Thyroid carcinoma.A clinical and pathologic study of 125 cases

Frauenhoffer, Christopher M.; Patchefsky, Arthur S.; Çobanoğlu, Adnan

doi:10.1002/1097-0142(197906)43:6<2414::aid-cncr2820430637>3.0.co;2-3

Cited by 52 publications

(11 citation statements)

References 16 publications

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“…Our observation that patients with papillary carcinoma had a more favourable survival rate than patients with follicular carcinoma is in accordance with some (5,10,11,20,23,25), but not all (8, 19), earlier reports. The stepwise multivariate analysis suggested that follicular histology is a negative prognostic factor even if other variables are taken into account.…”

Section: Discussionsupporting

confidence: 93%

Survival and Prognostic Factors in Thyroid Carcinoma

Joensuu

Klemi

Paul

et al. 1986

Acta Radiologica: Oncology

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A multivariate analysis of prognostic factors and survival was carried out in a series of 200 patients with thyroid carcinoma. The cumulative survival rate corrected for intercurrent deaths was higher for papillary carcinoma than for follicular carcinoma both at 5 years (92% vs 74%) and at ten years (87% vs 66%) after the diagnosis. Seventeen of the eighteen patients with anaplastic carcinoma died within 24 months after the diagnosis. The most important independent prognostic factor in patients with papillary or follicular carcinoma, by multivariate analysis, was age at time of diagnosis, followed by tumor penetration beyond the thyroid capsule and follicular histologic type. When different types of treatment were included in the analysis, age at diagnosis still remained the most important prognostic factor. Misdiagnosed intercurrent deaths in the elderly did not explain the negative effect of age on survival.

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Section: Discussionsupporting

confidence: 93%

Survival and Prognostic Factors in Thyroid Carcinoma

Joensuu

Klemi

Paul

et al. 1986

Acta Radiologica: Oncology

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“…Fravenhofer et al in his study of 125 cases of thyroid cancer found that 80% of thyroid cancers in individuals under 40 years of age was papillary carcinoma. 14 In present study out of 70 cases 6 cases were of papillary variety and 2 cases were diagnosed as follicular variety accounting to a percentage of 75% and 25% respectively.…”

Section: Resultsmentioning

confidence: 57%

Prevalence of solitary thyroid nodule and evaluation of the risk factors associated with occurrence of malignancy in a solitary nodule of thyroid

Kishan

Prasad

2018

Int Surg J

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Background: A solitary nodule may become cosmetically distressing to a patient and occasionally causes pressure symptoms. Less frequently, an autonomously hyper functioning single nodule may cause hyperthyroidism. However, in the greater proportion of patients the major concern relates to the potential of malignancy with in such a nodule. Objective of present study was to study prevalence of solitary thyroid nodule and evaluate the risk factors associated with occurrence of malignancy in a solitary nodule of thyroid.Methods: This is a prospective study of randomly selected patients with clinically palpable, solitary thyroid nodule diagnosed and treated at Prathima Institute of Medical Sciences Karimnagar. Total duration of study was two years, from 2010 October to 2012 September.Results: The prevalence was found to be 19.2% in the present study. Majority were females i.e. 86.7%. It was found that maximum i.e. 36% of the cases belonged to the age group of 21-30 years. Swelling of the thyroid region was present in all cases. 97% of the patients were found to be euthyroid. FNAC showed that majority had follicular neoplasm. Hemi-thyroidectomy was the most common method used in 62 cases. Cytology diagnosis as Follicular neoplasm was the most common indication of surgery in 34 cases. Follicular adenoma was the most common histopathological finding in 43% of the cases. Benign lesion was the most common lesion in both males and females. Papillary cancer was the most common. The sensitivity of FNAC was found to be 94%.Conclusions: FNAC is the gold standard for evaluation of solitary thyroid nodules with an accuracy of 94% in our study. Females are more commonly affected than Males. 11.4% of Solitary Thyroid nodules were malignant. Suspect malignancy at extremes of age. Malignant potential of solitary thyroid nodule after 6th decade is 50%.

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“…There are two major types of intrathyroidal, low grade follicular carcinomas (FCs) and Hurthle cell carcinomas (HCs): widely invasive and minimally invasive (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The latter type forms a solitary lesion in the thyroid and is almost always encapsulated.…”

mentioning

confidence: 99%

Metastatic Minimally Invasive (Encapsulated) Follicular and Hurthle Cell Thyroid Carcinoma: A Study of 34 Patients

2000

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Most studies that have examined minimally invasive, encapsulated, follicular carcinoma (FC) or Hurthle cell carcinomas (HCs) have contained only a few metastatic neoplasms. We studied 34 patients with a single, minimally invasive, metastatic FC or HC and compared them with 38 patients with similar, nonmetastatic FCs or HCs. The numbers of incomplete capsular penetration (neoplasm into but not through the capsule), complete capsular penetration (neoplasm through the capsule), and vascular invasion foci were quantified. The median number (three), range, and distribution of complete capsular penetration and vascular invasion foci were similar in the nonmetastatic and metastatic carcinomas. All of the metastatic FCs and HCs had at least one vascular invasion or complete capsular penetration focus. Sixty-two percent of the metastatic carcinomas had two to four complete capsular penetration foci, and 60% had two to four vascular invasion foci. Two metastatic neoplasms had incomplete capsular penetration but had one and two vascular invasion foci, respectively. One tumor had no vascular invasion but had four complete capsular penetration foci. No metastatic neoplasms had incomplete capsular penetration only. There were no differences in the number of vascular invasion or complete capsular penetration foci between metastatic and nonmetastatic FCs and HCs and between metastatic FCs and HCs. Most metastatic neoplasms had vascular space invasion and complete capsular penetration. The number of complete capsular penetration or vascular invasion foci was not associated with the initial site of metastasis or the interval between the surgery and the metastasis.

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Thyroid carcinoma.A clinical and pathologic study of 125 cases

Cited by 52 publications

References 16 publications

Survival and Prognostic Factors in Thyroid Carcinoma

Survival and Prognostic Factors in Thyroid Carcinoma

Prevalence of solitary thyroid nodule and evaluation of the risk factors associated with occurrence of malignancy in a solitary nodule of thyroid

Metastatic Minimally Invasive (Encapsulated) Follicular and Hurthle Cell Thyroid Carcinoma: A Study of 34 Patients

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