Thromboelastography: Where Is It and Where Is It Heading?

Srinivasa, Venkatesh; Gilbertson, Lesley; Bhavani-Shankar, Kodali

doi:10.1097/00004311-200101000-00005

Cited by 55 publications

(30 citation statements)

References 23 publications

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“…In the past it was criticized for being too dependent on manual procedures and for its results being excessively operator dependent (8,(17)(18)(19)(20)22,23,30,31). However, the recent development of computerized interfaces has addressed some of these limitations and has led to a renewed interest in TEG ® , particularly to guide blood transfusion practices (7,22,31). Our original goal, however, was not to evaluate the reliability of TEG ® as a laboratory test per se, but rather its potential clinical application in trauma care.…”

Section: Discussionmentioning

confidence: 99%

Normal range values for thromboelastography in healthy adult volunteers

Scarpelini¹,

Rhind²,

Nascimento³

et al. 2009

Braz J Med Biol Res

153

140

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Section: Discussionmentioning

confidence: 99%

Normal range values for thromboelastography in healthy adult volunteers

Scarpelini¹,

Rhind²,

Nascimento³

et al. 2009

Braz J Med Biol Res

153

140

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“…33 However, it does not measure the effect of aspirin, thienopyridines (P2Y12 platelet receptor inhibitors), or low-molecular-weight heparin. Thromboelastography provides a global assessment of hemostatic function in whole blood, preserving the interplay between erythrocytes, platelets, coagulation factors, and fibrinogen.…”

Section: Thromboelastographymentioning

confidence: 99%

Pathophysiology of Bleeding and Clotting in the Cardiac Surgery Patient

et al. 2010

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“…Thromboelastography has been in use since the 1940’s but recent advances in computer technology have made this technique more practical 8,9 . In TEG ™ the dynamic mechanical forces occurring during clot formation and lysis are transduced into electrical signals that can be monitored by computer 9 .…”

Section: Introductionmentioning

confidence: 99%

Iodinated Contrast Does Not Alter Clotting Dynamics in Acute Ischemic Stroke as Measured by Thromboelastography

McDonald¹,

Archeval-Lao²,

Cai³

et al. 2014

Stroke

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Background and Purpose Iodinated contrast agents used for computed tomography angiography (CTA) may alter fibrin fiber characteristics and decrease fibrinolysis by tissue plasminogen activator (tPA). Thromboelastography (TEG™) measures the dynamics of coagulation and correlates with thrombolysis in acute ischemic stroke (AIS) patients. We hypothesized that receiving CTA prior to tPA will not impair thrombolysis as measured by TEG™. Methods AIS patients receiving 0.9 mg/kg tPA within 4.5 hours of symptom onset were prospectively enrolled. For CTA, 350 mg/dL of iohexol or 320 mg/dL of iodixanol at a dose of 2.2 ml/kg was administered. TEG™ was measured prior to tPA and 10-minutes after tPA bolus. CTA timing was left to the discretion of the treating physician. Results Of 136 AIS patients who received tPA, 47 had CTA prior to tPA bolus, and 42 had either CTA following tPA and post-tPA TEG™ draw or no CTA (non-contrast group). The median change in clot lysis (LY30) following tPA was 95.3% in the contrast group vs. 95.0% in the non-contrast group (p = 0.74). Thus, tPA-induced thrombolysis did not differ between contrast and non-contrast groups. Additionally, there was no effect of contrast on any pre-tPA TEG™ value. Conclusions Our data do not support an effect of iodinated contrast agents on clot formation or tPA activity.

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Thromboelastography: Where Is It and Where Is It Heading?

Cited by 55 publications

References 23 publications

Normal range values for thromboelastography in healthy adult volunteers

Normal range values for thromboelastography in healthy adult volunteers

Pathophysiology of Bleeding and Clotting in the Cardiac Surgery Patient

Iodinated Contrast Does Not Alter Clotting Dynamics in Acute Ischemic Stroke as Measured by Thromboelastography

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