Thymic Atrophy Caused by Thymocyte Apoptosis in Experimental Severe Acute Pancreatitis

Takeyama, Yoshifumi; Nishikawa, Junsuke; Ueda, Takashi; Hori, Yoshiaki

doi:10.1006/jsre.1998.5360

Cited by 19 publications

(14 citation statements)

References 20 publications

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“…Firstly, we found that significant thymic atrophy occurred, due to thymocyte apoptosis, during experimental severe acute pancreatitis in rats. 43 Moreover, we clarified that peripheral lymphocyte numbers on admission were significantly lower in patients with subsequent infectious complications than in the patients without these complications, and we found that the reduction in lymphocytes from the peripheral circulation was due to apoptosis. 44 Although the ratio of apoptotic lymphocytes at collection did not differ between pancreatitis patients and normal subjects, the ratio increased significantly after 24-h incubation only in the lymphocytes collected from the pancreatitis patients.…”

Section: Apoptosis Of Lymphocytes and Lymphatic Tissuesmentioning

confidence: 92%

Significance of apoptotic cell death in systemic complications with severe acute pancreatitis

Takeyama

2005

J Gastroenterol

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In severe acute pancreatitis, multiple organ failure in the early stage after onset, and sepsis in the late stage, due to infection of pancreatic or peripancreatic devitalized tissue, contribute to its high mortality. In analogy with sepsis, evidence has accumulated of the significance of apoptotic cell death in the systemic manifestations associated with acute pancreatitis. Since we identified apoptosis-inducing activity in pancreatitis-associated ascitic fluid in 1995, a number of investigators, including our group, have reported, through animal experiments, that apoptosis occurred in the parenchymal cells constituting organs, such as alveolar epithelial cells in the lung, renal tubular cells in the kidney, and hepatocytes in the liver, and this apoptosis was involved in organ dysfunction with severe acute pancreatitis. Moreover, through clinical and experimental investigations, apoptosis has been revealed to be involved in the mechanism of infectious complications in acute pancreatitis. Namely, apoptosis in lymphatic tissues and peripherally circulating lymphocytes is involved in the impairment of cellular immunity, and apoptosis in gut epithelial cells is implicated in bacterial translocation. These results suggest that apoptotic cell death may play a considerable role in affecting mortality and morbidity in severe acute pancreatitis. Control of apoptosis could be a potent strategy for improvement of the clinical outcome in severe acute pancreatitis.

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Section: Apoptosis Of Lymphocytes and Lymphatic Tissuesmentioning

confidence: 92%

Significance of apoptotic cell death in systemic complications with severe acute pancreatitis

Takeyama

2005

J Gastroenterol

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“…On the other hand, we have reported that thymic atrophy and splenic atrophy occur in rat experimental severe acute pancreatitis 8,9 and that peripheral lymphocyte reduction due to apoptosis is linked to the development of subsequent infectious complications in patients with SAP. 10 In addition, we have demonstrated that the helper T cell type 1 (Th1)/Th2 balance tends to Th1 suppression in experimental SAP.…”

Section: Introductionmentioning

confidence: 94%

Immunosuppression in patients with severe acute pancreatitis

et al. 2006

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“…Particularly, Curley et al reported a significant decrease in the proportion of helper T cells in severe acute pancreatitis. 5 Moreover, we have reported that thymic atrophy and splenic atrophy occur in rat experimental severe acute pancreatitis 7,8 and that peripheral lymphocyte reduction due to apoptosis is linked to the development of subsequent infectious complications in patients with severe acute pancreatitis. 9,10 Recently, the concept of "Th1 (helper T cell type 1)/ Th2 (helper T cell type 2) balance" has been introduced for understanding the pathophysiological response during many diseases.…”

Section: Introductionmentioning

confidence: 98%

Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis

et al. 2006

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Thymic Atrophy Caused by Thymocyte Apoptosis in Experimental Severe Acute Pancreatitis

Cited by 19 publications

References 20 publications

Significance of apoptotic cell death in systemic complications with severe acute pancreatitis

Significance of apoptotic cell death in systemic complications with severe acute pancreatitis

Immunosuppression in patients with severe acute pancreatitis

Significant elevation of serum interleukin-18 levels in patients with acute pancreatitis

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