2021
DOI: 10.1177/1934578x211055009
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Three New Metabolites From the Marine-Derived Fungus Aspergillus sp. WHUF03110

Abstract: Two new xanthone derivatives, spinosusones A (1) and B (2), and a new tryptoquivaline analogue, asperdiazapinone G (3), together with nine known compounds (4-12) were isolated from the EtOAc extract of the marine-derived fungus Aspergillus sp . WHUF03110. The structures of 1-3 were determined by spectroscopic analysis, and comparison with literature data. Most of these isolated compounds were evaluated for their antimicrobial activities against ten Gram-negative and seven Gram-positive bacteria, Mycobacterium … Show more

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Cited by 8 publications
(11 citation statements)
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“…Then, the cultured broth is filtered and extracted, most often, with EtOAc. This extract is subjected to a vacuum liquid chromatography over a silica gel column [ 15 , 16 , 21 , 23 ], flash chromatography [ 19 ] or, most commonly, to normal column chromatography (CC) [ 14 , 17 , 18 , 20 , 22 ], originating different fractions, which can be subjected to analysis by HPLC or TLC, obtaining sub-fractions, or be directly purified to obtain pure compounds. Most of the xanthones herein referred to were obtained after semi-preparative HPLC purifications of these sub-fractions.…”
Section: New Marine Xanthones Isolated Since 2010mentioning
confidence: 99%
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“…Then, the cultured broth is filtered and extracted, most often, with EtOAc. This extract is subjected to a vacuum liquid chromatography over a silica gel column [ 15 , 16 , 21 , 23 ], flash chromatography [ 19 ] or, most commonly, to normal column chromatography (CC) [ 14 , 17 , 18 , 20 , 22 ], originating different fractions, which can be subjected to analysis by HPLC or TLC, obtaining sub-fractions, or be directly purified to obtain pure compounds. Most of the xanthones herein referred to were obtained after semi-preparative HPLC purifications of these sub-fractions.…”
Section: New Marine Xanthones Isolated Since 2010mentioning
confidence: 99%
“…Naturally, the eluents and gradients used differ depending on the extracts/fractions being analyzed. The most common eluents used are organic solvents mixtures, such as n -hexane/CH 2 Cl 2 /MeOH [ 16 ], n -hexane/EtOAc [ 15 ], CH 2 Cl 2 /MeOH [ 15 , 18 , 20 , 21 , 23 ], gradient of petroleum ether/EtOAc [ 14 , 17 , 18 ], but mixtures of H 2 O/MeOH can also be used successfully [ 19 ].…”
Section: New Marine Xanthones Isolated Since 2010mentioning
confidence: 99%
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