Thymoquinone improves experimental autoimmune encephalomyelitis by regulating both pro-inflammatory and anti-inflammatory cytokines

Kazemi, Roya; Yazdanpanah, Esmaeil; Esmaeili, Seyed-Alireza; Yousefi, Bahman; Baharlou, Rasoul; Haghmorad, Dariush

doi:10.1007/s11033-023-09148-z

Mol Biol Rep

2024

DOI: 10.1007/s11033-023-09148-z

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Thymoquinone improves experimental autoimmune encephalomyelitis by regulating both pro-inflammatory and anti-inflammatory cytokines

Roya Kazemi,

Esmaeil Yazdanpanah,

Seyed-Alireza Esmaeili

et al.

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2024

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Cited by 2 publications

References 45 publications

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Exploring the immune‐modulating properties of boswellic acid in experimental autoimmune encephalomyelitis

Shadab,

Abbasi‐Kolli,

Yazdanpanah

et al. 2024

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Multiple sclerosis (MS) is a condition where the central nervous system loses its myelin coating due to autoimmune inflammation. The experimental autoimmune encephalomyelitis (EAE) simulates some aspects of human MS. Boswellic acids are natural compounds derived from frankincense extract, known for their anti‐inflammatory properties. The purpose of this research was to investigate therapeutic potential of boswellic acids. Mice were divided into three groups: low‐dose (LD), high‐dose (HD), and control groups (CTRL). Following EAE induction, the mice received daily doses of boswellic acid for 25 days. Brain tissue damage, clinical symptoms, and levels of TGF‐β, IFN‐γ, and IL‐17 cytokines in cell cultured supernatant of lymphocytes were assessed. Gene expression of transcription factors in brain was measured using real‐time PCR. The levels of brain demyelination were significantly lower in the treatment groups compared to the CTRL group. Boswellic acid reduced the severity and duration of EAE symptoms. Furthermore, boswellic acid decreased the amounts of IFN‐γ and IL‐17, also the expression of T‐bet and ROR‐γt in brain. On the contrary, it increased the levels of TGF‐β and the expression FoxP3 and GATA3. Our findings suggest that boswellic acids possess therapeutic potential for EAE by modulating the immune response and reducing inflammation.

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Exploring the immune‐modulating properties of boswellic acid in experimental autoimmune encephalomyelitis

Shadab,

Abbasi‐Kolli,

Yazdanpanah

et al. 2024

APMIS

Self Cite

View full text Add to dashboard Cite

show abstract

Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice

Shojaedini,

Hemadi,

Saki

et al. 2024

Jentashapir J Cell Mol Biol

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Background: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P < 0.01), and reduced LC3-II levels (P < 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice.

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Thymoquinone improves experimental autoimmune encephalomyelitis by regulating both pro-inflammatory and anti-inflammatory cytokines

Cited by 2 publications

References 45 publications

Exploring the immune‐modulating properties of boswellic acid in experimental autoimmune encephalomyelitis

Exploring the immune‐modulating properties of boswellic acid in experimental autoimmune encephalomyelitis

Thymoquinone Effects on the Expression of p62 Gene in Cisplatin-Induced Testicular Damage in Mice

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