Thyroid antigen—Antibody nephritis

O’Regan, S; Fong, Jack S. C.; Kaplan, Bernard S.; Chadarévian, Jean‐Pierre de; Lapointe, Normand; Drummond, Keith N.

doi:10.1016/0090-1229(76)90087-8

Cited by 59 publications

(24 citation statements)

References 10 publications

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“…To date, only thyroglobulin has been demonstrated to stain positively in membranous nephropathy due to Graves' disease [3][4][5][6], and our present case and that from Shima et al are the only two that report staining for both the TPO antigen and the thyroglobulin antigen [7]. Interestingly, thyroglobulin and TPO antigen deposition in the kidneys has been previously reported in Hashimoto's disease; in these reports, deposits of both thyroglobulin and TPO antigens were seen with the fluorescent antibody technique [9,10]. In contrast, both our group and Shima et al [7] found only TPO antigen deposits, with no deposits of the thyroglobulin antigen in Graves' disease.…”

Section: Discussionsupporting

confidence: 74%

“…The use of PTU in treatment has also been reported as a cause of membranous nephropathy originating from Graves' disease [9], and cannot be excluded as a cause in the present case. Thiamazole has been administered for the treatment of membranous nephropathy originating from Graves' disease, but thiamazole and PTU failed to control the hyperthyroidism in our present patient and she was treated with 131 I treatment instead.…”

Section: Discussionmentioning

confidence: 64%

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Membranous nephropathy secondary to Graves’ disease with deposits of thyroid peroxidase in an adult

et al. 2013

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A 40-year-old woman was diagnosed with Graves' disease in 2001 and treated with thiamazole, but disease control was poor. She was referred to our hospital in 2011 for exacerbation of proteinuria, which had been present since 2006. Urinalysis showed a protein/creatinine ratio of 4.2 g/gCre and microhematuria, and a renal biopsy was performed. On electron microscopy, high electron density deposits were seen on the epithelial side of the glomerular basement membrane. IgG was also deposited along the glomerular loop wall, and membranous nephropathy was diagnosed. Immunostaining revealed thyroid peroxidase deposits but not thyroglobulin antigen deposits, suggesting that the membranous nephropathy was secondary to Graves' disease. The membranous nephropathy improved with 131 I treatment. To our knowledge, this is the first adult case of membranous nephropathy originating from Graves' disease in which deposits of thyroid peroxidase antigens have been detected.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 64%

Membranous nephropathy secondary to Graves’ disease with deposits of thyroid peroxidase in an adult

et al. 2013

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“…Graves' disease is often accompanied with renal dysfunction such as immune complex-mediated nephritis by thyroid antigens (5,6) and acute renal failure by rhabdomyolysis following thyroid crisis (7,8). During propylthiouracil treat-ment, there are cases reports of ANCA-related glomerulonephritis (9,10) and propylthiouracil-induced tubulointerstitial nephritis (11,12).…”

Section: Discussionmentioning

confidence: 99%

Thyroid Crisis following Interstitial Nephritis

et al. 2008

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“…12 Other laboratory abnormalities may include a mild elevation of liver aminotransferase levels; renal impairment has also been reported in a few cases of HE in the form of glomerulonephritis, and may be related to deposition of immune complexes containing thyroglobulin antigen. 6,[12][13][14] MRI of the brain is normal or nonspecific in most cases, and the EEG most commonly shows diffuse slowing. The differential for a rapidly progressive cognitive decline includes CJD, CNS vasculitis, paraneoplastic syndromes, and autoimmune and subacute infectious encephalopathies.…”

Section: Commentarymentioning

confidence: 99%