Abstract:BackgroundEosinophilic granulomatosis with polyangiitis (EGPA) belongs to the group of ANCA associated vasculitides. While the combination of asthmatic symptoms and vasculitis characterize the disease clinically, eosinophilia and increased serum IgE concentrations are serologic hallmarks. The role of B lymphocytes in EGPA has not been defined so far, but therapeutic response to rituximab in EGPA points towards a role of B-cells in the pathogenesis of EGPA.ObjectivesTo characterize the peripheral B cell compart… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.