Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale

Abstract

Three previously undescribed chlorophenyl glycosides, (2,4,6‐trichloro‐3‐hydroxy‐5‐methoxyphenyl)methyl β‐D‐glucopyranoside (1), (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2) and 4‐chloro‐3‐methoxy‐5‐methylphenyl 6‐O‐(6‐deoxy‐β‐L‐mannopyranosyl)‐β‐D‐glucopyranoside (3) were obtained from Lilium regale. The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4‐dichloro‐3,5‐dimethoxyphenyl)methyl 6‐O‐β‐D‐glucopyranosyl‐β‐D‐glucopyranoside (2) can inhibit the proliferation of lung carcinoma A549 cells with an IC50 value of 29 μΜ.

Molecular Networking-Guided Isolation of Cycloartane-type Triterpenoids from Curculigo orchioides and Their Inhibitory Effect on Nitric Oxide Production

“…The rhizomes of Curculigo orchioides Gaertn. (Amaryllidaceae) have been used as a traditional folk medicine in Asia for the treatment of impotence, jaundice, asthma, decline in physical strength, and arthritis. − In the previous phytochemical studies of the genus Curculigo, phenolic compounds including chlorophenolic glycosides, − lignans, , and triterpenoidal saponins − have been reported as the main bioactive constituents. Various pharmacological investigations have revealed the broad biological activities of the extracts and isolates.…”