Thrombin Based Photothermal‐Responsive Nanoplatform for Tumor‐Specific Embolization Therapy

Yin, Jiajia; Wang, Xiaorui; Sun, Xu; Dai, Hanming; Song, Xuejiao; Li, Buhong; Zhang, Yewei; Chen, Peng; Dong, Xiaochen

doi:10.1002/smll.202105033

Cited by 22 publications

(13 citation statements)

References 36 publications

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“…Especially for high activity drugs, it is hazardous for preleakage prior to target site even at trace amounts level. Yin et al synthesized a phase-change material (PCM) loaded with both thrombin (Thr) and photothermal reagents IR780 in tumor embolization therapy [ 37 ]. Thr rapidly forms clots in direct contact with blood because of strong coagulation, and this nonspecific embolism is extremely detrimental to normal tissues.…”

Section: Intelligent Lipid-based Vehicle Responded With Physical Acti...mentioning

confidence: 99%

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

et al. 2022

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Intelligent drug delivery system based on “stimulus-response” mode emerging a promising perspective in next generation lipid-based nanoparticle. Here, we classify signal sources into physical and physiological stimulation according to their origin. The physical signals include temperature, ultrasound, and electromagnetic wave, while physiological signals involve pH, redox condition, and associated proteins. We first summarize external physical response from three main points about efficiency, particle state, and on-demand release. Afterwards, we describe how to design drug delivery using the physiological environment in vivo and present different current application methods. Lastly, we draw a vision of possible future development.

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Section: Intelligent Lipid-based Vehicle Responded With Physical Acti...mentioning

confidence: 99%

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

et al. 2022

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“…Owing to the flexibility of polymers and the luminescence from fluorescent nanomaterials (e.g., carbon nanodots and MOFs), nanopolyhybrids can be employed in biosensing, bioimaging, and therapy tools. [172][173][174][175][176] For instance, a glucose-imprinted poly(N-isopropyl acrylamide-acrylamide-vinyl phenyl boronic acid)/nanosized carbon dot hybrid can reversibly change itself depending on the glu-cose concentration and convert biochemical signals to optical signals. The imprinted hybrid composite advanced glucose detection by improving the sensitivity and selectivity over a clinically relevant range of 0-30 mm at physiological pH, which is essential for diabetic monitoring.…”

Section: Advanced Medical Applicationsmentioning

confidence: 99%

Nanopolyhybrids: Materials, Engineering Designs, and Advances in Thermal Management

et al. 2023

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The fundamental requirements for thermal comfort along with the unbalanced growth in the energy demand and consumption worldwide have triggered the development and innovation of advanced materials for high thermal-management capabilities. However, continuous development remains a significant challenge in designing thermally robust materials for the efficient thermal management of industrial devices and manufacturing technologies. The notable achievements thus far in nanopolyhybrid design technologies include multiresponsive energy harvesting/conversion (e.g., light, magnetic, and electric), thermoregulation (including microclimate), energy saving in construction, as well as the miniaturization, integration, and intelligentization of electronic systems. These are achieved by integrating nanomaterials and polymers with desired engineering strategies. Herein, fundamental design approaches that consider diverse nanomaterials and the properties of nanopolyhybrids are introduced, and the emerging applications of hybrid composites such as personal and electronic thermal management and advanced medical applications are highlighted. Finally, current challenges and outlook for future trends and prospects are summarized to develop nanopolyhybrid materials.

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“…Therefore, PCMs show great potential for utilization as Th carriers. The Dong group developed PCM-based nanocarriers for the safe delivery and controllable release of thrombin (Thr) by coencapsulating IR780 and Thr within PCM via a resolidification approach [ 45 ] (Fig. 6 a).…”

Section: Thrombin-based Nanoparticles For Tumor Embolization Therapymentioning

confidence: 99%

Section: Thrombin-based Nanoparticles For Tumor Embolization Therapymentioning

confidence: 99%

Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy

Dong

Yang

et al. 2022

J Nanobiotechnol

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Tumor embolization therapy has attracted great attention due to its high efficiency in inhibiting tumor growth by cutting off tumor nutrition and oxygen supply by the embolic agent. Although transcatheter arterial embolization (TAE) is the mainstream technique in the clinic, there are still some limitations to be considered, especially the existence of high risks and complications. Recently, nanomaterials have drawn wide attention in disease diagnosis, drug delivery, and new types of therapies, such as photothermal therapy and photodynamic therapy, owing to their unique optical, thermal, convertible and in vivo transport properties. Furthermore, the utilization of nanoplatforms in tumor non-interventional embolization therapy has attracted the attention of researchers. Herein, the recent advances in this area are summarized in this review, which revealed three different types of nanoparticle strategies: (1) nanoparticles with active targeting effects or stimuli responsiveness (ultrasound and photothermal) for the safe delivery and responsive release of thrombin; (2) tumor microenvironment (copper and phosphate, acidity and GSH/H2O2)-responsive nanoparticles for embolization therapy with high specificity; and (3) peptide-based nanoparticles with mimic functions and excellent biocompatibility for tumor embolization therapy. The benefits and limitations of each kind of nanoparticle in tumor non-interventional embolization therapy will be highlighted. Investigations of nanoplatforms are undoubtedly of great significance, and some advanced nanoplatform systems have arrived at a new height and show potential applications in practical applications.

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Thrombin Based Photothermal‐Responsive Nanoplatform for Tumor‐Specific Embolization Therapy

Cited by 22 publications

References 36 publications

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation

Nanopolyhybrids: Materials, Engineering Designs, and Advances in Thermal Management

Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy

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