“…A review of 17 series published between 1957 and 2015, where overall cancer incidence in acromegaly was investigated, revealed 7723 patients with 708 cases of cancer, resulting in a mean cancer incidence of 10.8%, with percentages varying from 4.8 to 21.3% (12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28). Standardized incidence ratio (SIR) was available from 11 series, and in three of them, cancer incidence was not increased (12,18,28).…”