Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer

Kabil, Nashwa; Bayraktar, Recep; Kahraman, Nermin; Mokhlis, Hamada A.; Calin, George A.; López-Berestein, Gabriel; Özpolat, Bülent

doi:10.1007/s10549-018-4847-2

Cited by 70 publications

(63 citation statements)

References 50 publications

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“…Cell survival depends on the balance between cell proliferation and apoptosis. TQ has been found to inhibit the survival of many cancer cells derived from breast cancers [ 65 , 67 , 77 , 83 ], pancreatic cancer [ 84 ], gastric cancer [ 85 ], primary effusion lymphoma [ 43 ], prostate cancer [ 86 , 87 ], kidney cancer [ 88 ], squamous cell carcinoma [ 89 ], renal cell carcinoma [ 90 ], and cholangiocarcinoma [ 63 ], primarily through attenuation of the activity of AKT, a crucial kinase associated with cell survival. TQ inhibits the activation of AKT through ROS-dependent mechanisms and/or through activation of the lipid phosphatase, phosphatase and tensin homolog (PTEN).…”

Section: Tq-mediated Inhibition Of Cancer Cell Survivalmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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Section: Tq-mediated Inhibition Of Cancer Cell Survivalmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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“…In cancer, it is deemed therapeutic through its interference with cell proliferation, apoptosis, cell invasion, and metastasis in cancer cells using different in vitro and in vivo models. [6][7][8][9] Theses anticancer effects were reported in various types of cancers such as breast cancer cells, 10 colon cancer, 11 lung cancer, 12 cervical squamous carcinoma, 13 ovarian cancer, 14 prostate cancer cell, 15 and osteosarcoma. 16 In addition, synergistic therapeutic effects were elicited when TQ was given in combination with other chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 97%

<p>Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells</p>

Ibrahim

Rosli

Doolaanea

2020

IJN

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Introduction: Thymoquinone (TQ) is the main active compound extracted from Nigella sativa a traditional herb with wide therapeutic applications and recognizable anticancer properties. This study aimed to formulate and characterize TQ-nanoparticles using PLGA as a biocompatible coating material (TQ-PLGA NPs) with the evaluation of its therapeutic properties in human melanoma cancer cells. Methods: The TQ-PLGA NPs were prepared and characterized for size, zeta potential, encapsulation efficiency, and release profile. Results: The particle size was 147.2 nm, with 22.1 positive zeta potential and 96.8% encapsulation efficiency. The NPs released 45.6% of the encapsulated TQ within 3 h followed by characteristic sustained release over 7 days with a total of 69.7% cumulative release. TQ-PLGA NPs were taken up effectively by the cells in a time-dependent manner up to 24 h. Higher cell toxicity was determined within the first 24 h in melanoma cells due to the rapid release of TQ from the NPs and its low stability in the cell culture media. Conclusion: TQ-PLGA NPs is a potential anticancer agent taking advantage of the sustained release and tailored size that allows accumulation in the cancer tissue by the enhanced permeability and retention effect. However, stability problems of the active ingredient were address in this study and requires further investigation.

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“…Black cumin seed ( Nigella sativa ) and thymoquinone exercised a protective effect as they reduced the breast carcinogens and decreased the gene expressions of Id-1, Brac2, Bra1 and p53 mutations [ 249 ]. In another study, in vivo administration of thymoquinone (20 and 100 mg/kg) significantly decreased the progression of MDA-MB-231 tumors and inhibited the eukaryotic elongation factor 2 kinase (eEF-2K) in an orthotopic tumor mouse model of triple-negative breast cancer [ 250 ].…”

Section: Black Cumin ( Nigella Sativa )mentioning

confidence: 99%

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

et al. 2020

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Background: Breast cancer is one of the principal causes of death among women and there is a pressing need to develop novel and effective anti-cancer agents. Natural plant products have shown promising results as anti-cancer agents. Their effectiveness is reported as decreased toxicity in usage, along with safety and less recurrent resistances compared with hormonal targeting anti-cancer agents. Methods: A literature search was conducted for all English-language literature published prior to June 2020. The search was conducted using electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library. The search strategy included keywords such as breast cancer, herbs, anti-cancer biologically active components, clinical research, chemotherapy drugs amongst others. Results: The literature provides documented evidence of the chemo-preventative and chemotherapeutic properties of Ginseng, garlic (Allium sativum), Black cohosh (Actaea racemose), Tumeric (Curcuma longa), Camellia sinenis (green tea), Echinacea, Arctium (burdock), Flaxseed (Linum usitatissimum) and Black Cumin (Nigella sativa). Conclusions: The nine herbs displayed anti-cancer properties and their outcomes and mechanisms of action include inhibition of cell proliferation, angiogenesis and apoptosis as well as modulation of key intracellular pathways. However, more clinical trials and cohort human studies should be conducted to provide key evidence of their medical benefits.

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Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer

Cited by 70 publications

References 50 publications

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

<p>Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells</p>

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

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