Thymine-functionalized amphiphilic biodegradable copolymers for high-efficiency loading and controlled release of methotrexate

Cheng, Dong‐Bing; Li, Youmei; Cheng, Yin‐Jia; Wu, Yan; Chang, Xiu-Peng; He, Feng; Zhuo, Ren‐Xi

doi:10.1016/j.colsurfb.2015.10.002

Cited by 13 publications

(16 citation statements)

References 40 publications

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“…Due to the possible dehydration of the polymer chains in dry state, the average diameters of copolymeric micelles on the TEM image were smaller than that measured by DLS. 35 Furthermore, the variation trends of P1−P5 particle size measured by TEM were in good agreement with the DLS results.…”

Section: ■ Results and Discussionsupporting

confidence: 79%

“…TEM observation (Figure ) showed the P3, P4, and P5 dispersed in spherical shape with average sizes of 46 ± 4, 30 ± 3, and 23 ± 3 nm, respectively. Due to the possible dehydration of the polymer chains in dry state, the average diameters of copolymeric micelles on the TEM image were smaller than that measured by DLS . Furthermore, the variation trends of P1–P5 particle size measured by TEM were in good agreement with the DLS results.…”

Section: Results and Discussionsupporting

confidence: 73%

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In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates

Cheng

Wang

et al. 2017

Biomacromolecules

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The stimuli-responsive polymeric nanocarriers have been studied extensively, and their structural changes in cells are important for the controlled intracellular drug release. The present work reported RGD-dextran/purpurin 18 conjugates with pH-responsive phenylboronate as spacer for monitoring the structural change of nanovehicles through ratiometric photoacoustic (PA) signal. Phenylboronic acid modified purpurin 18 (NPBA-P18) could attach onto the RGD-decorated dextran (RGD-Dex), and the resulting RGD-Dex/NPBA-P18 (RDNP) conjugates with different molar ratios of RGD-Dex and NPBA-P18 were prepared. When the moles of NPBA-P18 were equivalent to more than triple of RGD-Dex, the single-stranded RDNP conjugates could self-assemble into nanoparticles in aqueous solution due to the fairly strong hydrophobicity of NPBA-P18. The pH-responsive aggregations of NPBA-P18 were investigated by UV-vis, fluorescence, and circular dichroism spectra, as well as transmission electron microscope. Based on distinct PA signals between monomeric and aggregated state, ratiometric PA signal of I/I could be presented to trace the structural change progress. Compared with RDNP single chains, the nanoparticles exhibited effective cellular internalization through endocytosis pathway. Furthermore, the nanoparticles could form well-ordered aggregates responding to intracellular acidic environment, and the resulting structural change was also monitored by ratiometric PA signal. Therefore, the noninvasive PA approach could provide a deep insight into monitoring the intracellular structural change process of stimuli-responsive nanocarriers.

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Section: ■ Results and Discussionsupporting

confidence: 79%

Section: Results and Discussionsupporting

confidence: 73%

In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates

Cheng

Wang

et al. 2017

Biomacromolecules

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“…Another example of using a multitopic hydrogen-bonding polymer to bind a drug molecule was reported by He and co-workers [ 78 ]. A thymine-functionalized monomer was copolymerized with ethylene glycol to generate functional polymer micelles.…”

Section: Recognition Of Small Molecules By Polymer Materialsmentioning

confidence: 99%

Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

Hutchins¹

2018

R. Soc. open sci.

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The design, synthesis and property characterization of new functional materials has garnered interest in a variety of fields. Materials that are capable of recognizing and binding with small molecules have applications in sensing, sequestration, delivery and property modification. Specifically, recognition of pharmaceutical compounds is of interest in each of the aforementioned application areas. Numerous pharmaceutical compounds comprise functional groups that are capable of engaging in hydrogen-bonding interactions; thus, materials that are able to act as hydrogen-bond receptors are of significant interest for these applications. In this review, we highlight some crystalline and polymeric materials that recognize and engage in hydrogen-bonding interactions with pharmaceuticals or small biomolecules. Moreover, as pharmaceuticals often exhibit multiple hydrogen-bonding sites, many donor/acceptor molecules have been specifically designed to interact with the drug via such multiple-point hydrogen bonds. The formation of multiple hydrogen bonds not only increases the strength of the interaction but also affords unique hydrogen-bonded architectures.

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“…Nanomaterials as drug carriers can escape from the reticuloendothelial system (RES) and accumulate at tumor sites through targeting effect . Recently, our group focus on the transformable nanomaterials that show high accumulation and retention in targeted sites because of assembly/aggregation induced retention (AIR) effect of peptide nanofibers (NFs) .…”

Section: Methodsmentioning

confidence: 99%

Site‐Specific Construction of Long‐Term Drug Depot for Suppression of Tumor Recurrence

Cheng

Zhang

Gao

et al. 2019

Small

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Local tumor recurrence after surgical resection is a critical concern in cancer therapy, and the current treatments, such as postsurgical chemotherapy, still show undesired side effects. Here a nonimplant strategy (transformation induced localization, TIL) is presented to in situ construct long‐term retentive drug depots, wherein the sustained drug release from fibrous drug depots results in highly efficient suppression of postsurgical local tumor relapse. The peptide‐based prodrug nanoparticles show favorable tumor targeting and instantly reorganize into fibrous nanostructures under overexpressed enzyme, realizing the construction of long‐term drug depot in the tumor site. After the resection surgery, the remnant cancer cells are still inhibited by the sustained drug release from the fibrous prodrug depot, effectively preventing postsurgical local recurrences. This TIL strategy shows great potential in cancer recurrence therapy and offers a novel perspective for constructing functional biomaterials in vivo.

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Thymine-functionalized amphiphilic biodegradable copolymers for high-efficiency loading and controlled release of methotrexate

Cited by 13 publications

References 40 publications

In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates

In Situ Monitoring Intracellular Structural Change of Nanovehicles through Photoacoustic Signals Based on Phenylboronate-Linked RGD-Dextran/Purpurin 18 Conjugates

Functional materials based on molecules with hydrogen-bonding ability: applications to drug co-crystals and polymer complexes

Site‐Specific Construction of Long‐Term Drug Depot for Suppression of Tumor Recurrence

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