Thymic lipofibroadenomas: Three case reports

Yang, Mingyong; Wang, Zhiqiang; Chen, Liqian; Gao, Su-Mei; Fu, Xing-Ning; Zhang, Haining; Zhang, Kexin; Xu, Hao

doi:10.12998/wjcc.v11.i1.164

Cited by 2 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…[ 118,120 ] Several ROS generation mechanisms have been hypothesized and involve sonoluminescence, as well as sonophysicochemical effects. [ 121,122 ] Sonoluminescence is the process in which light is emitted by the excitation of gaseous species dissolved in solution through acoustic cavitation and the emitted light excites sonosensitizers, inducing the generation of ROS (including 1 O 2 and OH . ).…”

Section: External Stimuli‐responsive Nanomaterialsmentioning

confidence: 99%

“…[ 123–125 ] Sonophysicochemical effects involve the direct production of ROS from sonosensitizers by the high pressure and temperature created through the implosion of ultrasound‐produced cavitation gas bubbles following a thermal energy transfer mechanism. [ 122,126,127 ] Figure illustrates the chemical structure of a number of these compounds. [ 128 ]…”

Section: External Stimuli‐responsive Nanomaterialsmentioning

confidence: 99%

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Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Elsherbeny,

Bayraktutan,

et al. 2023

Advanced Therapeutics

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Pancreatic cancer is characterized by a high mortality rate and unfavorable prognosis. This is primarily attributed to poor accumulation of therapeutic agents at the target site due to the presence of a highly complex tumor microenvironment surrounding the pancreatic cancer tissue. However, a promising avenue for targeted drug delivery has emerged in the form of stimuli‐responsive materials. These advanced nanocarriers, encompassing both external and internal stimuli‐responsive nanoparticles, can be formulated to control the release of therapeutic agents precisely in response to specific activation. By harnessing external stimuli such as light, ultrasound, or magnetic fields, as well as intrinsic biological triggers including pH, redox potential, hypoxia, and temperature, these nanomaterials exhibit ‘intelligent’ and selective responses within complex biological environments. These responsive nanoparticles have been shown to address challenges associated with poor vascularity and thick desmoplastic stromal layers, which are hallmarks of pancreatic cancer, by promoting enhanced drug accumulation and release at the target site relative to conventional therapy. This work explores the design strategies for advanced stimuli‐responsive nanomaterials, integrating both internal and external stimuli, with the potential to enhance drug delivery efficacy in pancreatic cancer. It addresses the challenges and prospects in their development and offers insights for future clinical applications.

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Section: External Stimuli‐responsive Nanomaterialsmentioning

confidence: 99%

Section: External Stimuli‐responsive Nanomaterialsmentioning

confidence: 99%

Responsive Nanomaterial Delivery Systems for Pancreatic Cancer Management

Elsherbeny,

Bayraktutan,

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

show abstract

“…1 Sonodynamic therapy (SDT) generates reactive oxygen species (ROS) and induces cavitation effects by activating sonosensitizers via ultrasound (US) irradiation, which can cause apoptosis and necrosis, thereby killing tumor cells. 2,3 SDT demonstrates the potential for targeted therapy as it offers the ability to focus US on small tissue areas in the body. Therefore, SDT is considered a non-invasive, precise, safe, efficient, and repeatable treatment.…”

Section: Introductionmentioning

confidence: 99%