Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Lafont, Anne Gaëlle; Rousseau, Karine; Tomkiewicz, Jonna; Dufour, Sylvie

doi:10.1016/j.ygcen.2015.11.021

Cited by 35 publications

(48 citation statements)

References 97 publications

(121 reference statements)

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“…In the female European eel, only ESR1 levels increased in the forebrain with maturation, with ESR2a and ESR2b levels remaining stable (Lafont et al, 2015). These results again suggest a differential regulation of the nuclear estrogen receptors during the maturation of male and female eels.…”

Section: Brain and Pituitary Estrogen Receptor Expression Levels Durimentioning

confidence: 62%

“…The quantitative real-time Polymerase Chain Reactions (qPCR) were carried out using specific qPCR primers for each European eel estrogen nuclear and membrane receptor (Lafont et al, 2015) and the Acidic ribosomal phosphoprotein P0 (ARP) (Weltzien et al, 2005) was used as the reference gene (Table 1).…”

Section: Gene Expression Analyses By Quantitative Real-time Pcrmentioning

confidence: 99%

“…According to Lafont et al (2015), ESR1 expression levels in the pituitary of female European eels increased as the eels matured, showing a difference in the expression of ESR1 between the sexes. ESR2a and ESR2b expression levels remained unchanged in both sexes (Lafont et al, 2015;this study).…”

Section: Brain and Pituitary Estrogen Receptor Expression Levels Durimentioning

confidence: 99%

“…They belong to the nuclear steroid receptor superfamily, as well as androgen, progestin, gluco-and mineralocorticoid receptors (Carson-Jurica et al, 1990;Laudet et al, 1992). Teleost species have at least three distinct ESR subtypes, including ESR1, ESR2a and ESR2b (Hawkins et al, 2000;Ma et al, 2000;Menuet et al, 2002), with ESR2a (also named ERβ2) and ESR2b (also named ERβ1) resulting from the third whole genome duplication (3R) event that occurred in teleost lineage (Hawkins et al, 2000;Lafont et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In mammals, the former orphan receptor GPR30 was characterized as an E 2 membrane receptor, and is also called G-protein coupled estrogen receptor GPER (Filardo and Thomas, 2005;Filardo et al, 2007; for review see Prossnitz and Maggiolini, 2009). Two membrane GPERs have recently been observed in most teleosts including the eel, likely resulting from teleost 3R (Lafont et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

Morini

Peñaranda

Vílchez

et al. 2017

Comparative Biochemistry and Physiology Part A: Molecular &

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Estradiol (E) can bind to nuclear estrogen receptors (ESR) or membrane estrogen receptors (GPER). While mammals possess two nuclear ESRs and one membrane GPER, the European eel, like most other teleosts, has three nuclear ESRs and two membrane GPERs, as the result of a teleost specific genome duplication. In the current study, the expression of the three nuclear ESRs (ESR1, ESR2a and ESR2b) and the two membrane GPERs (GPERa and GPERb) in the brain-pituitary-gonad (BPG) axis of the European eel was measured, throughout spermatogenesis. The eels were first transferred from freshwater (FW) to seawater (SW), inducing parallel increases in E plasma levels and the expression of ESRs. This indicates that salinity has a stimulatory effect on the E signalling pathway along the BPG axis. Stimulation of sexual maturation by weekly injections of human chorionic gonadotropin (hCG) induced a progressive decrease in E plasma levels, and different patterns of expression of ESRs and GPERs in the BPG axis. The expression of nuclear ESRs increased in some parts of the brain, suggesting a possible upregulation due to a local production of E. In the testis, the highest expression levels of the nuclear ESRs were observed at the beginning of spermatogenesis, possibly mediating the role of E as spermatogonia renewal factor, followed by a sharply decrease in the expression of ESRs. Conversely, there was a marked increase observed in the expression of both membrane GPERs throughout spermatogenesis, suggesting they play a major role in the final stages of spermatogenesis.

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Section: Brain and Pituitary Estrogen Receptor Expression Levels Durimentioning

confidence: 62%

Section: Gene Expression Analyses By Quantitative Real-time Pcrmentioning

confidence: 99%

Section: Brain and Pituitary Estrogen Receptor Expression Levels Durimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

Morini

Peñaranda

Vílchez

et al. 2017

Comparative Biochemistry and Physiology Part A: Molecular &

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Characterization of G protein‐coupled estrogen receptors in Japanese medaka, Oryzias latipes

Miyaoku

Ogino

Lange

et al. 2020

J of Applied Toxicology

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The G protein‐coupled estrogen receptor 1 (Gper1) is a membrane‐bound estrogen receptor that mediates non‐genomic action of estrogens. A Gper1‐mediating pathway has been implicated in reproductive activities in fish, including oocyte growth, but Gper1 has been characterized in only a very limited number of fish species. In this study, we cloned and characterized two genes encoding medaka (Oryzias latipes) Gper1s, namely, Gper1a and Gper1b, and phylogenic and synteny analyses suggest that these genes originate through a teleost‐specific whole genome duplication event. We found that Gper1a induced phosphorylation of mitogen‐activated protein kinase (MAPK) in 293T cells transfected with medaka Gper1s on exposure to the natural estrogen, 17β‐estradiol (E2) and a synthetic Gper1 agonist (G‐1), and treatment with both E2 and G‐1 also decreased the rate of spontaneous maturation in medaka oocytes. These findings show that the processes for oocyte growth and maturation are sensitive to estrogens and are possibly mediated through Gper1a in medaka. We also show that 17α‐ethinylestradiol (EE2), one of the most potent estrogenic endocrine‐disrupting chemicals, and bisphenol A (BPA, a weak environmental estrogen) augmented phosphorylation of MAPK through medaka Gper1s in 293T cells. Interestingly, however, treatment with EE2 or BPA did not attenuate maturation of medaka oocytes. Our findings support that Gper1‐mediated effects on oocytes are conserved among fish species, but effects of estrogenic endocrine‐disrupting chemicals on oocytes acting through Gper1 may be divergent among fish species.

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Estrogenic Regulation of Reproduction in Teleosts

Tomy

2021

Recent Updates in Molecular Endocrinology and Reproductive Physiology of Fish

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Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: Identification, evolutionary history and differential expression regulation

Cited by 35 publications

References 97 publications

The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

The expression of nuclear and membrane estrogen receptors in the European eel throughout spermatogenesis

Characterization of G protein‐coupled estrogen receptors in Japanese medaka, Oryzias latipes

Estrogenic Regulation of Reproduction in Teleosts

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