Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii

Yang, Haiying; Duan, Yan-Qing; Yang, Ye‐Kun; Li, Jing; Liu, Xin; Ye, Lin; Mi, Qi-Li; Kong, Wei-Song; Zhou, Min; Yang, Guangyu; Li, Xuemei; Hu, Qiu‐Fen

doi:10.1016/j.phytol.2017.10.021

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…yunnanensis was the source of three new compounds namely 3-hydroxy-1-(1,8dihydroxy-3,6-dimethoxynaphthalen-2-yl)propan-1-one (6), 3-hydroxy-1-(1,3,8-trihydroxy-6-methoxynaphthalen-2-yl)propan-1-one (7) and 3-hydroxy-1-(1,8-dihydroxy3,5-dimethoxy naphthalen-2-yl) propan-1-one (8, Figure 1). Compounds 6-8 exhibited anti-MRSA-ZR11 activity, with MIC values of 8, 4, and 4 µg/mL, respectively [21]. Later two new di-Ph ethers, 1-[2-methoxy-4-(3-methoxy-5-methylphenoxy)-6-methylphenyl]-ethanone (9) and 1-[4-(3-(hydroxymethyl)-5-methoxyphenoxy)-2-methoxy-6-methylphenyl]-ethanone (10, Figure 1), were also purified from the same fungus.…”

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

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Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

“…lachrymans with MIC values of 15.6 µg/mL, and compounds (−)-1 (20 and 21) displayed poor activity with MICs of 31.2 µg/mL each. Compounds (−)-1, (+)-1, (20,21,22) showed antibacterial activity against Xanthomonas citri pv. phaseoli var.…”

Section: Diaporthe (Asexual State: Phomopsis)mentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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“…yunnanensis . Compounds 128 – 130 showed anti-MRSA activities with MCI values of 4, 4 and 6 mg/mL [ 68 ]. From fermentation products of the fungus Phomopsis sp.…”

Section: Bioactive Secondary Metabolites From Phomopsis mentioning

confidence: 99%

Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019

Wang

et al. 2021

Microorganisms

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The genus Diaporthe and its anamorph Phomopsis are distributed worldwide in many ecosystems. They are regarded as potential sources for producing diverse bioactive metabolites. Most species are attributed to plant pathogens, non-pathogenic endophytes, or saprobes in terrestrial host plants. They colonize in the early parasitic tissue of plants, provide a variety of nutrients in the cycle of parasitism and saprophytism, and participate in the basic metabolic process of plants. In the past ten years, many studies have been focused on the discovery of new species and biological secondary metabolites from this genus. In this review, we summarize a total of 335 bioactive secondary metabolites isolated from 26 known species and various unidentified species of Diaporthe and Phomopsis during 2010–2019. Overall, there are 106 bioactive compounds derived from Diaporthe and 246 from Phomopsis, while 17 compounds are found in both of them. They are classified into polyketides, terpenoids, steroids, macrolides, ten-membered lactones, alkaloids, flavonoids, and fatty acids. Polyketides constitute the main chemical population, accounting for 64%. Meanwhile, their bioactivities mainly involve cytotoxic, antifungal, antibacterial, antiviral, antioxidant, anti-inflammatory, anti-algae, phytotoxic, and enzyme inhibitory activities. Diaporthe and Phomopsis exhibit their potent talents in the discovery of small molecules for drug candidates.

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