THU0073 Elastase and lactoferrin as indicators of functional activity of polymorphonuclear cells in rheumatoid arthritis

Abstract

NCBI). mRNA expression of distinct clones were confirmed by RT-PCR. Moreover, in situ hybridization showed that distinct genes, such as Fbx3 and S100A4, were also expressed on synovial tissues from patients with RA but not from non-RA patients, suggesting that these molecules may contribute to the pathogenesis of RA. Conclusion In this study, a number of molecules, including several novel genes, were isolated from RA-SF using suppression subtraction hybridization. The expression of these molecules may be involved in synovial activation in the pathogenesis of RA. *K. Masuda is supported by Japan Rheumatism Foundation.