Thyroid carcinoma producing β‐human chorionic gonadotropin shows different clinical behavior

Gu, Haiyan; Sui, Shaofeng; Cui, Xiujie; Han, Bo; Qi, Mei; Li, Congcong; Liu, Zhiyan

doi:10.1111/pin.12639

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…We found that BDE209 has the potential to induce biphasic responses in normal human thyroid follicular cells (Nthy-ori 3-1), which indicates that the promotion of cell proliferation is manifested only when the exposure dose is under a certain threshold, while above this threshold, it inhibits cell growth. This result is consistent with several experimental studies showing apparent nonmonotonic effects of BDE209 in various cell lines and organisms [ 28 , 29 , 30 , 31 ]. In consideration of the fact that an environmentally relevant serum concentration of BDE209 in humans has a low threshold, we focused mainly on the effects and mechanism of low concentrations of BDE209 on the thyroid [ 19 , 32 ].…”

Section: Discussionsupporting

confidence: 93%

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Wang

Cui

Zhao

et al. 2022

Cancers

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Polybrominated diphenyl ethers (PBDEs) have been reported to possess endocrine-disrupting and tumour-promoting activity. However, the effects of long-term exposure to decabromodiphenyl ether (BDE209) on thyroid tumourigenesis of papillary thyroid carcinoma (PTC) and the underlying mechanisms remain poorly defined. In this study, functional assays in vitro and mouse models in vivo were used to evaluate the toxic effects of long-term exposure to environmental concentrations of BDE209 on the pathogenesis and progression of PTC. MTS, EdU and colony-forming assays confirmed the chronic toxicity of BDE209 on the proliferation of human normal follicular epithelial cell line (Nthy-ori 3-1) and PTC-derived cell lines (TPC-1 and BCPAP). Wound and Transwell assays showed that BDE209 exacerbated the aggressiveness of PTC cells. BDE209 significantly promoted cell proliferation during the S and G2/M phases of the cell cycle. Mechanistically, BDE209 altered the thyroid system by acting as a competitive inhibitor of thyroid receptor beta (TRß) expression and function, which was further proven by public databases and RNA-seq bioinformation analysis. Taken together, these results demonstrated that BDE209 has chronic toxicity and potential tumourigenic effects on the thyroid by inhibiting TRß.

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Section: Discussionsupporting

confidence: 93%

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Wang

Cui

Zhao

et al. 2022

Cancers

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“…The latter can confuse the diagnostician, but the positivity for TTF1, PAX8, and thyroglobulin solves this quandary. Immunoreactivity for β-human chorionic gonadotropin was also reported in a case [10]. Unlike tall cell and classical variants, BRAF V600E mutation is relatively less common and has been reported in about one third of cases [8,11].…”

Section: Tumors With Predominant Papillary Growth Pattern Columnar Cementioning

confidence: 87%

Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers

2020

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Thyroid pathology encompasses a heterogenous group of clinicopathological entities including rare and diagnostically challenging neoplasms. The review is focused on morphological, immunohistochemical, and molecular features of rare thyroid neoplasms that can pose diagnostic problems. The tumors are organized based on growth patterns including thyroid neoplasms with predominantly papillary, follicular, solid, and spindle cell growth pattern, as well as neoplasms with distinct cytological characteristics. A special section is also dedicated to rare thyroid tumors with peculiar patterns including thyroid carcinoma with Ewing family tumor elements and intrathyroidal thymic-related neoplasms.

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“…Paraneoplastic manifestations have been reported in anaplastic thyroid carcinoma. The manifestations comprise ectopic secretion of human chorionic gonadotrophin (Gu et al 2018), fibroblastic growth factor 23 (giving rise to osteomalacia) (Abate et al 2016), granulocyte colonystimulating factor (give rise to leucocytosis) (Kang et al 2013), parathyroid hormone-related protein (give rise to hypercalcemia) (Iwai et al 2004) as well as hypertrophic osteoarthropathy likely to be the effect of secretion of platelet derived growth factor or vascular endothelial growth factor (Vico et al 1992). Similar to anaplastic thyroid carcinoma, paraneoplastic manifestations could occur in patients with primary squamous cell carcinoma of thyroid.…”

Section: Clinical Featuresmentioning

confidence: 99%

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

Lam

2020

Endocrine-Related Cancer

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The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.

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Thyroid carcinoma producing β‐human chorionic gonadotropin shows different clinical behavior

Cited by 6 publications

References 45 publications

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

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