Thrombocytopenia associated with hepatitis C viral infection

Nagamine, Takahiko; Ohtuka, Tosiyuki; Takehara, Ken; Arai, Takayuki; Takagi, Hitoshi; Mori, Masatomo

doi:10.1016/s0168-8278(96)80021-3

Cited by 196 publications

(184 citation statements)

References 15 publications

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“…syndrome (7,14). The prevalence of thrombocytopenia (<10×10 4 /mm 3 ) in Sjögren's syndrome is reported to be 3.6% to 7.1%, which is similar to that in CHC (2,7,14). The degree of thrombocytopenia in Sjögren's syndrome is usually mild without need for treatment.…”

Section: Discussionmentioning

confidence: 64%

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Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

et al. 2005

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A 74-year-old woman with Sjögren's syndrome and chronic hepatitis C (CHC) was admitted to our hospital in October 2003 for treatment of diabetes mellitus. She had the past history of recurrent thrombocytopenia, which was proven to be due to peripheral destruction. Although she had been diagnosed with hypertrophic cardiomyopathy (HCM) for 2 years, she had never felt palpitation. She suddenly died probably of fatal arrhythmia related to HCM during the last hospitalization.

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Section: Discussionmentioning

confidence: 64%

“…HCV can also cause various extrahepatic manifestations such as thrombocytopenia, cardiomyopathy, and salivary gland disorders (2)(3)(4). Although the presence of HCV at these extrahepatic organs was demonstrated (3,5,6), the mechanism of how HCV induce these disorders is not known.…”

Section: Introductionmentioning

confidence: 99%

Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

et al. 2005

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“…Severe thrombocytopenia, defined as a platelet count of less than 50 Â 10 9 /L, is reported in 9% of HCV-infected patients [3]. In addition, thrombocytopenia associated with HCV infection can be seen even in the absence of overt liver disease.…”

Section: Discussionmentioning

confidence: 99%

“…Thrombocytopenia is a well-documented complication of hepatitis C virus (HCV) infection [1][2][3][4]. In patients with cirrhosis and portal hypertension, thrombocytopenia is thought to be due to hypersplenism.…”

Section: Introductionmentioning

confidence: 99%

Treatment of immune thrombocytopenia associated with interferon therapy of hepatitis C with the anti-CD20 monoclonal antibody, rituximab

Weitz

2005

Am. J. Hematol.

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This case report describes a patient with hepatitis C virus infection responding to pegylated INF/ribaviron therapy, who developed immune thrombocytopenia. The severe thrombocytopenia failed to resolve with cessation of the peg-IFN/ribaviron. Because of rising hepatitis C virus RNA levels and evidence of rising serum transaminases, the patient was treated with rituximab, anti-CD20 humanized monoclonal antibody. After treatment with rituximab, the patient's platelet count normalized and the patient was able to resume the pegylated IFN/ribaviron. The patient's hepatitis C virus RNA levels decreased, and the serum transaminases normalized without impairment of hepatic function or recurrence of the thrombocytopenia. Am.

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“…Aunque no se conocen los mecanismos involucrados en el desarrollo de estos anticuerpos antiplaquetarios, se ha observado que el VHC tiene capacidad de unión a las plaquetas, al igual que el VIH (24)(25)(26)(27); esta característica del virus favorecería el desarrollo de nuevos antígenos sobre la superficie de las plaquetas mediante la modificación en la conformación de las glucoproteínas plaquetarias, lo cual propiciaría el desarrollo de anticuerpos autorreactivos (25,26). Otros mecanismos inmunoló-gicos que podrían estar involucrados en el desarrollo de esta púrpura trombocitopénica, son el depósito de complejos inmunes inespecíficos en la superficie plaquetaria (19,31) o la presencia de anticuerpos anticardiolipina (32), lo cual nos demuestra el carácter complejo de esta etiología.…”

Section: Hepatitis Viralunclassified

Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

et al. 2011

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Introducción. La trombocitopenia es un fenómeno frecuente en las infecciones virales. Uno de los mecanismos propuesto como posible explicación de su desarrollo es la destrucción plaquetaria periférica mediada por anticuerpos antiplaquetarios. Objetivo. Revisar los resultados de los trabajos originales que existen en la literatura sobre infección viral y anticuerpos antiplaquetarios en humanos, y su efecto sobre el recuento total de plaquetas. Materiales y métodos. Se hizo una búsqueda en PubMed empleando la combinación de términos: "viral infection (OR Virus diseases) AND antibody antiplatelet (OR thrombocytopenia); y antibody antiplatelet AND HIV (OR Measles, OR Dengue, OR Chickenpox OR varicella, OR Epstein Barr, OR Mumps, OR Rubella". Se obtuvieron 218 referencias, de las cuales, 65 correspondían al objetivo de la revisión. Resultados. En la búsqueda se encontró que la trombocitopenia mediada por anticuerpos antiplaquetarios se ha documentado en infecciones virales por VIH, sarampión, dengue, varicelazóster, Epstein-Barr, parotiditis y rubéola. La presencia de anticuerpos antiplaquetarios en infecciones virales por VIH, virus de Epstein-Barr y dengue, se ha asociado con la presencia de la trombocitopenia y con la gravedad de la enfermedad. Conclusiones. Aunque la aparición de anticuerpos antiplaquetarios no se considera el único mecanismo que explica la trombocitopenia desarrollada en las infecciones virales mencionadas, de acuerdo con la literatura científica disponible, su presencia se asocia con la gravedad de la trombocitopenia y con potenciales implicaciones clínicas en los pacientes.Palabras clave: virosis, anticuerpos, plaquetas, trombocitopenia, humanos. Roll of antibodies antiplatelets in viral infection: a systematic review of literatureIntroduction. Thrombocytopenia is a frequent phenomenon in viral infections. Peripheral platelet destruction mediated by anti-platelet antibodies has been one of the proposed causal mechanisms. Objective. Results were collected and analyzed from published studies on associations of human viral infections on anti-platelet antibodies and total platelet counts. Materials and methods. A PubMed search was conducted using the following terms: Viral infection (OR Virus diseases) AND antiplatelet antibody (OR thrombocytopenia) AND HIV (OR measles OR dengue OR chickenpox OR varicella OR Epistein Barr OR mumps OR rubella). Two hundred eighteen reference hits were obtained, 65 of which were relevant to this review. Results. Antiplatelet antibody-mediated thrombocytopenia has been documented in cases of HIV, measles, dengue, chickenpox, Epstein-Barr, mumps and rubella. Moreover, the presence of these antibodies has been associated with severity the disease and thrombocytopenia in viral infections. Conclusions. Although the presence of antiplatelet antibodies was not the only mechanism for explaining the thrombocytopenia developed in these viral infections, their presence was associated with severity of thrombocytopenia and with the clinical presentation of these patients.

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Thrombocytopenia associated with hepatitis C viral infection

Cited by 196 publications

References 15 publications

Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

Sjoegren's Syndrome Associated with Chronic Hepatitis C, Severe Thrombocytopenia, Hypertrophic Cardiomyopathy, and Diabetes Mellitus

Treatment of immune thrombocytopenia associated with interferon therapy of hepatitis C with the anti-CD20 monoclonal antibody, rituximab

Papel de los anticuerpos antiplaquetarios en la infección viral: una revisión sistemática de la literatura

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