Thymol has anticancer effects in U-87 human malignant glioblastoma cells

Seraj, Farid Qoorchi Moheb; Heravi-Faz, Niloofar; Soltani, Arash; Ahmadi, Seyed Sajad; shahbeiki, Fatemeh; Talebpour, Amir; Afshari, Amir R.; Ferns, Gordon A.; Bahrami, Afsane

doi:10.1007/s11033-022-07867-3

Cited by 19 publications

(7 citation statements)

References 48 publications

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“…A recent study utilizing U87 human malignant glioblastoma cells has shown that thymol induces apoptosis, increases Reactive Oxygen Species (ROS), and increases levels of the proapoptotic factors Bax and p53 [ 22 ]. Similar proapoptotic effects were observed in bladder cancer cells by activating the apoptotic intrinsic pathway via caspase-3, caspase-9, release of cytochrome c, and reduction of the antiapoptotic protein bcl-2 [ 23 ].…”

Section: Thymolmentioning

confidence: 99%

Anti-Inflammatory and Antimicrobial Properties of Thyme Oil and Its Main Constituents

Vassiliou

Awoleye

Davis

et al. 2023

IJMS

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Thyme oil (TO) is derived from the flowers of various plants belonging to the genus Thymus. It has been used as a therapeutic agent since ancient times. Thymus comprises numerous molecular species exhibiting diverse therapeutic properties that are dependent on their biologically active concentrations in the extracted oil. It is therefore not surprising that oils extracted from different thyme plants present different therapeutic properties. Furthermore, the phenophase of the same plant species has been shown to yield different anti-inflammatory properties. Given the proven efficacy of TO and the diversity of its constituents, a better understanding of the interactions of the various components is warranted. The aim of this review is to gather the latest research findings regarding TO and its components with respect to their immunomodulatory properties. An optimization of the various components has the potential to yield more effective thyme formulations with increased potency.

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Section: Thymolmentioning

confidence: 99%

Anti-Inflammatory and Antimicrobial Properties of Thyme Oil and Its Main Constituents

Vassiliou

Awoleye

Davis

et al. 2023

IJMS

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“…Additionally, thymol has also been recognized as anti-tumor agent, which is demonstrated in a recent study during the evaluation of the cell viability and apoptosis in U-87 cells treated with thymol at different concentrations. The half-maximal inhibitory concentration (IC 50 ) of thymol in the U-87 cells was 230 μM, while on a normal cell line it did not exhibit any cytotoxic effect at the same concentration [ 57 ]. Besides the two biologically active phytoconstituents, α-pinene and thymol, another major constituent, 8,11-octadecadienoic acid, as the methyl ester found in M.E.…”

Section: Resultsmentioning

confidence: 99%

Diversity of Citrullus colocynthis (L.) Schrad Seeds Extracts: Detailed Chemical Profiling and Evaluation of Their Medicinal Properties

Khan

Al-hamoud

et al. 2023

Plants

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Seeds and fruits of Citrullus colocynthis have been reported to possess huge potential for the development of phytopharmaceuticals with a wide range of biological activities. Thus, in the current study, we are reporting the potential antimicrobial and anticancer properties of C. colocynthis seeds extracted with solvents of different polarities, including methanol (M.E.), hexane (H.E.), and chloroform (C.E.). Antimicrobial properties of C. colocynthis seeds extracts were evaluated on Gram-positive and Gram-negative bacteria, whereas, anticancer properties were tested on four different cell lines, including HepG2, DU145, Hela, and A549. All the extracts have demonstrated noteworthy antimicrobial activities with a minimum inhibitory concentration (MIC) ranging from 0.9–62.5 µg/mL against Klebsiella planticola and Staphylococcus aureus; meanwhile, they were found to be moderately active (MIC 62.5–250 µg/mL) against Escherichia coli and Micrococcus luteus strains. Hexane extracts have demonstrated the highest antimicrobial activity against K. planticola with an MIC value of 0.9 µg/mL, equivalent to that of the standard drug ciprofloxacin used as positive control in this study. For anticancer activity, all the extracts of C. colocynthis seeds were found to be active against all the tested cell lines (IC50 48.49–197.96 µg/mL) except for the chloroform extracts, which were found to be inactive against the HepG2 cell line. The hexane extract was found to possess the most prominent anticancer activity when compared to other extracts and has demonstrated the highest anticancer activity against the DU145 cell line with an IC50 value of 48.49 µg/mL. Furthermore, a detailed phytoconstituents analysis of all the extracts of C. colocynthis seeds were performed using GC–MS and GC–FID techniques. Altogether, 43 phytoconstituents were identified from the extracts of C. colocynthis seeds, among which 21, 12, and 16 components were identified from the H.E., C.E., and M.E. extracts, respectively. Monoterpenes (40.4%) and oxygenated monoterpenes (41.1%) were the most dominating chemical class of compounds from the hexane and chloroform extracts, respectively; whereas, in the methanolic extract, oxygenated aliphatic hydrocarbons (77.2%) were found to be the most dominating chemical class of compounds. To the best of our knowledge, all the phytoconstituents identified in this study are being reported for the first time from the C. colocynthis.

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“…ROS is known as one of the main upstream effectors in the regulation of apoptosis and excess cellular levels of ROS cause damage to cellular components, which can result in cell death [ 37 ]. Mitochondria plays an important role in tumorigenesis and apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Antiglioma Natural Products from the Marine-Associated Fungus Penicillium sp. ZZ1750

Yong

Kaleem

et al. 2022

Molecules

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Marine-derived Penicillium fungi are one of the most important sources for the discovery of new bioactive natural products. This study characterized the isolation, structures, and antiglioma activities of twelve compounds, including three novel ones— penipyridinone B (1), 11S-(–)-penilloid A (2), and 11R,14E-(+)-penilloid A (3)—from the marine fungus Penicillium sp. ZZ1750. The structures of the novel compounds were determined via extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, Mosher¢s method, optical rotation (OR) calculations, and electronic circular dichroism (ECD) calculations. Penipyridinone B represents the first example of its structural type and showed potent antiglioma activity, with IC50 values of 2.45 mM for U87MG cells and 11.40 mM for U251 cells. The known compounds of questiomycin A (9) and xanthocillin X (10) also showed antiproliferative activity against both U87MG and U251 cells, with IC50 values of 13.65 mM to 22.56 mM. The antiglioma activity of questiomycin A and xanthocillin X may be related to the promotion of reactive oxygen species (ROS) production, the reduction of mitochondrial membrane potential (MMP), and the enhancement of caspase-3 enzyme activity.

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Thymol has anticancer effects in U-87 human malignant glioblastoma cells

Cited by 19 publications

References 48 publications

Anti-Inflammatory and Antimicrobial Properties of Thyme Oil and Its Main Constituents

Anti-Inflammatory and Antimicrobial Properties of Thyme Oil and Its Main Constituents

Diversity of Citrullus colocynthis (L.) Schrad Seeds Extracts: Detailed Chemical Profiling and Evaluation of Their Medicinal Properties

Antiglioma Natural Products from the Marine-Associated Fungus Penicillium sp. ZZ1750

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