Thymoquinone and its therapeutic potentials

Darakhshan, Sara; Pour, Ali Bidmeshki; Colagar, Abasalt Hosseinzadeh; Sisakhtnezhad, Sajjad

doi:10.1016/j.phrs.2015.03.011

Cited by 420 publications

(390 citation statements)

References 182 publications

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“…So the heat generated during the extraction of SPO (~50 °C) can cause melting of the crystals of this compound and facilitate its co-extraction with the crude oil leading to a higher percentage in the volatile fraction of SPO. One should bear in mind that TQ is the compound that gives the volatile oil and consequently its parent crude oil their functionality due to the pharmaceutical and therapeutic properties of this compound (Gülşen et al, 2016;Darakhshan et al, 2015;Schneider-Stock et al, 2014). From the above mentioned, it could be presumed that the high yield of the volatile oil fraction (2.6%) along with its high content of TQ (68.13%) of the SPO can be considered contributing factors that justify the high oxidative stability and relatively lower PV of that oil, as mentioned in the previous sections.…”

Section: Discussionmentioning

confidence: 99%

Potentials of enhancing the physicochemical and functional characteristics of <em>Nigella sativa</em> oil by using the screw pressing technique for extraction

Hamed¹,

Shaaban²,

Ramadan³

et al. 2017

Grasas y Aceites

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SUMMARY:In the current investigation the crude oil of Nigella sativa was extracted from seeds using hydraulic and screw pressing techniques. Different parameters were evaluated in order to find out the appropriate technique to enhance the physicochemical and functional-related characteristics of the extracted crude oil. Results showed that the acid and peroxide values were significantly lower in the screw pressed oil (SPO) than in the hydraulic pressed oil (HPO). The total phenolic content of the SPO was significantly higher than that of HPO. Evaluation of the oxidative stability using the Rancimat test showed that SPO recorded a much higher oxidative stability index (40.07 h) than HPO (0.51 h). The yield of the volatile oil fraction and its contents of thymoquinone isolated from the SPO were higher than that from the HPO. Biological evaluation revealed that the SPO had significantly higher antimicrobial activity than HPO against Listeria monocytogenes and Staphylococcus aureus at 40 µL/well. KEYWORDS : Crude oil; Functionality; Hydraulic pressing; Nigella sativa; Screw pressing RESUMEN: Mejoras potenciales de las características físico-químicas y funcionales del aceite de Nigella sativa mediante extracción con prensa de tornillo. En la presente investigación se extrajo el aceite crudo de Nigella sativa de las semillas utilizando técnicas hidráulicas y de prensado de tornillo. Se evaluaron diferentes parámetros para conocer la técnica apropiada que potencie las características fisicoquímicas y funcionales del aceite extraído. Los resultados mostraron que los valores de ácido y peróxido fueron significativamente más bajos en el aceite de presión con tornillo (SPO) que en el aceite prensado hidráulico (HPO). El contenido fenólico total del SPO fue significativamente mayor que el de HPO. La evaluación de la estabilidad oxidativa mediante Rancimat demostró que el aceite SPO tiene un índice de estabilidad oxidativa mucho más alto (40,07 h) que el HPO (0,51 h). El rendimiento de la fracción volátil y su contenido de timoquinona aislada del aceite SPO fueron superiores a los del HPO. La evaluación biológica reveló que el aceite SPO tenía una actividad antimicrobiana significativamente mayor que el HPO contra Listeria monocitogenes y Staphylococcus aureus a 40 μL/pocillo.

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Section: Discussionmentioning

confidence: 99%

Potentials of enhancing the physicochemical and functional characteristics of <em>Nigella sativa</em> oil by using the screw pressing technique for extraction

Hamed¹,

Shaaban²,

Ramadan³

et al. 2017

Grasas y Aceites

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“…TQ has relatively low toxicity as it is a well-tolerated agent in rodents (19). TQ exhibits its anticancer activity by modulating various molecular targets including activation of several caspases, induction of ROS generation, and cell signaling STAT3 (18,20). Several studies explained the anticancer effects of TQ attributed to the induction of PPAR-γ (peroxisome proliferator-activated receptor gamma), PTEN (phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase) expression, as well as p53-dependent and independent apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Thymoquinone on IL-6 Gene Expression and Some Cellular Signaling Pathways in Prostate Cancer PC3 Cells

Ranjbari

Heidarian

Ghatreh‐Samani

2017

Jundishapur J Nat Pharm Prod

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“…According to Hariharan et al [11], thymoquinone (TQ) the well-known NS component has shown antimethicillin-resistant activity in S. aureus. TQ is also evident to act against a number of gram positive and gram negative pathogenic bacteria [8].…”

Section: Ns Against Bacteriamentioning

confidence: 99%

“…To date (March 2016) in the databases such as PubMed/Medline, Science Direct, Web of Science, Scopus, and google, a total of 1290 published evidences were found on the following topics: morphology of the plant, isolated compounds and their derivatives, and pharmacological activities. One general revision of this plant was done by Ahmad et al [2], following to a dermatological revision by Aljabre et al [3], an immunomodulatory and anti-inflammatory revision by Majdalawieh and Fayyad [4], an anti-inflammatory, antioxidant, an immunomodulatory [5], male fertility [6], metabolic parameters in diabetes mellitus [7], and thymoquinone and its therapeutic potentials by Darakhshan et al [8]. This review summarizes the above mentioned studies.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Islam¹

2016

Adv. Biomed. Pharma.

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Nigella sativa L. (NS) has a number of important biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anti-viral, anti-parasitic and anti-protozoal, cytotoxic, anticancer, neuro-, gastro-, cardio-, hetapto-and nephroprotective activities. In addition, the NS exerts beneficiary effects on reproductive, pulmonary and immune systems as well as in diabetes mellitus (DM), fertility (male and female), breast cancer, dermatological complications, dehydration, dyspepsia, and osmotic balance and so on. Among the isolated constituents, thymoquinone (TQ) is a vastly studied phytochemical in NS. A number of reports suggest that, the NS may be one of the potential herbs in health promotion. This review paper will discuss the detailed and mechanistic aspects of the biological activity of N. sativa along with the reported phytoconstituents.

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Thymoquinone and its therapeutic potentials

Cited by 420 publications

References 182 publications

Potentials of enhancing the physicochemical and functional characteristics of <em>Nigella sativa</em> oil by using the screw pressing technique for extraction

Potentials of enhancing the physicochemical and functional characteristics of <em>Nigella sativa</em> oil by using the screw pressing technique for extraction

Effects of Thymoquinone on IL-6 Gene Expression and Some Cellular Signaling Pathways in Prostate Cancer PC3 Cells

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

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