Thrombosis management and challenges in COVID-19 patients presenting with acute coronary syndromes

Kaddoura, Rasha; Salam, Amar M

doi:10.4103/heartviews.heartviews_143_20

Cited by 4 publications

(3 citation statements)

References 99 publications

(211 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pandemic has infected over 164 million people globally causing three million deaths by May 2021 ( 2 ). In addition, it has significantly increased hospitalization due to COVID-19 pneumonia with other organ disease ( 3 ). The disease has usually a self-limited course, ( 2 ) but moderate or severe symptoms were reported in approximately 20% of COVID-19 patients, with a progression rate to critical stages of 5% ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

COVID-19-associated hypertriglyceridemia and impact of treatment

Kaddoura,

Mohamed Ibrahim,

Al-Amri

et al. 2024

Front. Med.

Self Cite

View full text Add to dashboard Cite

BackgroundCoronavirus disease 2019 (COVID-19) associated hypertriglyceridemia was observed among patients admitted to intensive care units (ICU) in Qatar. This study aimed to describe COVID-19-associated-hypertriglyceridemia in ICU patients and the impact of treating hypertriglyceridemia on clinical outcomes.MethodsA retrospective observational cohort study of adult patients who were admitted to the ICU with a confirmed diagnosis of COVID-19 pneumonia according to the World Health Organization criteria. Hypertriglyceridemia was defined as triglyceride level of 1.7 mmol/L (≥150 mg/dL) and severe hypertriglyceridemia as fasting TG of ≥5.6 mmol/L (≥500 mg/dL).ResultsOf 1,234 enrolled patients, 1,016 (82.3%) had hypertriglyceridemia. Median age was 50 years and 87.9% were males. Patients with hypertriglyceridemia showed significantly longer time to COVID-19 recovery, ICU and hospital stay, and time to death (29.3 vs. 16.9 days) without a difference in mortality between groups. Of patients with hypertriglyceridemia, 343 (33.8%) received treatment (i.e., fibrate and/or omega-3). Patients in treatment group showed longer time to COVID-19 recovery and hospital stay with no difference in death rates in comparison with those in no-treatment group. Relatively older patients were less likely to experience hypertriglyceridemia (odd ratio (OR) 0.976; 95% CI: 0.956, 0.995) or to receive treatment (OR 0.977; 95% CI: 0.960, 0.994). Whereas patients who received tocilizumab were more likely to experience high TG level (OR 3.508; 95% CI: 2.046, 6.015) and to receive treatment for it (OR 2.528; 95% CI: 1.628, 3.926).ConclusionHypertriglyceridemia associated with COVID-19 did not increase death rate, but prolonged time to death and length of stay. Treating hypertriglyceridemia did not translate into improvement in clinical outcomes including mortality.

show abstract

Section: Introductionmentioning

confidence: 99%

COVID-19-associated hypertriglyceridemia and impact of treatment

Kaddoura,

Mohamed Ibrahim,

Al-Amri

et al. 2024

Front. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“… 8 Several studies and systematic reviews described the relationship between COVID‐19 and the increased risk of thrombosis. 9 , 10 , 11 It was found that thrombosis plays a major role in the morbidity and mortality of the disease. 9 , 10 , 11 In addition, multiple reports described an association between COVID‐19 and coronary artery thrombosis.…”

Section: Introductionmentioning

confidence: 99%

“… 9 , 10 , 11 It was found that thrombosis plays a major role in the morbidity and mortality of the disease. 9 , 10 , 11 In addition, multiple reports described an association between COVID‐19 and coronary artery thrombosis. 12 , 13 , 14 , 15 However, only few cases described simultaneous two‐coronary vessels acute thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Acute thrombotic occlusion involving three coronary arteries. A unique association withCOVID‐19 pneumonia

Habib

Abdelghani

Elyas

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical MessageRespiratory viruses, particularly COVID‐19, can be associated with severe cases of myocardial infarction (MI). Physicians should have a low threshold for MI in COVID‐19 patients who present with persistent chest pain as MI in rapidly deteriorating cases can be missed. Prompt response includes both timely diagnosis and swift treatment.AbstractThe coronavirus disease 2019 (COVID‐19) is associated with coronary artery thrombosis. Many cases of single‐vessel and few cases of two‐vessel thrombosis were reported. Herein, we report a unique association in a middle‐aged man diagnosed with COVID‐19 and presented later with acute myocardial infarction causing cardiogenic shock. The patient was found to have three‐vessel thrombosis.

show abstract

Severe COVID-19 post pregnancy complicated by acute thromboemboli resulting in ST-elevation myocardial infarction – A case report

Fu,

Park,

Rao

et al. 2024

Perfusion

View full text Add to dashboard Cite

Introduction: It has been shown that pregnancy can cause alterations in the severity of COVID-19 infection. We demonstrate an immediate post-partum patient diagnosed with severe COVID-19 and subsequently developed acute thrombosis of coronary artery. Case Summary: 35-year-old female unvaccinated for COVID-19 presented in labor and delivered on the same day. Several hours later, she was found to be in respiratory distress and tested positive for COVID-19. On day 7, computerized tomography (CT) of chest revealed bilateral pneumonia and pneumomediastinum. On day 8, she developed chest pain with electrocardiogram (EKG) showing inferior STelevations with troponin I of 0.6 ng/mL. She was intubated for airway protection and emergent diagnostic angiogram revealed thrombus occlusion of the third right posterolateral segment that resulted in thrombolysis in myocardial infarction (TIMI) 0 flow without evidence of underlying atherosclerotic disease in the remaining vessels. Intracoronary IIb/IIIa inhibitor was administered. Arterial blood gas in the lab revealed profound hypoxia despite being on 100% inspired oxygen. Multidisciplinary decision was made to cannulate patient for venovenous extracorporeal membrane oxygenation (ECMO) to treat severe COVID-19 pneumonia. She was finally decannulated from ECMO on day 65. After prolonged hospital stay, she eventually recovered and was discharged to rehabilitation. Conclusions: The center for disease control (CDC) surveillance has reported that pregnant patients with COVID-19 are more likely to require invasive ventilation and ECMO, and die given the immunological changes during pregnancy. Hypercoagulable state caused by combination of pregnancy and COVID-19 resulting in coronary thrombosis is rarely described in literature, our case demonstrated the paucity of this phenomenon.

show abstract

Thrombosis management and challenges in COVID-19 patients presenting with acute coronary syndromes

Cited by 4 publications

References 99 publications

COVID-19-associated hypertriglyceridemia and impact of treatment

COVID-19-associated hypertriglyceridemia and impact of treatment

Acute thrombotic occlusion involving three coronary arteries. A unique association withCOVID‐19 pneumonia

Severe COVID-19 post pregnancy complicated by acute thromboemboli resulting in ST-elevation myocardial infarction – A case report

Contact Info

Product

Resources

About