Thymic Epithelial Tumor with Heart Metastasis in a Horse

Shahriar, Farshid; Moore, Janet

doi:10.4061/2010/386378

Cited by 6 publications

(9 citation statements)

References 12 publications

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“…A predominant feature of this neoplasm and the findings in this reported case is the lack of neoplastic nature identified on histopathology, despite the aggressive behaviour of the tumour in the host. In the reported case, cardiac invasion was attributed to lymphatic drainage or direct local invasion, although haematogenous spread was also considered a possibility (Shahriar and Moore 2010).…”

Section: Primary Thoracic Tumoursmentioning

confidence: 97%

“…2001). The equine case report that utilised this classification scheme describes a type A tumour characterised by proliferation of spindle cells without nuclear atypia that contain no more than a few non‐neoplastic lymphocytes and inconspicuous nuclei (Shahriar and Moore 2010). Thymic tumours are rare in horses.…”

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

“…1986; Furuoka et al . 1987; Shahriar and Moore 2010). A mediastinal mass, associated lymphadenopathy and marked pericardial involvement was reported in one case (Furuoka et al .…”

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

“…A recent report describes an 18‐year‐old Tennessee Walking Horse which died suddenly while on a trail ride (Shahriar and Moore 2010). Post mortem examination revealed the pleural cavity and pericardial sac to contain a combined volume of 300–500 ml of serosanguineous fluid.…”

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

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Diagnostic challenges: Equine thoracic neoplasia

Davis

Rush

2011

Equine Veterinary Education

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SummaryThe diagnosis of thoracic neoplasia in the horse can be difficult due to the nonspecific nature of the clinical signs and their overlap with other pulmonary diseases. Haematological and serum biochemical evaluation, thoracic ultrasonography, radiography, endoscopic examination, and, where appropriate, thoracocentesis and pleural fluid cytology may all be helpful in reaching a diagnosis. Granular cell tumours are the most frequently reported primary pulmonary tumours of horses. They occur as single or multiple masses adjacent to bronchi and bronchioles, and the mass typically extends into the airway, resulting in partial or complete occlusion of the lumen. Thymic tumours are classified as benign or metastatic, based on evidence of tissue invasiveness, even though they uniformly appear benign histologically. These tumours are derived from epithelial reticular cells of the thymus and are rare in horses. Other primary thoracic neoplasms originate from various pulmonary tissues and are primarily reported as single case reports: pulmonary and bronchial carcinoma and adenocarcinoma, bronchogenic squamous cell carcinoma, bronchial myxoma, pulmonary chondrosarcoma, pulmonary leiomyosarcoma and pleuropulmonary blastoma. Clinical signs of these primary pulmonary neoplasms are dependent on the tumour type and location, but commonly include chronic cough, weight loss, anorexia, fever and respiratory difficulty; ventral oedema, pleural effusion and epistaxis are also frequently observed. Mesothelioma is a rare primary pleural tumour arising from the mesothelium of the pleura, pericardium and peritoneum. The clinical presentation in horses includes weight loss, respiratory difficulty and large volume pleural effusion. The tumour appears ultrasonographically as multiple small nodules on a thick serosal surface and pleural biopsy is diagnostic. Lymphoma is the most common haematopoietic neoplasm in horses, which can present with 4 main manifestations of lesions: mediastinal, multicentric, alimentary and cutaneous. Common clinical features include chronic weight loss, lethargy, anorexia, subcutaneous oedema, lymphadenopathy, colic, bleeding tendency and diarrhoea. Coughing and laboured respiratory effort are often apparent in individuals suffering from mediastinal masses. In such instances, pleural effusion may result in severe pulmonary atelectasis and pulmonary function is significantly compromised. Haemangiosarcoma is the second most common metastatic thoracic neoplasm in horses. Disseminated haemangiosarcoma is aggressive and rapidly progressive. The clinical presentation often includes tachypnoea, pale or icteric mucous membranes, respiratory distress, epistaxis, and subcutaneous, cutaneous or intramuscular masses. Other tumour types that metastasise to the thoracic cavity include adenocarcinoma, squamous cell carcinoma, fibrosarcoma, metastatic melanoma, mastocytoma and undifferentiated sarcoma. The clinical features of these tumours are generally nonspecific and often relate more to the primary site of tumour format...

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Section: Primary Thoracic Tumoursmentioning

confidence: 97%

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

“…1986; Furuoka et al . 1987; Shahriar and Moore 2010). A mediastinal mass, associated lymphadenopathy and marked pericardial involvement was reported in one case (Furuoka et al .…”

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

Section: Primary Thoracic Tumoursmentioning

confidence: 99%

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Diagnostic challenges: Equine thoracic neoplasia

Davis

Rush

2011

Equine Veterinary Education

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“…The literature suggests a predisposition in goats (Migaki 1969;Hadlow 1978). Only three individually published cases of thymoma exist in the horse to date (Whiteley et al 1986;Furuoka et al 1987;Shahriar and Moore 2010). Adult or aged animals are most often affected.…”

Section: Introductionmentioning

confidence: 99%

Atypical thymoma in a horse: Diagnostic approach and application of an alternative histological classification system

Pudert

Weyrich

Geburek

et al. 2020

Equine Veterinary Education

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Thymoma is a rare condition in horses. This case of a 24-yearold Warmblood gelding that was presented with oedema and signs of vascular congestion of the left forelimb caused by a thoracic mass is described. The diagnostic work-up included blood chemistry, cytology of pleural effusion, ultrasonography, radiography and the visualisation and collection of a tissue sample by thoracoscopy. Finally, postmortem findings and histopathology revealed thymic epithelial neoplasia with histomorphologic features previously unreported in horses. The unique mixture of spindle-shaped and epithelioid tumour cells in combination with clear features of malignancy suggested the application of the Moran and Suster histological classification system for thymomas in humans (Moran and Suster, 2008, Curr. Treat. Options Oncol., 9, 288), which has not been reported in an equine case before and fits well to the present case. A 24-year-old Warmblood gelding was presented with a 2week history of left forelimb swelling, intermittent lameness, pyrexia (38.5-39°C) and lethargy. Previous treatments for suspected cellulitis with bandaging, administration of 1 Contributed equally.

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Phenotypic variation of thymic epithelial cells and partial spontaneous regression in thymoma of a cow

Ohfuji¹

2017

Comp Clin Pathol

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Thymic Epithelial Tumor with Heart Metastasis in a Horse

Cited by 6 publications

References 12 publications

Diagnostic challenges: Equine thoracic neoplasia

Diagnostic challenges: Equine thoracic neoplasia

Atypical thymoma in a horse: Diagnostic approach and application of an alternative histological classification system

Phenotypic variation of thymic epithelial cells and partial spontaneous regression in thymoma of a cow

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