Thymus abnormalities in ulcerative colitis —comparative study with other autoimmune diseases

Mizuno, Yoshio; Shimabukuro, K; Kurita, K.; Tsuchiya, Masaharu

doi:10.1007/bf02777706

Cited by 11 publications

(1 citation statement)

References 9 publications

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“…Cellmediated, organ-specific hypersensitivity reactions may accordingly be involved in the pathogenesis of ulcerative colitis. Tsuchiya et al (24), Yoshida (26), and Mizuno et al (18) reported that thymic lymphoid follicles were demonstrated in …”

Section: Discussionmentioning

confidence: 99%

HLA Antigens and Ulcerative Colitis in Japan

Tsuchiya¹,

Yoshida²,

Asakura³

et al. 1977

Digestion

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The HLA antigens in 44 cases of ulcerative colitis and 271 control individuals in Japan were studied. The NIH tissue typing method was used according to the new leukocyte nomenclature adapted by the WHO Committee. In normal Japanese populations, the HLA antigens, which were of high frequency, were HLA A2 (37.3 %), A9 (60.9 %) and B5 (40.6 %). On the contrary, the significantly high frequency of HLA B5 was demonstrated in ulcerative colitis, compared with that in control. Moreover, HLA B5 in cases with ulcerative colitis excluding those with proctitis only, was found with higher frequency than that in total cases. Although the most frequent haplotype was HLA A9-B5 in control, so frequent haplotype was not found in ulcerative colitis. A family study revealed no significant diathesis on the haplotype of HLA in ulcerative colitis. The relationship between MLC locus and ulcerative colitis was not yet clarified from the study of one family whose two members suffered from ulcerative colitis.

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Section: Discussionmentioning

confidence: 99%

HLA Antigens and Ulcerative Colitis in Japan

Tsuchiya¹,

Yoshida²,

Asakura³

et al. 1977

Digestion

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RNA tumor virus in human thymomas and thymus hyperplasias

Ono

Saito

Kondo

et al. 1985

Seminars in Surgical Oncology

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Human thymomas and thymus hyperplasias were examined for retroviruses. Most of these patients were complicated by systemic immunological diseases such as myasthenia gravis and pure red cell aplasia. The thymus cells were co-cultured with allogenic B cells or peripheral blood lymphocytes (PBL) pretreated with mitomycin C. Retrovirus-like particles were demonstrated in cultured thymus cells in all cases of thymomas and thymus hyperplasias examined by electron microscopy. In most cases, these particles were detected in thymus epithelial cells. Reverse transcriptase activity sedimenting at a density of 1.15-1.17 gm/cm3 in sucrose density gradients was eluted in the culture fluids. Retrovirus-like particles were demonstrated in human T cells infected with these particles. Antibodies to virus-infected T cells were detected in sera of the patients with thymoma and thymus hyperplasia. These results suggest that in thymomas and thymus hyperplasias, retroviruses that can be induced, following a proliferative stimulus, may be involved in the genesis of thymic disorders and in the pathogenesis of systemic immunological diseases.

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Other Conditions Associated with Thymic Disorders

Ruchti¹,

Hess²

1990

Surgery of the Thymus

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Thymus abnormalities in ulcerative colitis —comparative study with other autoimmune diseases

Cited by 11 publications

References 9 publications

HLA Antigens and Ulcerative Colitis in Japan

HLA Antigens and Ulcerative Colitis in Japan

RNA tumor virus in human thymomas and thymus hyperplasias

Other Conditions Associated with Thymic Disorders

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