Three new platinum(II)—dipeptide complexes

Shi, Dashuang; Hambley, Trevor W.; Freeman, H.C.

doi:10.1016/s0162-0134(99)00015-x

Cited by 22 publications

(15 citation statements)

References 76 publications

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“…[31,32] Furthermore, K[PtCl 3 (dmso)] successfully provided a chelate complex with Gly-His where reaction of this ligand with K 2 PtCl 4 failed. [33] In the event, when a slight molar excess of Amgu·HCl was added to a solution of K[PtCl 3 (dmso)] in water, a solid product began forming after only 90 min. A satisfactory 73 % yield of a single chelate complex was obtained; its composition was suggested as [PtCl(Amgu)(dmso)]Cl (5) from analytical and spectro- scopic data (in particular 1 H NMR signal integrations and a single 195 Pt NMR signal at δ = -3134 ppm) and was confirmed by X-ray diffraction ( Figure 5).…”

Section: Platinum Complexesmentioning

confidence: 99%

Platinum(II) and Palladium(II) Complexes with N‐Aminoguanidine

et al. 2007

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N-Aminoguanidine (Amgu) was examined for its behaviour as a ligand for platinum(II) and palladium(II). Protonated AmguH + can coordinate platinum as a monodentate ligand bound via the N4 amino group. Deprotonated, electrically neutral Amgu forms chelate complexes with both Pt II and Pd II ; in these complexes Amgu is coordinated to the metal by the N4 amino group and the deprotonated N1 imino group, forming a five-membered ring. K[PtCl 3 (dmso)] reacted with Amgu·HCl to yield a chelate complex with N1 bound trans to S, suggesting that an exchange between the N1 and N4 binding sites followed the primary nucleophilic attack of N4

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Section: Platinum Complexesmentioning

confidence: 99%

Platinum(II) and Palladium(II) Complexes with N‐Aminoguanidine

et al. 2007

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“…Spectra of H-Phe-Tyr-OH and H-Tyr-Phe-OH showed peaks at 3290-3180 cm À1 ( OH(solvent) , NH , OH(Tyr) ), at 3080-3050 cm À1 ( as NH3þ ) [170][171][172][173], and at 1700 cm À1 ( C¼O(COOH) ) in the protonated forms. The bands within the 1800-1500 cm À1 region are assigned as follows: H-Tyr-Phe-OH: 1675 cm À1 ( C¼O ), 1613 cm À1 (8a, i.p.…”

Section: Introductionmentioning

confidence: 99%

“…PLUTON diagram of the Pt II complex of H-Met-Gly-OH[172] (1), bis(glycinato)Cu II complex (2) and (glycyltryptophane)Cu II (3)[216].…”

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confidence: 99%

Protonation and coordination ability of small peptides – theoretical and experimental approaches for elucidation

Lamshöft

Ivanova

2011

Journal of Coordination Chemistry

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This review deals with modern theoretical and experimental approaches as well as structural elucidation of small peptides (SP), their protonated forms and metal complexes. Free peptide bond rotation in amino acids (AA) and peptides yielded various conformers, which may possess differing biological activities. Inter-and/or intramolecular stacking observed in aromatic SP is another phenomenon typical for both peptide salts and complexes. These phenomenological effects can be successfully studied, both theoretically and experimentally, using a combination of the theoretical approximations and physical methods, such as electronic absorption spectroscopy, vibrational spectroscopy (including IR and Raman), nuclear magnetic resonance, mass spectrometry, as well as single-crystal X-ray diffraction. The physical and chemical properties of these systems can be precisely calculated by ab initio and DFT methods, varying basis sets and the results obtained allow elucidation of their conformations as a function of the reaction conditions (pH, type of the solvent, temperature, metal to ligand molar ratio). Although the 3-D structures of many peptides have been determined over the past decades, peptide crystallization is still a major obstacle to crystallographic work and the presence of chiral center/s adds further difficulties. For this reason, a specific part of the review is focused on the study of the absolute structure of the peptides, their salts and metal complexes, discussing the conformational preferences of the peptides during these processes. The available crystallographic data for metal complexes are successfully used for the correlation between the structures and the spectroscopic properties.

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“…Complex 1 was prepared by a similar method previously reported [11]. To an aqueous solution (10 ml) of K 2 [PtC1 4 ] (200 mg, 0.482 mmol) a solution (10 ml) of the L-methionylglycine (100 mg, 0.428 mmol) was added.…”

Section: Synthesismentioning

confidence: 99%

“…1) comprised of L-methionine, which form six-membered chelating rings. Freeman et al [11] reported the crystal structure of the [PtCl 2 (L-metgly)] complex. We also report similar types of platinum(II) complexes containing halide ligands (chloro or iodo) and Lleucine as second amino acid in dipeptide.…”

Section: Introductionmentioning

confidence: 99%