from the roots of <i>Saposhnikovia divaricata</i>

Kang, Jie; Zhou, Lei; Sun, Jun; Ye, Min; Han, Jian; Wang, Baorong; Guo, Dan

doi:10.1080/10286020802217556

Cited by 20 publications

(7 citation statements)

References 5 publications

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“…Cells (10 4 A c c e p t e d M a n u s c r i p t 14 compound 1, was elucidated by comparing the data of (-13.2) with that of compound 2 (-23.0) reported [8,9]. Then, the absolute configuration of C-12 was determined as S-configuration.…”

Section: Nad(p)h: Quinine Oxidoreductase 1 Inducing Activities Assaymentioning

confidence: 99%

Biotransformation of Licochalcone A by transgenic crown galls of Panax quinquefolium

Huang

et al. 2014

Journal of Molecular Catalysis B: Enzymatic

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Section: Nad(p)h: Quinine Oxidoreductase 1 Inducing Activities Assaymentioning

confidence: 99%

Biotransformation of Licochalcone A by transgenic crown galls of Panax quinquefolium

Huang

et al. 2014

Journal of Molecular Catalysis B: Enzymatic

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“…SR is one of the most significant traditional Chinese medicines (TCMs). It has been widely used for the treatment of pyrexia, rheumatism, headache and convulsion for thousands of years in Chinese clinical practices (Xiao et al 2002;Wang et al Wang and Lou 1992;Kang et al 2008). For GR, it is one of the Chinese medicines used as a tonic, antiphlogistic and mucolytic herb for treatment of respiratory and gastrointestinal disorders, while it is used in Japan as a diaphoretic, antipyretic, and analgesic medicine (Sasaki et al 1980).…”

Section: Introductionmentioning

confidence: 98%

Simultaneous analysis of seven marker compounds from Saposhnikoviae Radix, Glehniae Radix and Peucedani Japonici Radix by HPLC/PDA

et al. 2016

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A new combination of high performance liquid chromatography (HPLC) method coupled with photodiode array (PDA) analysis has been developed for the simultaneous quantitative determination of seven major components in Saposhnikoviae Radix (SR), Glehniae Radix (GR) and Peucedani Japonici Radix (PR), namely peucedanol 7-O-β-D-glucopyranoside (1), prim-O-glucosylcimifugin (2), cimifugin (3), 4'-O-β-D-glucosyl-5-O-methylvisamminol (4), bergapten (5), sec-O-glucosylhamaudol (6), and imperatorin (7). Clear separation of these seven components were achieved on a Phenomenex Kinetex C18 (250 × 4.6 mm, 5 μm) column by gradient elution of water (A) and methanol (B) as mobile phase. The flow rate was 1.0 mL/min and the UV detector wavelength was set at 254 nm. The method was successfully used in the analysis of SR, GR, and PR with relatively simple conditions and procedures, and the results were satisfactory for linearity, recovery, precision, accuracy, stability and robustness. The results indicate that the established HPLC/PDA method is suitable for the classification of SR, GR, and PR.

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“…schischk in family Umbelliferae, and is commonly used for treating febrility, rheumatism, headache, vertigo, generalized aching, convulsion, arthralgia and inflammatory symptoms for thousands of years in China, Japan, and Korea12345. Modern scientific experiments have also confirmed the beneficial effects of RS using its extracts1567.…”

mentioning

confidence: 99%

“…1). In Chinese pharmacopoeia, PGCN and GML are designated as marker compounds for RS quality control due to their relatively high content and GML is also used for the identification of RS in Japanese Pharmacopoeia341011. Cimifugin is aglycone of PGCN and has much lower content than that of PGCN and GML.…”

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Polysaccharide enhances Radix Saposhnikoviae efficacy through inhibiting chromones decomposition in intestinal tract

Yang

Jiang

Dai

et al. 2016

Sci Rep

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Vegetative but not reproductive stage of Saposhnikovia divaricate (Turxz.) schischk possesses pharmacological activities. However, our recent study showed that reproductive S. divaricate supplemented with polysaccharide showed evidently elevated pharmacological activities and increased cimifugin content in rat serum. The aims of present study were to assess the influence of polysaccharides on the chromones pharmacological activities in Radix Saposhnikoviae (RS), the dried root of vegetative stage of S. divaricate, and to explore the underlying mechanisms. Only cimifugin was detected in the plasma of chromone treated animals and RS polysaccharide significantly increased the plasma content of cimifugin. It was shown that neither cimifugin absorption nor glycoside components transformation in simulated digestive fluid was affected by RS polysaccharide. However, a significant promotion of transformation of cimifugin to more stable prime-O-glucosylcimifugin (PGCN) by RS polysaccharide, and a protective effect of polysaccharide on chromone components were observed in small intestine solutions. Meanwhile, RS polysaccharide produced a significant elevation of cimifugin and PGCN concentration in vivo. Based on these findings, we concluded that RS polysaccharide could greatly increase the content of cimifugin, which might be related to its degradation-proof effect on cimifugin, via transforming cimifugin to comparatively more stable PGCN and spatial structure protection.Radix Saposhnikoviae (RS) is the dried root of vegetative stage of perennial herb Saposhnikovia divaricate (Turxz.) schischk in family Umbelliferae, and is commonly used for treating febrility, rheumatism, headache, vertigo, generalized aching, convulsion, arthralgia and inflammatory symptoms for thousands of years in China, Japan, and Korea 1-5 . Modern scientific experiments have also confirmed the beneficial effects of RS using its extracts 1,5-7 . RS contains various bioactive substances, such as chromones, coumarins, polyacetylenes, and polysaccharides. Among them, chromones and coumarins are the main components of RS 4,8,9 . Furthermore, chromones have also been identified as the main bioactive constituents with most-evident pharmacological activities as they possess potent analgesic, antifebric, anti-inflammatory and immune-regulatory effects 1,5 .Currently, three major types of chromones were found in RS, including prime-O-glucosylcimifugin (PGCN), 4′ -O-β -D-glucosyl-5-O-methylvisamminol (GML), and cimifugin (Fig. 1). In Chinese pharmacopoeia, PGCN and GML are designated as marker compounds for RS quality control due to their relatively high content and GML is also used for the identification of RS in Japanese Pharmacopoeia 3,4,10,11 . Cimifugin is aglycone of PGCN and has much lower content than that of PGCN and GML. Huge amount of cimifugin and trace amount of PGCN and GML were detected in the plasma sample of overdose chromone 4,12 . Generally, cimifugin is regarded as the pharmacologically active form of inactive chromone derivatives such as P...

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Three new compounds from the roots of Saposhnikovia divaricata

Cited by 20 publications

References 5 publications

Biotransformation of Licochalcone A by transgenic crown galls of Panax quinquefolium

Biotransformation of Licochalcone A by transgenic crown galls of Panax quinquefolium

Simultaneous analysis of seven marker compounds from Saposhnikoviae Radix, Glehniae Radix and Peucedani Japonici Radix by HPLC/PDA

Polysaccharide enhances Radix Saposhnikoviae efficacy through inhibiting chromones decomposition in intestinal tract

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