Thyroid cancer surgery in Germany

BackgroundIt is evident that the rate of thyroid cancer is increasing throughout the world. One reason is increased detection of preclinical small cancers. However, it is not clear whether the increase in thyroid cancer rate is reducing the extent of thyroid surgeries. The purpose of this study was to evaluate the thyroid cancer rate and analyze recent changes in the extent of thyroid cancer surgeries in Korea.MethodsAn observational study was conducted using data from Korea’s Health Insurance Review and Assessment Service (HIRAS) for thyroidectomy with/without neck dissection, with 228,051 registered patients between 2007 and 2011. Data were categorized by the extent of surgery: unilateral thyroidectomy without neck dissection (UT), bilateral thyroidectomy or radical thyroidectomy without neck dissection (TT), any thyroidectomy with unilateral selective neck dissection (SND), any thyroidectomy with unilateral modified radical neck dissection (MRND), any thyroidectomy with unilateral radical neck dissection (RND), and any thyroidectomy with bilateral neck dissection (BND). Annual rate difference for each surgery was analyzed with a linear by linear association.ResultsThe absolute numbers of total thyroid surgeries (UT+TT+SND+MRND+RND+BND) were increased from 28539 to 61481. The proportion of patients who underwent only thyroidectomy without neck dissection (UT+TT) decreased from 67.30% to 60.50%, whereas the proportion of patients who underwent neck dissection (SND+MRND+RND+BND) increased from 32.70% to 39.50% during the 5-year study period.ConclusionDespite the increase in rate of thyroid cancer due to earlier detection, increased rate of neck dissection was noted.

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“…And other proportions of surgeries between men and women were similar clinically. These results are in agreement with other reports [24] .…”

Section: Discussionsupporting

confidence: 94%

Increasing Thyroid Cancer Rate and the Extent of Thyroid Surgery in Korea

Sung

Park

et al. 2014

PLoS ONE

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“…Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy but its etiology remains largely unknown [2]. The genetic predisposition of PTC has been evaluated in pedigree studies, association studies and genome wide association study [3], [4], [5], [6], [7], [8]. A series of single nucleotide polymorphisms (SNPs) were found to be associated with the risk of PTC in studies with different designs and populations, which indicated that the genetic etiology of PTC was complicated, and the results needed further investigation in independent studies to confirm the associations with PTC risk.…”

Section: Introductionmentioning

confidence: 99%

Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis

Wei

Wang

et al. 2013

PLoS ONE

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BackgroundRs2910164, a Single nucleotide polymorphism (SNP) located in the precursor microRNA sequence of miR-146a, is the only MicroRNA sequence SNP studied in papillary thyroid cancer (PTC). Association studies had been performed in US and UK-Northern European populations, but results were inconsistence. This study evaluated the association between rs2910164 and the risk of PTC as well as benign thyroid tumor (BN), and examined the clinicopathological characteristics of PTC and BN for different genotypes.MethodsThis case-control study genotyped rs2910164 in 753 PTCs, 484 BNs and 760 controls in a Chinese Han population. Clinicopathological and genetic data were collected and compared. Multivariate logistic regression was performed to calculate adjusted odds ratios (ORs).ResultsThere were no differences in rs2910164 genotype distributions between the three groups. PTC cases with three genotypes (CC, CG, GG) had similar clinicopathological characteristics except the existence of “para-cancer” BN (PTC/BN, P = 0.006). PTC/BN patients were older (P = 0.009), and had smaller cancer lesions (P<0.001), lower serum thyrotropin levels (1.82±1.42 vs. 2.21±1.74, P = 0.04), and lower rates of level VI lymph node metastasis (20.8% vs. 52.7%, P<0.001) and lateral neck lymph node metastasis (11.5% vs. 23.0%, P = 0.011) compared with PTC only. Then we supposed a possible progression from BN to PTC which may involve rs2910164 in and performed a multivariate logistic regression analysis of PTC/BN and BN cases to determine risk factors of this progression. Results showed that the rs2910164 GG homozygote (OR = 2.25, 95% CI 1.22–4.14, P = 0.01) was the only risk factor in this study.ConclusionRs2910164 was not associated with increased risk of PTC and BN in Chinese patients, but may play a latent role in the transformation from BN to PTC.

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“…The calculated mortality rates can only be seen as a very good proxy for the true in-hospital mortality rates [ 28 ]. The DRG data is primarily collected for reimbursement.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, for HNC patients under palliative care, further research is needed why the patients are treated as inpatients and what has to be done that they profit from ambulatory palliative care in the future. The calculated mortality rates can only be seen as a very good proxy for the true in-hospital mortality rates [28]. The DRG data is primarily collected for reimbursement.…”

Section: Discussionmentioning

confidence: 99%

Mortality during In-Hospital Treatment for Head and Neck Cancer in Germany: A Diagnosis-Related Group-Based Nationwide Analysis, 2005–2018

Hermanns

Kouka

Guntinas‐Lichius

2022

Journal of Oncology

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Background. Data on in-hospital MR (IHMR) of head and neck cancer (HNC) are sparse. Methods. IHMR was determined in Germany between 2005 and 2018 using nationwide population-based diagnosis-related group (DRG) data of 1,090,596 HNC. Results. The overall average IHMR was 0.04 ± 0.02 . IHMR increased with older age to 0.04 ± 0.01 for patients of 65-79 years of age (relative risk [RR] in relation to patients of 35-49 years of age = 1.767 ; 95 % confidence interval CI = 1.040 to3.001) to a maximum of 0.07 ± 0.01 for patients of 80 years and older ( RR = 2.826 ; CI = 1.663 to 4.803). IHMR was the highest when no HNC-specific treatment, i.e., best supportive and palliative care, was applied ( 0.11 ± 0.01 ; RR in relation to tumor biopsy surgery = 7.241 ; CI = 3.447 to 5.211). IHMR was not different between surgery, radiotherapy, or chemotherapy/biologicals. Conclusions. IHMR did not change over time. Efforts are needed to decrease the IHMR for HNC.

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Thyroid cancer surgery in Germany

Cited by 13 publications

References 11 publications

Increasing Thyroid Cancer Rate and the Extent of Thyroid Surgery in Korea

Increasing Thyroid Cancer Rate and the Extent of Thyroid Surgery in Korea

Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis

Mortality during In-Hospital Treatment for Head and Neck Cancer in Germany: A Diagnosis-Related Group-Based Nationwide Analysis, 2005–2018

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