Through the amyloid gateway

George, Daniel R.; Whitehouse, Peter J.; D’Alton, Simon; Ballenger, Jesse F.

doi:10.1016/s0140-6736(12)62145-x

Cited by 8 publications

(4 citation statements)

References 2 publications

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“…With close to 2000 publications, Virchow has made major contributions to the field of cellular pathology and should be remembered for the introduction of certain medical terms that are still used today; Virchow defined the term “embolus” along with its thrombosis mechanism, the word “amyloid” and its reaction with iodine and sulphuric acid in the brain, and the term “granuloma.” 11 , 20 , 21 …”

Section: Virchow and His Aftermathmentioning

confidence: 99%

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18 F-DCFPyL Positron Emission Tomography Imaging

Werner

Andreé

Javadi

et al. 2018

Urology

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Section: Virchow and His Aftermathmentioning

confidence: 99%

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18 F-DCFPyL Positron Emission Tomography Imaging

Werner

Andreé

Javadi

et al. 2018

Urology

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“…In 1863, Rudolf Virchow observed an abnormal deposit reacting to starch indicators and named it “amyloid” after the Greek for starch . Although the moniker remained, further investigations revealed it to fundamentally be proteinaceous.…”

Section: Introductionmentioning

confidence: 99%

“…In 1863, Rudolf Virchow observed an abnormal deposit reacting to starch indicators and named it "amyloid" after the Greek for starch. 1 Although the moniker remained, further investigations revealed it to fundamentally be proteinaceous. All proteins appear able to misfold into amyloid then bind Congo red, exhibit birefringence, or exhibit a β X-ray diffraction pattern.…”

Section: Introductionmentioning

confidence: 99%

Primary cervical spine AL‐κ amyloidoma: A case report and review of the literature

et al. 2019

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Of the myriad of variants of amyloidoses where abnormally folded proteins damage native tissue, primary cervical spine amyloidoma represents one of the rarest forms. Since clinical presentations and imaging findings appear similar to other pathologies, including abscesses, metastatic lesions, and inflammatory lesions, a definitive diagnosis requires a biopsy with specific immunohistochemical stains. We present the first known case of primary cervical amyloid light‐chain (AL)‐κ subtype amyloidoma and compare the clinical presentations, imaging findings, treatment options, and immunohistochemical subtypes of primary, hemodialysis, and multiple myeloma cervical amyloidomas. Our case is of a 58‐year‐old man who developed neck pain radiating to the left arm with bilateral upper extremity weakness over several months. Magnetic resonance imaging revealed a circumferential C1–C2 mass extending into the neural foramina inducing severe mass effect. The patient underwent C2 laminectomy and resection of the lesion which was discovered during surgery to be completely epidural. Postoperatively, his pain and weakness improved. A complete work‐up was negative for systemic amyloidosis or inflammatory conditions. In the setting of a long clinical history of hemodialysis, this patient required specific staining and laboratory testing to correctly diagnose his primary cervical AL‐κ subtype amyloidoma. Cervical amyloidomas comprise a very small minority of amyloid pathology with an exceptional prognosis following successful surgical resection and stabilization. It is recommended these patients undergo surgical resection with appropriate characterization and a complete work‐up to rule out systemic disease.

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“…The term 'amyloid' was first coined by Virchow in 1863 due the material's similar staining characteristics to starch [12]. Today, amyloid is known for its association with chronic systemic illness and high mortality rate.…”

Section: Discussionmentioning

confidence: 99%