Three new lignans from the nutmeg of Myristica cagayanesis.

Kuo, Yueh‐Hsiung; Lin, Shi-Chun; Wu, Rong-En

doi:10.1248/cpb.37.2310

Cited by 28 publications

(6 citation statements)

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“…Based on the comparison of the spectroscopic data with those reported, compounds 1-9 were identified as four known lignans: epischisandrone (1) (Liu et al, 1988b), tigloylgomisin P (2) (Ikeya et al, 1980), cagayanone (3) (Kuo et al, 1989) and (À)-gomisin L 2 (4) (Ikeya et al, 1982), as well as Figure 1. Structures of compounds 1-9.…”

Section: Resultsmentioning

confidence: 95%

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Liu

et al. 2013

Pharmaceutical Biology

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Context: The diethyl ether extract of the stems of Schisandra pubescens Hemsl. et Wils. (Schisandraceae) was found to exhibit cytotoxic activity in vitro. However, investigations of the bioactive constituents of this plant have been very limited. Objective: Elucidation of the cytotoxic constituents of S. pubescens was performed. Methods: Repeated silica gel column chromatography and preparative TLC were used for the chemical investigation of the diethyl ether extract of S. pubescens stems. All isolates were evaluated for their in vitro cytotoxicity against A549, PC-3, KB and KBvin human cancer cell lines. Results: Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (À)-gomisin L 2 (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9). Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI 50 values of 11.83-35.65 mM. Conclusion: The isolation of 1-9 from S. pubescens and the cytotoxicities of 3-6 are first reported. Compounds 2-6 and 8 could be the active principles responsible for the anticancer effects of S. pubescens.

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Section: Resultsmentioning

confidence: 95%

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Liu

et al. 2013

Pharmaceutical Biology

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“…1) together with the known compounds (À)-futokadsurin C (3) and (À)-8 0 -epi-aristoligone (4a). They were analyzed by spectroscopic methods, and the known compounds were identified by comparison with data reported in the literature (da Silva and Lopes, , 2006Konishi et al, 2005;Kuo et al, 1989) (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Pereira

Ferreira

Messiano

et al. 2015

Phytochemistry Letters

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Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (À)-8 0-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL 50) evaluated. (À)-Cyclogalgravin and (À)-aristoligol exhibited activity (IC 50 $ 10.8 and 8.4 mM, respectively), the latter exhibited lower toxicity.

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“…The three compounds were identified as malabaricones A, B and C. The resorcinols have been detected in M. malabarica (Sen et al, 2007), Myristica cagayanesis (Kuo et al, 1989), Myristica gigantean (Pharm et al, 2002), Myristica maingayi (Pharm et al, 2000) and Myristica fragrans (Orabi et al, 1991). As for the biological activities of malabaricones, they have been reported to have antioxidant (Patro et al, 2005), arg-gingipain inhibitory (Shinohara et al, 1999), antimicrobial (Orabi et al, 1991;Shinohara et al, 1999) and antipromastigote (Sen et al, 2007) activities.…”

Section: Discussionmentioning

confidence: 99%

Nematicidal activity of malabaricones isolated from Myristica malabarica fruit rinds against Bursaphelenchus xylophilus

Choi

Kwon

Son

et al. 2008

Nematol

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Plant extracts from 50 plant species were tested for their nematicidal activities against Bursaphelenchus xylophilus, the causative agent of pine wilt disease. Out of 50 extracts, the methanol extract of Myristica malabarica fruit rinds showed the most potent nematicidal activity with mortality of 100% at a concentration of 1000 μg ml −1 against B. xylophilus. Three nematicidal substances were isolated by bioassay-guided fractionation and then identified as malabaricones A, B and C by mass and NMR spectral data. Both malabaricones B and C showed higher activity than malabaricone A. There was a significant synergistic interaction between the three compounds on the pine wood nematode. When the combination of three compounds at a ratio of 1 : 1 : 1 was applied, its EC 50 value was 11.8 μg ml −1 . These results indicate that the extract of M. malabarica containing the three resorcinols could be useful as a natural nematicide for the control of pine wilt disease.

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Three new lignans from the nutmeg of Myristica cagayanesis.

Cited by 28 publications

References 0 publications

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Cytotoxic and potential anticancer constituents from the stems ofSchisandra pubescens

Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Nematicidal activity of malabaricones isolated from Myristica malabarica fruit rinds against Bursaphelenchus xylophilus

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