Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery

Nakayama, Yushi; Nakajima, Yasufumi; Tanaka, Kenichi A.; Sessler, Daniel I.; Maeda, Shoichi; Iida, Jun; Ogawa, Satoshi; Mizobe, Toshiki

doi:10.1093/bja/aeu339

Cited by 165 publications

(138 citation statements)

References 42 publications

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“…Fifteen trials that randomised a total of 8737 participants met the inclusion criteria and were included in the analysis. 112,129,[135][136][137][138][139][140][141][142][143][144][145][146][147] Two of the included studies were published in abstract form. 139,144 The two review authors (GJM, GFS) were in agreement on the selection of included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Random sequence generation was adequate in four trials 112,138,141,146 and unclear in eight trials. [135][136][137]139,140,143,144,147 Two trials had a high risk of bias for this domain.…”

Section: Sequence Generationmentioning

confidence: 98%

“…137,141 The sample size ranged from 22 143 to 7402 129 participants. The largest trial, 129 which enrolled more participants (n = 7402) than all of the other trials, used a multicentre stepped-wedge cluster RCT design.…”

Section: Included Studiesmentioning

confidence: 99%

“…129 and according to clinical judgement alone in one trial. 137 Ten trials provided data on the length of follow-up, 112,129,136,138,140,141,143,144,146,147 which ranged from 24 hours to 3 years.…”

Section: Included Studiesmentioning

confidence: 99%

“…There was evidence of blinding of participants and clinical staff caring for participants in two trials, 135,146 unclear evidence in five trials [139][140][141]143,145 and evidence of lack of blinding in seven trials. …”

Section: Blinding Of Participants and Personnelmentioning

confidence: 99%

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Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Murphy

Mumford

Rogers

et al. 2017

Programme Grants Appl Res

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This report should be referenced as follows:Murphy GJ, Mumford AD, Rogers CA, Wordsworth S, Stokes EA, Verheyden V, et al. Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials. Programme Grants Appl Res 2017;5(17). Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10384. The contractual start date was in July 2008. The final report began editorial review in July 2016 and was accepted for publication in April 2017. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not ...

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Section: Resultsmentioning

confidence: 99%

“…Random sequence generation was adequate in four trials 112,138,141,146 and unclear in eight trials. [135][136][137]139,140,143,144,147 Two trials had a high risk of bias for this domain.…”

Section: Sequence Generationmentioning

confidence: 98%