Thrombolysis with recombinant human tissue-type plasminogen activator during instability in coronary artery disease: Effect on myocardial ischemia and need for coronary revascularization

Karlsson, Jan‐Erik; Berglund, Ulf; ̈rkholm, Anders Bjo; Ohlsson, Jan; Swahn, Eva; Wallentin, Lars

doi:10.1016/0002-8703(92)90052-w

Cited by 22 publications

(8 citation statements)

References 42 publications

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“…Fibrinolytic treatment has been shown to decrease the amount of intracoronary thrombus and to significantly improve survival in acute coronary syndromes in patients with ST-segment elevation [143] . In contrast in several studies conducted with streptokinase, APSAC, T-PA or urokinase a deleterious effect has consistently been observed in patients with unstable angina [144][145][146][147] . The risk of death and myocardial infarction in a pooled series of 2859 patients was 9•8% in the fibrinolytic group and 6•9% in the control group.…”

Section: Fibrinolytic Treatmentmentioning

confidence: 80%

Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology Recommendations of the Task Force of the European Society of Cardiology

Bertrand¹

2000

European Heart Journal

402

149

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The Task Force on Management of Acute Coronary Syndromes without persistent ST-segment elevation was created by the Committee for Scientific and Clinical Initiatives on 18 October 1998 after formal approval by the Board of the European Society of Cardiology. The composition of the Task Force was proposed by Dr Michel E. Bertrand and was approved by the Board of the European Society of Cardiology. The document was extensively revised and circulated to the members of the Committee for Scientific and Clinical Initiatives, to the Members of the Board and to the following reviewers: J. Adgey (U.K.), J. P. Bassand (F), G. Breithardt (D), J. L. Lopez-Sendon (E), L. Rydén (S), C. Stefanadis (GR). After further revision, it was submitted for approval to the Committee for Scientific and Clinical Initiatives (Chairman: J. P. Bassand (F)). The Task Force report was entirely supported financially by the European Society of Cardiology and was developed without any involvement of pharmaceutical companies.

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Section: Fibrinolytic Treatmentmentioning

confidence: 80%

Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology Recommendations of the Task Force of the European Society of Cardiology

Bertrand¹

2000

European Heart Journal

402

149

View full text Add to dashboard Cite

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“…Changes in plasminogen activator inhibitor 1 and tissue-type plasminogen activator (PLAT gene) [37] were detected during exercise in patients with coronary artery disease. Karlsson et al [38] argued that there might be a role of plasma and tissue-type plasminogen activator in coronary atherosclerosis, suggesting that treatment with recombinant tissue-type plasminogen activator (PLAT), in unstable coronary artery disease in men reduced myocardial ischemia.…”

Section: Resultsmentioning

confidence: 99%

Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease

Zhang

Tai

et al. 2012

PLoS ONE

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Predicting candidate genes using gene expression profiles and unbiased protein-protein interactions (PPI) contributes a lot in deciphering the pathogenesis of complex diseases. Recent studies showed that there are significant disparities in network topological features between non-disease and disease genes in protein-protein interaction settings. Integrated methods could consider their characteristics comprehensively in a biological network. In this study, we introduce a novel computational method, based on combined network topological features, to construct a combined classifier and then use it to predict candidate genes for coronary artery diseases (CAD). As a result, 276 novel candidate genes were predicted and were found to share similar functions to known disease genes. The majority of the candidate genes were cross-validated by other three methods. Our method will be useful in the search for candidate genes of other diseases.

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“…In unstable coronary artery disease, the prevalencepretest likelihood -of coronary lesions at coronary angiography is about 90% [1,2,21]. Therefore, the aim of the test is not to identify the existence of core- Table 2 and Fig.…”

Section: Discussionmentioning

confidence: 99%

“…This trial evaluated the effects of intravenous recombinant human tissue-type plasminogen activator on the development of myocardial ischemia or myocardial infarction and the need for coronary revascularisation in men with unstable coronary artery disease [21]. The definition of unstable coronary artery disease was either non-Q-wave myocardial infarction or unstable angina pectoris.…”

Section: Patientsmentioning

confidence: 99%

Additional value of thallium-201 SPECT to a conventional exercise test for the identification of severe coronary lesions after an episode of unstable coronary artery disease

et al. 1995

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The additional value of thallium-201 SPECT to a conventional exercise test for the identification of patients with severe coronary lesions was evaluated in 170 men, one month after an episode of unstable coronary artery disease. Severe coronary lesions at coronary angiography--defined as three vessel disease, left main stenosis or proximal left anterior descending artery stenosis as part of two vessel disease--were observed in 45.9%. In the SPECT image, the left ventricular myocardium was divided into nine segments and each segment was classified as either normal (= 0), reduced uptake (= 1) or uptake defect (= 2). The sum of gradings in all segments post-exercise was denoted "SPECT score". The patients were divided into nine different groups regarding ST-depression during exercise (no ST-depression, ST-depression in 1-2 leads or > or = 3 leads) and "SPECT score" (no SPECT score, 1-3 scores or > or = 4 scores). Severe coronary lesions were, in 68% identified by SPECT score > or = 4 and in 65% by ST-depression in > or = 1 lead at exercise test. The specificity for identification of severe coronary lesions was, for both tests, 65%. SPECT score > or = 4 and/or ST-depression in > or = 3 leads identified 82% of the patients with severe coronary lesions with a specificity of 63%. Furthermore, SPECT score > or = 3 identified more patients with isolated proximal left anterior descending artery stenosis than ST-depression alone at exercise test.

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Thrombolysis with recombinant human tissue-type plasminogen activator during instability in coronary artery disease: Effect on myocardial ischemia and need for coronary revascularization

Cited by 22 publications

References 42 publications

Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology Recommendations of the Task Force of the European Society of Cardiology

Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology Recommendations of the Task Force of the European Society of Cardiology

Predicting Candidate Genes Based on Combined Network Topological Features: A Case Study in Coronary Artery Disease

Additional value of thallium-201 SPECT to a conventional exercise test for the identification of severe coronary lesions after an episode of unstable coronary artery disease

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