Three New Lactone-Type Diterpenoid Alkaloids from Aconitum rotundifolium Kar. &amp; Kir.

Zhou, Xian‐Li; Frejat, Firas Obaid Arhema; Xu, Wenliang; Shan, Lianhai

doi:10.3987/com-17-13768

Cited by 10 publications

(4 citation statements)

References 9 publications

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“…Rotundifolia. 88,89 The component distribution was consistent with the degree of plant evolution within this phytogroup, which demonstrated the chemotaxonomic values of C 18 -DAs as chemotaxonomic markers.…”

Section: Chemotaxonomysupporting

confidence: 66%

C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

Yan

Wang

et al. 2022

RSC Adv.

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Section: Chemotaxonomysupporting

confidence: 66%

C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

Yan

Wang

et al. 2022

RSC Adv.

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“…A six-membered lactone characterises this class (structures 82–85 in Figure 7 ) obtained by the oxidation of the ketone existing at C14 of aconitine ( Figure 7 ) [ 65 , 66 , 67 ].…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

“…They also have an oxygenated functionality at the C6 position in most cases. Only a very few alkaloids have no oxygenated groups at both C6 and C16 positions [ 65 , 66 , 67 ].…”

Section: Classification Of Diterpenoid Alkaloidsmentioning

confidence: 99%

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Thawabteh

Lelario

et al. 2021

Molecules

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Diterpenoid alkaloids are natural compounds having complex structural features with many stereo-centres originating from the amination of natural tetracyclic diterpenes and produced primarily from plants in the Aconitum, Delphinium, Consolida genera. Corals, Xenia, Okinawan/Clavularia, Alcyonacea (soft corals) and marine sponges are rich sources of diterpenoids, despite the difficulty to access them and the lack of availability. Researchers have long been concerned with the potential beneficial or harmful effects of diterpenoid alkaloids due to their structural complexity, which accounts for their use as pharmaceuticals as well as their lousy reputation as toxic substances. Compounds belonging to this unique and fascinating family of natural products exhibit a broad spectrum of biological activities. Some of these compounds are on the list of clinical drugs, while others act as incredibly potent neurotoxins. Despite numerous attempts to prepare synthetic products, this review only introduces the natural diterpenoid alkaloids, describing ‘compounds’ structures and classifications and their toxicity and bioactivity. The purpose of the review is to highlight some existing relationships between the presence of substituents in the structure of such molecules and their recognised bioactivity.

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“…11 Studies on diterpenoid alkaloids in Aconitum plants could contribute to the development of new natural medicines. [12][13][14] Aconitum elliotii Lauener, a herbaceous plant belonging to the family Ranunculaceae, is a species endemic to Motuo and Milin in eastern Tibet. At present, there is no relevant report on the chemical composition of A. elliotii Lauener.…”

Section: Introductionmentioning

confidence: 99%

Diterpenoid Alkaloids from Aconitum elliotii Lauener

Zhou¹,

Huang²,

Zhang³

et al. 2023

HETEROCYCLES

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Three new diterpenoid alkaloids (1-3), which were named elliotitine A(1), 8-O-ethylindaconitine (2) and 8-O-ethylbikhaconine (3), along with thirty-three known compounds, were isolated from the roots of Aconitum elliotii Lauener. Their structures were elucidated via HR-ESI-MS, 1D and 2D NMR, and X-ray data.Additionally, the anti-inflammation activities of all compounds were evaluated, no compound showed significant anti-inflammatory activity.

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Three New Lactone-Type Diterpenoid Alkaloids from Aconitum rotundifolium Kar. & Kir.

Cited by 10 publications

References 9 publications

C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Diterpenoid Alkaloids from Aconitum elliotii Lauener

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Three New Lactone-Type Diterpenoid Alkaloids from Aconitum rotundifolium Kar. & Kir.

Cited by 10 publications

References 9 publications

C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

Diterpenoid Alkaloids from Aconitum elliotii Lauener

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C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

C₁₈-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities