Three patterns of sensitization to mugwort, timothy, birch and their major allergen components revealed by Latent class analysis

Wu, Liting; Hou, Xiangqing; Luo, Wenting; Hu, Haisheng; Zheng, Xianhui; Chen, Yuemin; Cheng, Zhangkai J.; Huang, Chen; Sun, Baoqing

doi:10.1016/j.molimm.2022.03.009

Cited by 6 publications

(6 citation statements)

References 45 publications

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“…27 Similar results have been observed in China, with a sensitization rate of 82.4% for Bet v 1 in northern China 18 and 82.8% in our study, while the rate was less than 50% in southern China. 17 A gradient of sensitization rate is also observed among other birch pollen allergen components. While Bet v 1 predominates in the northern region, Bet v 2 and Bet v 4 are more prevalent in the southern area.…”

Section: Discussionmentioning

confidence: 95%

“…16,22 Our study has demonstrated that Bet v 1 is the predominant allergen component in northern China, which is consistent with the findings of previous studies conducted in Europe, Japan and South Korea. 17,18,[23][24][25][26][27][28][29] The regional differences in the birch pollen allergen sensitization rate are shown in Figure 4 including Japan, 25 Korea, 30 Italy, 24 Switzerland 3 , Czech, 26 Austria, 3 France, 3 Russia, 31 southern China. 17 A gradient of Bet v 1 sensitization rate was observed, with a higher prevalence in the northern region and a lower prevalence in the southern region.…”

Section: Discussionmentioning

confidence: 99%

“…17,18,[23][24][25][26][27][28][29] The regional differences in the birch pollen allergen sensitization rate are shown in Figure 4 including Japan, 25 Korea, 30 Italy, 24 Switzerland 3 , Czech, 26 Austria, 3 France, 3 Russia, 31 southern China. 17 A gradient of Bet v 1 sensitization rate was observed, with a higher prevalence in the northern region and a lower prevalence in the southern region. In Czech Republic, 26 89.9% of patients tested positive for Bet v 1, while in southern Italy, the proportion decreased to 58%.…”

Section: Discussionmentioning

confidence: 99%

“…6 In addition to those pollens, birch pollen allergy was comparable to that in Europe, with a prevalence of 11.3%. 3,6 Meanwhile, there is a relative lack of research on birch pollen allergy in our country, with only one study conducted in southern China 17 and two in northern China. 18,19 The previous studies had a restricted sample size and solely concentrated on Bet v 1, disregarding other birch pollen allergen components such as Bet v 2 and Bet v 4.…”

Section: Introductionmentioning

confidence: 99%

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Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Wang,

Chen,

Ding

et al. 2023

JAA

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To investigate the major allergen components associated with birch pollen allergy in northern China and elucidate clinical relevance to pollen food allergy syndrome (PFAS). Methods: Fifty-eight patients were recruited for a cross-sectional study and categorized into two groups: PFAS group and non-PFAS group, as well as apple allergy group and non-apple allergy group. The sIgE levels of birch pollen and its components, namely Bet v 1, Bet v 2, Bet v 4, and Bet v 6, were analyzed. Results: Among 58 participants, 44 individuals (75.9%) reported PFAS. 32 out of 44 (72.7%) participants reported apple allergy. Bet v 1 exhibited the highest sensitization rate at 82.8%, followed by Bet v 2 (29.3%) and Bet v 6 (1.7%). The combined sensitization rate for Bet v 1 and/or Bet v 2 was 93.1%. A total of 77.6% of the subjects demonstrated sensitization to single component, while 19.0% exhibited sensitization to two components. The sIgE levels of birch pollen and Bet v 1 were significantly elevated in PFAS group compared to non-PFAS group (p=0.001, p<0.001, respectively), as well as in apple-allergic and non-apple-allergic group (p<0.001, p<0.001, respectively). The optimal cut-off values for birch pollen and Bet v 1 sIgE were determined to be 7.09 kUA/L (with a sensitivity of 84.1% and specificity of 78.6%) and 5.11 kUA/L (with a sensitivity of 75.0% and specificity of 85.7%) when diagnosing PFAS. In terms of apple allergy, the optimal cut-off value were 9.40 kUA/L (with a sensitivity of 81.3% and specificity of 76.9%) and 6.53 kUA/L (with a sensitivity of 84.4% and specificity of 84.6%), respectively. Conclusion:The predominant sensitization pattern is mono-sensitization to Bet v 1, but when considering immunotherapy, Bet v 2 should also be taken into account. Bet v 1 serves as a valuable biomarker for diagnosing PFAS and apple allergy.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Wang,

Chen,

Ding

et al. 2023

JAA

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“…In previous studies, we reported an extensive cross-reaction between D. farina and D. pteronyssinus 11 ; C. pagurus , P. monodon , and B. germanica 12 ; milk and egg whites 10 , 13 . Thus, we can test positive for one of the above allergens and then easily deduce that the patient is also positive for the others 14 , 15 .…”

Section: Discussionmentioning

confidence: 99%

A study of allergen detection panel in Guangzhou, southern China based on real-world data from the past 7 years

Hu,

Huang,

Liao

et al. 2023

Sci Rep

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This study aims to reduce the cost of allergen testing for Guangzhou, China by limiting the number of allergens for which patients are tested, and provide a testing panel to improve diagnostic and therapeutic efficiency. This retrospective study of real-world data from 2012 to 2019 included 39,570 patients with suspected allergies in Guangzhou, southern China. All the patients were tested for one or more of the following allergens serum specific immunoglobulin E (sIgE): Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat dander, dog dander, Artemisia vulgaris, Aspergillus fumigatus, Alternaria alternata, Blattella germanica, egg whites, milk, wheat, peanuts, soybeans, Cancer pagurus, and Penaeus monodon by PhadiaCAP 1000. Totally, only the positive rates of allergens sIgE in D. farinae, D. pteronyssinus, milk, egg whites, B. germanica, C. pagurus, A. alternata, and P. monodon were > 10%, the other allergens were between 4–7%. Moreover, among the allergic diseases, dust mites exhibited the overall highest positive rate, followed by milk and B. germanica. In children, milk was the main allergen, whereas in adults, mites, cockroaches, shrimp, and crab allergens had higher positive rates. The optimal scale analysis shows that the multiple sensitization classification of patients can be divided into three categories: I D. farinae and D. pteronyssinus; II. C. pagurus, P. monodon, and B. germanica; III. Milk and egg whites. Generally, a panel including 4 allergens can detect > 90% of the potential allergy in this local population. In Guangzhou, southern China, D. farinae, milk, B. germanica, and A. alternata as a panel screening allergy for suspected allergic patients was suggested base on this study.

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Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China

Zhao,

Ma,

Wang

et al. 2024

Curr Allergy Asthma Rep

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Three patterns of sensitization to mugwort, timothy, birch and their major allergen components revealed by Latent class analysis

Cited by 6 publications

References 45 publications

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

A study of allergen detection panel in Guangzhou, southern China based on real-world data from the past 7 years

Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China

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