Three strategies for displaying the postcricoid space and pyriform sinus: A matched case‐controlled study of 50 patients

Zhu, Guanghao; Ou, Peng; Li, Shaohong; Wang, Shuhui; Li, Jiajia; Yin, Dandan; Peng, Xia; Yang, Tao; Tang, Qinglai; Yang, Xinming

doi:10.1111/coa.13256

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laryngeal cancers are easily directly inspected by flexible laryngoscopy. However, the examination of the hypopharynx often poses a challenge for clear visualization because of the cramped space and concealed location 3 . As a result, hypopharyngeal cancer is usually diagnosed at a relatively late stage.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival

Zhu

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

The link between differences in molecular expression and survival among advanced laryngeal (LSCC) and hypopharyngeal squamous carcinoma (HPSCC) remains unclear. Here, we applied the Surveillance, Epidemiology, and End Results (SEER) program, Isobaric tag for relative and absolute quantitation (iTRAQ) with Liquid chromatography-mass spectrometry (LC–MS/MS) proteomics data and The Cancer Genome Atlas (TCGA) related data to discover the possible disparities between HPSCC and LSCC. Our results showed a significantly worse 5-year overall-survival in HPSCC compared with LSCC before and after adjusting for clinical parameters. 240 differentially expressed proteins were enriched in molecular networks of cytoskeleton remodeling and antigen presentation. Moreover, HPSCC consisted of less T-central-memory cells, T-follicular-helper cells, TGF-β response, and CD4 + T memory resting cells, but more wound healing than LSCC. Furthermore, 9 mRNAs expression were significantly and independently correlated to overall survival in 126 HPSCC and LSCC patients, which was further validated in another cohort of head and neck cancers. These findings support that Immunity signatures as well as pathway networks that include cytoskeleton remodeling and antigen presentation may contribute to the observed differences in survival between HPSCC and LSCC.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival

Zhu

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

Modified Killian Method for Flexible Nasopharyngoscopic Observation of the Hypopharynx: A Systematic Review and Meta-Analysis

Liao,

Chi,

Kuo

et al. 2024

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Objective: Flexible nasopharyngoscopy is a common procedure for evaluating the hypopharynx. The modified Killian method has been reported to enhance visualization during this examination. The aim of this study was to compare the visibility of the hypopharynx using conventional and modified Killian methods. Methods: A systematic literature search was conducted in PubMed, EMBASE, and the Cochrane Library to identify studies that compared the visibility of the hypopharynx using the 2 methods. Comprehensive meta-analysis software was used to analyze the data. Studies that evaluated the overall hypopharyngeal visibility score and the visibility of the pyriform sinus, postcricoid region, and upper esophageal sphincter were included. Results: Five studies were included in the analysis. The pooled results showed that the modified Killian method significantly improved overall visibility score (SMD=1.09; 95% CI, 0.39–1.80) and complete visibility of the pyriform sinus, postcricoid region, and upper esophageal sphincter (log OR=3.83; 95% CI, 2.30–5.35; log OR=4.20; 95% CI, 3.21–5.19; log OR=3.38; 95% CI, 1.68–5.08). Conclusion: The modified Killian method is a valuable technique for improving hypopharyngeal visibility during flexible nasopharyngoscopy. This technique can enhance the detection of potential abnormalities or lesions, leading to better diagnostic accuracy and improved patient outcomes.

show abstract

JDHY3 Inhibits Hypopharyngeal Carcinoma Cell Proliferation and Promotes Apoptosis by Inhibiting the PI3K/AKT Pathway

Liu

Dai²,

Zhang

et al. 2023

ACAMC

View full text Add to dashboard Cite

Background: Jieduhuayu No.3 (JDHY3) is a modified Chinese herbal formula beneficial for treating hypopharyngeal carcinoma (HC), but its pharmacological mechanism is unknown. Objective: This study aimed to explore the mechanism of the herbal formula JDHY3 in inhibiting cell proliferation and promoting apoptosis in HC in vitro and in vivo. Methods: In this study, HC cells were treated with cisplatin and different concentrations of JDHY3. The apoptosis rate was detected by flow cytometry. Western blotting was used to detect the proteins related to cell proliferation and apoptosis. Afterward, the xenograft mouse model was established and treated with cisplatin and JDHY3. Mouse tumour volume was measured, and the tumour tissues were assessed by HE staining and immunohistochemistry. method: In this study, HC cells were treated with cisplatin and different concentrations of JDHY3. The apoptosis rate was detected by flow cytometry. Western blotting was used to detect the proteins related to cell proliferation and apoptosis. Afterwards, xenograft mouse model was established and treated with cisplatin and JDHY3. Mouse tumour volume was measured, and the tumour tissues were assessed by HE staining and immunohistochemistry. Results: JDHY3 significantly inhibited the proliferation of FaDu and Detroit-562 cells. In addition, JDHY3 significantly increased the apoptosis rate of HC cells and downregulated p-PI3K and p-Akt. In addition, JDHY3 upregulated the expression of the apoptosis-promoting proteins Bax, P53, and cleaved caspase-3. In addition, the expression of the antiapoptotic protein Bcl-2 was downregulated. Coincubation with SC79 attenuated the decrease in cell proliferation induced by JDHY3, further confirming that the proapoptotic effect of JDHY3 is associated with the inhibition of PI3K/Akt pathway activation. Conclusions: The results of in vivo experiments showed that JDHY3 could effectively inhibit the proliferation of HC cells, and HE staining showed that JDHY3 reduced the invasion of HC cells. Immunohistochemistry showed that the expression of P53 and cleaved caspase-3 was significantly increased in the tissues of the JDHY3-treated group. other: No others.

show abstract

Three strategies for displaying the postcricoid space and pyriform sinus: A matched case‐controlled study of 50 patients

Cited by 3 publications

References 8 publications

Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival

Proteomic analysis of hypopharyngeal and laryngeal squamous cell carcinoma sheds light on differences in survival

Modified Killian Method for Flexible Nasopharyngoscopic Observation of the Hypopharynx: A Systematic Review and Meta-Analysis

JDHY3 Inhibits Hypopharyngeal Carcinoma Cell Proliferation and Promotes Apoptosis by Inhibiting the PI3K/AKT Pathway

Contact Info

Product

Resources

About