Thromboplastin Activity in Amniotic Fluid

Omsjø, Ivar H.; Øian, Pål; Maltau, Jan Martin; Osterud, B

doi:10.1159/000299000

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…Similarly, high TF concentrations have been detected in the fetal membranes (mainly the amnion) and amniotic fluid ( de Boer et al, 1989 ; Uszyński et al, 2001 ; Lockwood et al, 1991 ; Omsjø et al, 1985 ; Creter, 1977 ). TFPI has been found in amniotic fluid as well ( Uszyński et al, 2001 ), but it is not clear if the presence of TF and its natural inhibitor is related to coagulation per se or is somehow connected with embryonic development ( Carmeliet et al, 1996 ).…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 97%

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Mastrolia

Mazor

Loverro

et al. 2014

PeerJ

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Obstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e., infection, inflammation, thrombosis, endocrine disorder, immunologic rejection, genetic, and environmental), therefore, they may be regarded as syndromes. Placental vascular pathology and increased thrombin generation were reported in all of these obstetrical syndromes. Moreover, elevated concentrations of thrombin-anti thrombin III complexes and changes in the coagulation as well as anticoagulation factors can be detected in the maternal circulation prior to the clinical development of the disease in some of these syndromes. In this review, we will assess the changes in the hemostatic system during normal and complicated pregnancy in maternal blood, maternal–fetal interface and amniotic fluid, and describe the contribution of thrombosis and vascular pathology to the development of the great obstetrical syndromes.

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Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 97%

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Mastrolia

Mazor

Loverro

et al. 2014

PeerJ

View full text Add to dashboard Cite

show abstract

“…The principal anticoagulant mechanism inhibiting TF activation pathway is tissue factor pathway inhibitor (TFPI), which mRNA is highly expressed in the macrophages in the villi in term placenta 19 . Similarly, high TF concentrations have been detected in the fetal membranes (mainly the amnion) and amniotic fluid 7,[20][21][22][23] . TFPI has been found in amniotic fluid as well 20 , but it is not clear if the presence of TF and its natural inhibitor is related to coagulation per se or is somehow connected with embryonic development 24 .…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 96%

“…During normal pregnancy, there is an increase in the amniotic fluid TF concentration 7,[20][21][22][23] . In .…”

Section: Hemostatic Changes In the Amniotic Fluid Of Women With Obstementioning

confidence: 99%

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Mastrolia

Mazor

Loverro

et al. 2014

Preprint

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View the peer-reviewed version (peerj.com/articles/653), which is the preferred citable publication unless you specifically need to cite this preprint. Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromesObstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e. infection inflammation, thrombosis, endocrine disorder, immunologic rejection, genetic, and environmental), therefore, they may be regarded as syndromes. Placental vascular pathology and increased thrombin generation were reported in all of these obstetrical syndromes. Moreover, elevated concentrations of thrombin-antithrombin III complexes and changes in the coagulation as well as anticoagulation factors can be detected in the maternal circulation prior to the clinical development of the disease in some of these syndromes. In this review, we will assess the changes in the hemostatic system during normal and complicated pregnancy in maternal blood, maternal-fetal interface and amniotic fluid, and describe the contribution of thrombosis and vascular pathology to the development of the great obstetrical syndromes.PeerJ PrePrints | http://dx.doi.org/10.7287/peerj.preprints.487v1 | CC-BY 4.0 Open Access |

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“…and amniotic fluid 7,[20][21][22][23] . TFPI has been found in amniotic fluid as well 20 , but it is not clear if the presence of TF and its natural inhibitor is related to coagulation per se or is somehow connected with embryonic development 24 .…”

Section: What Are the Changes In The Coagulation System During Normalmentioning

confidence: 99%

“…During normal pregnancy, there is an increase in the amniotic fluid TF concentration 7,[20][21][22][23] . In Patients with a fetal demise had higher median amniotic fluid-TF concentration and activity than those with normal pregnancies.…”

Section: Hemostatic Changes In the Amniotic Fluid Of Women With Obstementioning

confidence: 99%

Peer Review #1 of "Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes (v0.1)"

2014

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Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes Obstetrical complications including preeclampsia, fetal growth restriction, preterm labor, preterm prelabor rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (i.e. infection inflammation, thrombosis, endocrine disorder, immunologic rejection, genetic, and environmental), therefore, they may be regarded as syndromes. Placental vascular pathology and increased thrombin generation were reported in all of these obstetrical syndromes. Moreover, elevated concentrations of thrombin-anti-thrombin III complexes and changes in the coagulation as well as anticoagulation factors can be detected in the maternal circulation prior to the clinical development of the disease in some of these syndromes. In this review, we will assess the changes in the hemostatic system during normal and complicated pregnancy in maternal blood, maternal-fetal interface and amniotic fluid, and describe the contribution of thrombosis and vascular pathology to the development of the great obstetrical syndromes.

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Thromboplastin Activity in Amniotic Fluid

Cited by 16 publications

References 14 publications

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes

Peer Review #1 of "Placental vascular pathology and increased thrombin generation as mechanisms of disease in obstetrical syndromes (v0.1)"

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