Thrombophlébite cérébrale : une complication rare de l’infection aiguë à cytomégalovirus

Périssé, André Reynaldo Santos; Sahuc, P.; Wybrecht, D.; Joubert, C.; Gaillard, Thomas; Dagain, Arnaud; Montcriol, Ambroise; Alla, P.; Faivre, Anthony

doi:10.1016/j.revmed.2013.04.001

Cited by 5 publications

(11 citation statements)

References 13 publications

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“…References from each report were further reviewed for additional reports. Overall, 78 reports concerning 113 patients were reviewed [ 1 – 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…Mean age of reported patients is 41.7 ±14.6 years (range: 17–83 years) [ 1 – 18 ]. Overall, the female-male ratio is 1: 1 in all reported patients.…”

Section: Epidemiologymentioning

confidence: 99%

“…The first reported patients with thrombosis and acute CMV infection in the mid 1980s and in the early 1990s were mainly immunocompromised – HIV patients and transplant recipients. Since the mid 1990s, most reported patients have been immunocompetent [ 1 – 18 ]. Acute CMV infection has been considered a benign infection in immunocompetent patients for many years; hence, these trends in reporting possibly reflect the increasing awareness of physicians about thrombosis associated with acute CMV infection in immunocompetent patients as well [ 38 ].…”

Section: Immunological Statusmentioning

confidence: 99%

“…According to published reports, most patients with thrombosis and acute CMV infection are immunocompetent ( n = 79; 69.9%). Among 34 immunocompromised patients, 14 (41.2%) patients were solid organ recipients, 8 (23.5%) patients had HIV infection, 6 (17.6%) patients had been taking steroids and/or immunosuppressant agents on a regular basis, 4 (11.8%) patients had active malignancy, 1 (2.9%) patient had undergone splenectomy, and 1 (2.9%) patient has had severe burns [ 1 – 18 ].…”

Section: Immunological Statusmentioning

confidence: 99%

“…Six (5.3%) patients had acute CMV infection without clinical manifestations of CMV disease, e.g., diagnosed by means of serology tests and/or by markers of viremia tested in the course of investigating fever of unknown origin. Other reports are incomplete [ 1 – 18 ].…”

Section: Cytomegalovirus Infection Characteristicsmentioning

confidence: 99%

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State of the art paper Thrombosis associated with acute cytomegalovirus infection: a narrative review

Sherman¹,

Eytan²,

Justo³

2014

aoms

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Thrombosis associated with acute cytomegalovirus infection has been reported many times in the literature since the mid 1980s – mainly in case reports and in small case series, but also in four controlled studies. Still, many physicians are unaware of this association although acute cytomegalovirus infection diagnosis in a thrombosis patient may warrant antiviral therapy and may affect anticoagulation therapy duration. Accordingly, the clinical characteristics of patients with thrombosis and acute cytomegalovirus infection are reviewed, and the current knowledge concerning this unique association is presented herein. We believe it is time to add acute cytomegalovirus infection to the list of thrombosis triggers.

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“…References from each report were further reviewed for additional reports. Overall, 78 reports concerning 113 patients were reviewed [ 1 – 18 ].…”

Section: Methodsmentioning

confidence: 99%

“…Mean age of reported patients is 41.7 ±14.6 years (range: 17–83 years) [ 1 – 18 ]. Overall, the female-male ratio is 1: 1 in all reported patients.…”

Section: Epidemiologymentioning

confidence: 99%

Section: Immunological Statusmentioning

confidence: 99%

Section: Immunological Statusmentioning

confidence: 99%

Section: Cytomegalovirus Infection Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

State of the art paper Thrombosis associated with acute cytomegalovirus infection: a narrative review

Sherman¹,

Eytan²,

Justo³

2014

aoms

View full text Add to dashboard Cite

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Risk factors of venous thrombo-embolism during cytomegalovirus infection in immunocompetent individuals. A systematic review

Ceccarelli

Rullo

Nunnari

2018

Eur J Clin Microbiol Infect Dis

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Most of the effects and complications of cytomegalovirus (CMV) infection are still unknown, even though its tropism for the endothelium has been extensively investigated. In fact, CMV is suspected to be a cause of venous thrombo-embolism (VTE) since 1974, but there is still no consensus about the management of CMV-related thrombosis and how to prevent it. Cytomegalovirus-related thrombosis has been reported mostly in immunocompromised patients, rarely in immunocompetent individuals. In order to identify potential risk factors of CMV-related thrombosis, we performed a systematic review of the literature regarding immunocompetent patients with cytomegalovirus infection and thrombosis. We found 115 cases with a mean age of 37.36 years (SD ± 16.43 years). Almost half the female patients were assuming EP contraception at the time of the event, and almost half the patients were affected by a coagulation disorder. Interestingly, just two women and four men had no risk factor for thrombosis other than the CMV infection at the time of the event. In conclusion, coagulation disorders and EP contraception have to be taken into a great deal of consideration in patients with CMV infection, since they could be important risk factors for VTE. Knowing the correlation with coagulation disorders, the use of anticoagulation drugs cannot be considered overtreatment. It was not feasible to determine the usefulness of an antiviral treatment. Further studies, even randomized ones, are required to determine the usefulness of antiviral drugs and the real prevalence of CMV-related VTE.

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Thromboses veineuses cérébrales multiples révélatrices d’une infection à VIH

et al. 2015

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Thrombophlébite cérébrale : une complication rare de l’infection aiguë à cytomégalovirus

Cited by 5 publications

References 13 publications

State of the art paper Thrombosis associated with acute cytomegalovirus infection: a narrative review

State of the art paper Thrombosis associated with acute cytomegalovirus infection: a narrative review

Risk factors of venous thrombo-embolism during cytomegalovirus infection in immunocompetent individuals. A systematic review

Thromboses veineuses cérébrales multiples révélatrices d’une infection à VIH

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