Three new genes associated with longevity in the European Bison

Korec, E; Ungrová, Lenka; Hejnar, Jiřı́; Grieblová, Adéla; Zelená, Kateřina

doi:10.1016/j.vas.2022.100266

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…On the other hand, when analyzing the LZG breed, the Q-Q plot and lambda value indicated a weak association and raised concerns about potential population stratification. This finding mirrors observations from previous whole-genome population studies of animals [64]. One critical aspect that emerged from the quality measures was the relatively low number of animals included in the association analysis.…”

Section: Mastitis Resistancesupporting

confidence: 84%

“…This limitation might have influenced the statistical power and precision of our findings. However, it is worth noting that similar studies with a comparable number of animals have previously been conducted [63][64][65][66][67][68]. Despite this constraint, the results and knowledge obtained offer valuable insights and could serve as a foundation for future investigations related to Latvian local cattle breeds.…”

Section: Mastitis Resistancementioning

confidence: 87%

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Genomic Characterization and Initial Insight into Mastitis-Associated SNP Profiles of Local Latvian Bos taurus Breeds

Gudra,

Valdovska,

Jonkus

et al. 2023

Animals

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Latvia has two local Bos taurus breeds—Latvian Brown (LBG) and Latvian Blue (LZG)—characterized by a good adaptation to the local climate, longevity, and high fat and protein contents in milk. Since these are desired traits in the dairy industry, this study investigated the genetic background of the LBG and LZG breeds and identified the genetic factors associated with mastitis. Blood and semen samples were acquired, and whole genome sequencing was then performed to acquire a genomic sequence with at least 35× or 10× coverage. The heterozygosity, nucleotide diversity, and LD analysis indicated that LBG and LZG cows have similar levels of genetic diversity compared to those of other breeds. An analysis of the population structure revealed that each breed clustered together, but the overall differentiation between the breeds was small. The highest genetic variance was observed in the LZG breed compared with the LBG breed. Our results show that SNP rs721295390 is associated with mastitis in the LBG breed, and SNPs rs383806754, chr29:43998719CG>C, and rs462030680 are associated with mastitis in the LZG breed. This study shows that local Latvian LBG and LZG breeds have a pronounced genetic differentiation, with each one suggesting its own mastitis-associated SNP profile.

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Section: Mastitis Resistancesupporting

confidence: 84%