Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study)

Saki, Fatemeh; Dabbaghmanesh, Mohammad Hossein; Ghaemi, Seyede Zahra; Forouhari, Sedighe; Omrani, Gholamhossein Ranjbar; Bakhshayeshkaram, Marzieh

doi:10.3109/07435800.2014.966384

Cited by 32 publications

(24 citation statements)

References 32 publications

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“…All of the participants in our study were TPOAb negative, and we did not examine the relationship between TPOAb positive and adverse pregnancy outcomes, although some research has shown that TPOAb positive in early pregnancy is associated with an increased risk of GDM and preeclampsia [42, 43]. Another limit in this study is the lack of mechanism study for the metabolites role in hypothyroxemia and preeclampsia.…”

Section: Discussionmentioning

confidence: 93%

Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population

Zhang

Dai

et al. 2017

PLoS ONE

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Although thyroid dysfunction in early pregnancy may have adverse effects on pregnancy outcomes, few studies have examined the relationship between maternal low free thyroxin (FT4) levels in both first and third trimesters of pregnancy and the incidence of adverse pregnancy outcomes. We hypothesized that low FT4 levels in either first or third trimesters of pregnancy may have different effects on pregnancy outcomes. The study included 6,031 mothers who provided both first and third pregnancy serum samples for analyses of thyroid function. Adverse pregnancy outcomes, such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension and preeclampsia, were diagnosed using the oral glucose tolerance test, blood pressure and urine protein test. Serum metabolites like adenosine and its analogues were identified using hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry (MS/MS). The incidence of hypothyroidism in pregnant women tended to increase with age and pre-pregnancy body mass index (BMI). The incidence of GDM was negatively correlated with maternal FT4 levels during early pregnancy while the incidence of preeclampsia was negatively correlated with maternal FT4 levels during late pregnancy. The incidence of pregnancy-induced hypertension was not significantly correlated with maternal FT4 levels. The women who had isolated maternal hypothyroxemia (IMH) in the third trimester of pregnancy had an increased risk of developing preeclampsia. Some metabolites like adenosine and its analogues in the serum were significantly changed in pregnant mothers with IMH. In conclusion, low FT4 levels during pregnancy are a risk factor for GDM and preeclampsia. Adenosine and its analogues may be important bridges between IMH and preeclampsia.

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Section: Discussionmentioning

confidence: 93%

Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population

Zhang

Dai

et al. 2017

PLoS ONE

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“…Moreover, there is accumulating evidence that possibility of preeclampsia increases if biochemical hypothyroidism coexists with certain thyroid autoantibodies (8, 9). Studies on the prevalence of anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies indicate that thyroid autoimmunity significantly affects the well-being of the pregnant mother as well as the fetus independently of the thyroid dysfunction (10, 11). …”

Section: Introductionmentioning

confidence: 99%

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

et al. 2015

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Preeclampsia is an important cause of maternal and prenatal morbidity and mortality in the developing countries. Changes in thyroid function/antibodies profiles in preeclamptic women are controversial and were never investigated before in Sudan. A case–control study was conducted at Medani Hospital, Sudan, to investigate thyroid function/antibodies in preeclampsia. The sociodemographic, medical history was gathered using questionnaires. Thyroid hormones [thyroid-stimulating hormone (TSH), free tri-iodothyronine (T3), and free thyroxine (T4)] and anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) antibodies were measured using ELISA. The three groups [controls, mild, and severe preeclampsia (SP) (55 women in each arm)] were matched in age and parity. While median (interquartile range) of TSH was significantly lower, both free T3 and free T4 levels were significantly higher in women with preeclampsia than in the healthy controls. There was no significant difference in the TSH levels in women with MP and SP. In comparison with women with MP, women with SP had significantly higher levels of free T3 and significantly lower levels of free T4. While anti-TPO antibodies were significantly higher, anti-TG antibodies were significantly lower in women with preeclampsia. Likewise, anti-TPO antibodies were significantly higher and anti-TG antibodies were significantly lower in women with SP than in women with MP. In linear regression, preeclampsia was significantly associated with TSH (−0.675 IU/ml, P = 0.009), free T3 (0.977 pg/ml, P < 0.001), and free T4 (0.186 ng/dl, P < 0.001) levels. In contrast to anti-TG antibodies and TSH, Sudanese patients with preeclampsia had higher levels of T3 and T4 hormones and anti-TPO antibodies irrespective of parity, gestational age, and hemoglobin levels.

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“…Evidence has shown that 10% to 20% of pregnant mothers can be TPO and Tg antibody positive, yet in euthyroid status (25). In a study by Saki et al, 12.8% of Iranian pregnant female were positive for TPOAb (38).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Level, Thyroid Function, and Maternal Depression in Late Pregnancy

et al. 2018

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Background: Based on a possible association between thyroid function or serum 25-hydroxyvitamin D concentration and perinatal psychological symptoms, this study examined the potential link between antenatal depression and thyroid function or vitamin D level in the population of Shiraz city. Methods: This cross-sectional study was conducted on mothers, who were under prenatal care at a teaching hospital in Shiraz, during year 2015. Evaluation of depression was performed by the Edinburgh postnatal depression scale (EPDS). Eligible pregnant

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Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study)

Cited by 32 publications

References 32 publications

Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population

Maternal low thyroxin levels are associated with adverse pregnancy outcomes in a Chinese population

Thyroid Function/Antibodies in Sudanese Patients with Preeclampsia

Vitamin D Level, Thyroid Function, and Maternal Depression in Late Pregnancy

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