Thrombocytopenia After Aortic Valve Replacement With Freedom Solo Bioprosthesis: A Propensity Study

Piccardo, Alessandro; Ruşinaru, Dan; Petitprez, B.; Marticho, Paul; Vaida, Ioana; Tribouilloy, Christophe; Caus, Thierry

doi:10.1016/j.athoracsur.2010.01.040

Cited by 37 publications

(44 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yerebakan et al were the first to report their experiences in an institutional report regarding the remarkable decrease in platelet counts observed after using the Sorin Freedom valve since 2005 (10) . In this study, the authors presented the average platelet counts that they obtained daily after the operation and they made statistical adjustment for clopidogrel use, which was more common among patients receiving the Freedom Solo valve.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism underlying the relationship between TCP and the Freedom Solo valve remains unknown. Some authors have attributed this relationship to the commercial release and preparation of the valve before the operation (10,11) . The Freedom Solo valve does not necessitate rinsing before implantation because it is provided by the manufacturer and the valve is detoxified with homocysteic acid during its preparation before implantation.…”

Section: Discussionmentioning

confidence: 99%

“…Van Straten et al reported in a large series of patients that postoperative TCP was not directly associated with the implantation of the Freedom Solo valve; however, in controversy, a lower platelet count within the first 5 postoperative days was more common in patients receiving a CarpentierEdwards Perimount bioprosthesis or Medtronic Freestyle bioprosthesis (19) . Interestingly, several studies in recent years have focused on the relationship between TCP and the Freedom Solo valve (10)(11)(12)(13)(14)(15)(16)(17)(18) . In our study, because the patients for whom the Freedom Solo and Pericarbon Freedom valves were used had similar baseline features to those for whom other types of valves were used, our results support the presence of an ambiguous relationship that has been repeatedly announced.…”

Section: Discussionmentioning

confidence: 99%

“…Sorin Freedom Solo and Sorin Pericarbon Freedom are the latest generation of stentless aortic tissue valves, which have structural flexibility, an easy single-suture implantation technique and excellent haemodynamics (8,9) . However, postoperative thrombocytopaenia (TCP) is a potentially serious problem following implantation, and recent reports have suggested a strong relationship (10)(11)(12)(13)(14)(15)(16)(17)(18) . Nevertheless, previous studies have not shown any significant mortality or morbidity effect or association with adverse outcomes in patients with TCP.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation

Sarikaya¹

2017

Kosuyolu Heart Journal

View full text Add to dashboard Cite

Introduction:We aimed to determine whether thrombocytopaenia (TCP) is associated with postoperative complications in patients undergoing bioprosthetic aortic valve replacement.Patients and Methods: Clinical records of 39 consecutive patients undergoing bioprosthetic aortic valve replacement for aortic stenosis were reviewed. Patients were divided into 2 groups based on whether they had TCP or not within 7 days after the operation [TCP (+), 9 patients and TCP (-), 30 patients]. TCP was defined as a platelet count less than 50 × 10 9 /L.Results: Both the groups were similar with regard to baseline clinical characteristics and operative variables. Stentless bioprosthesis was used in 16 patients (41.02%). The use of Sorin Pericarbon Freedom was significantly more common in the TCP (+) group. Postoperative complications such as the removal time of the drainage tube, intensive care unit (ICU) stay and acute renal failure were significantly higher in the TCP (+) group. Overall, 30-day mortality occurred in 3 (7.7%) patients, and the difference between the groups was not statistically significant. Conclusion:Postoperative TCP may be associated with a substantial threat for the postoperative status of patients undergoing bioprosthetic valve replacement. The issue is still subject to further research until the exact mechanism underlying its occurrence is elucidated.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation

Sarikaya¹

2017

Kosuyolu Heart Journal

View full text Add to dashboard Cite

show abstract

“…Many research found that the use of this valve was associated with postoperative thrombocytopenia. (13,14,15,16) However, research conducted by Beholz et al found none of the study reported severe thrombocytopenia as an adverse event. (17) Hence, in spite of increase in the usage of FS valve, there is still controversy regarding its complication.…”

Section: Introductionmentioning

confidence: 95%

Early postoperative hemodynamics and clinical outcomes of patients receiving freedom solo aortic calve replacement; the Asian Experience

Amir¹,

Hassan²,

Mokhtar³

et al. 2013

ejcm

View full text Add to dashboard Cite

SummaryAim: Background and aim of the study: Freedom SOLO (FS) valve (Sorin Group, Saluggia, Italy) is a stentless aortic valve bioprosthesis that use a single running suture line implanted in supra-annular position. Current study aims to assess the early postoperative hemodynamics and clinical outcomes of patients receiving FS aortic valve replacement (AVR).Methodology: 4 patients (2 male; 2 female; mean age 49.25 ± 23.78 years; range: from 25 to 73) who underwent AVR with FS valve in a single center were enrolled in the study. 2 patients underwent AVR for aortic stenosis and 2 patients for aortic regurgitation. Clinical and biological outcomes were recorded. Echocardiographic parameters were compared between preoperative and 5 months postoperative observation.Results: There was no early mortality reported. Late death was reported in one patient which was non valve related. There were 2 patients who developed early postoperative complication but it was not attributed to the valve itself. The mean transvalvular pressure gradient was 26.50 ± 11.90 mmHg preoperatively and 15.25 ± 10.11 mmHg postoperatively. The mean aortic valve area (AVA) for patients having stenosis improved from 0.74 ± 0.23 cm2 preoperatively to 1.50 ± 0.57 cm2 postoperatively. Preoperatively, the mean left ventricular ejection fraction (LVEF) was 65.75 ± 6.29 % and postoperatively 61.25+_11.84 %. The mean cross-clamp time (CCT) for isolated valve replacement was 80.5 ± 21.92 minutes and 147.00 ± 26.87 minutes. The mean lowest postoperative platelet count recorded was 24.50 ± 6.19 (x109/L). The mean platelet count at discharge was 128.75 ±10.11 (x109/L). Conclusion:The result demonstrated good short-term clinical and hemodynamic outcomes in patients underwent FS aortic valve replacement. However, the study also showed the occurrence of severe thrombocytopenia after FS valve implantation.Keywords: freedom solo valve, thrombocytopenia, aortic valve replacement

show abstract

Major thrombocytopenia after balloon‐expandable transcatheter aortic valve replacement: Prognostic implications and comparison to surgical aortic valve replacement

Jilaihawi

Doctor

Chakravarty

et al. 2014

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

Thrombocytopenia After Aortic Valve Replacement With Freedom Solo Bioprosthesis: A Propensity Study

Cited by 37 publications

References 10 publications

Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation

Evaluation of Thrombocytopaenia-Related Complications After Bioprosthetic Aortic Valve Implantation

Early postoperative hemodynamics and clinical outcomes of patients receiving freedom solo aortic calve replacement; the Asian Experience

Major thrombocytopenia after balloon‐expandable transcatheter aortic valve replacement: Prognostic implications and comparison to surgical aortic valve replacement

Contact Info

Product

Resources

About