Thymus stimulation and cancer prophylaxis byViscum proteins

Nienhaus, J.; Stoll, M.; Vester, F.

doi:10.1007/bf01898487

Cited by 22 publications

(5 citation statements)

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“…Despite data form literature showing a two-fold increase in the weight of the thymus due to the proliferation of cortical thymocytes in adult rats, the present data failed to nd any differences in the weight of prenatal thymus [59,72,73]. Theses ndings suggest that during the prenatal development of the thymus, the effect of VA on the proliferative response of thymocytes was not signi cant.…”

Section: Discussioncontrasting

confidence: 99%

“…Theses ndings suggest that during the prenatal development of the thymus, the effect of VA on the proliferative response of thymocytes was not signi cant. Nevertheless, the two-fold increase in the population of NK cells with the therapeutic dose (23.1% compared to 7.1-12.5% in the other groups) is in agreement with data in the literature [59,72,73]. The lack of statistically signi cance results was due to the few CD57-positive cells, which may be related to the reduced differentiation rate in this phase of development.…”

Section: Discussionsupporting

confidence: 91%

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The Safety of Viscum Album L. in A Murine Model: A Reproductive Toxicity Study

Ghelman¹,

Cernach²,

Ishigai³

et al. 2020

Preprint

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Abstract Background: The use of antineoplasic drugs in pregnancy poses a huge safety challenge because of the risk of teratogenicity, mutagenicity and carcinogenicity. The rational use of the herbal medicine Viscum album (VA) has shown promising results in several tumor lines as part of the strategy of immunotherapy and anti-angiogenesis in integrative oncology. The safety of intrauterine fetal exposure to VA is however unknown and can be further evidenced for therapeutic doses in pregnant cancer patients.Methods: 47 pregnant Wistar rats and 399 fetuses bred following exposure to VA were investigated. The rats were randomized into five groups. Control group (CG) received no treatment and stress group (SG) received daily vehicle subcutaneous injections alone in same volume as the treatment groups from day zero until the twentieth day of pregnancy. There were three treatments groups: therapeutic dose group (TG) received the usual therapeutic dose (UTD) of 0.013 mg/kg BW; high dose group (HG) received 12.5 mg/kg BW and very high dose group (VHG) received 25mg/kg BW, daily.Results: Weight gain was greater in the rats, placentas and fetuses in the TG and HG compared to SG. Histology of the placentas showed a greater inflammatory process in HG and VHG.Conclusion: Since no cases of abortion, embryotoxicity, natimortality or teratogenicity were found in the fetuses and histology detected no lesions in the tissues evaluated, it is reasonable to conclude that this drug is safe for use in pregnant rats.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

The Safety of Viscum Album L. in A Murine Model: A Reproductive Toxicity Study

Ghelman¹,

Cernach²,

Ishigai³

et al. 2020

Preprint

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“…MATHE et al showed that a polysaccharide fraction caused neutrophilia in mice [6]. Protein fractions induced splenomegaly and thymus hyperplasia in tumour bearing mice [7] and moreover inhibited tumour growth [8,9]. In vitro the proteins inhibited DNA synthesis of several tumour cell lines but did not affect bone marrow cells and splenocytes and even stimulated DNA synthesis of rat thymocytes [10].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Humoral and Cellular Immunity by Viscum Preparations

Bloksma¹,

Schmiermann²,

Reuver³

et al. 1982

Planta Med

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The immuno-adjuvanticity of fresh plant juice of Viscum album and a polysaccharide fraction isolated from the berries was studied. Both delayed hypersensitivity and antibody formation against sheep red blood cells (SRBC) were enhanced after immunization of mice with a mixture of antigen and plant juice. Polysaccharide stimulated the immune response when administered 5 minutes before the antigen. Adjuvant-active doses of plant juice but not of polysaccharide caused non-specific inflammation as measured by paw swelling. Polysaccharide inhibited the pinocytic activity of the mononuclear phagocytic system initially but stimulated later on. Plant juice stimulated only for a short time. Both preparations caused splenomegaly while polysaccharide also increased the weight of the liver. The effects are compared with the activity of the Viscum preparation IscadorR.

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“…8] and Evans and Prccce [8] used crude extracts of mistletoe (or Iscador) and reported a 40 50% inhibition in the growth of this tumor. Later work by Nienhaus et al [29] showed that prophylactic subcutaneous treatment of mice with viscum proteins caused stimulation of thymocytes of the treated mice and in these animals, the growth of transplanted tumor (SI80) was in hibited. In CCNSC screening, mistletoe extract caused significant inhibition of the growth of KB cells in culture.…”

Section: Animal Model Studiesmentioning

confidence: 99%

Recent Studies on the Anticancer Activities of Mistletoe <i>(Viscum album) </i>and Its Alkaloids

Khwaja

Dias

Pentecost³

1986

Oncology

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Detailed methods for in vitro/in vivo evaluation of anticancer drugs, with special reference to mistletoe extracts, have been reviewed. Mistletoe extracts have been shown to possess significant antitumor activity, in vivo, against murine tumors, Lewis lung carcinoma, colon adenocarcinoma 38 and C3H mammary adenocarcinoma 16/C. Methods for the extraction of biologically active alkaloids from mistletoe and their anticancer activities are presented. The possible origin of alkaloids in mistletoe plants, and their contributions towards a mechanism of anticancer activities of mistletoe axtracts, are proposed.

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Thymus stimulation and cancer prophylaxis byViscum proteins

Cited by 22 publications

References 0 publications

The Safety of Viscum Album L. in A Murine Model: A Reproductive Toxicity Study

The Safety of Viscum Album L. in A Murine Model: A Reproductive Toxicity Study

Stimulation of Humoral and Cellular Immunity by Viscum Preparations

Recent Studies on the Anticancer Activities of Mistletoe <i>(Viscum album) </i>and Its Alkaloids

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