Thyroid Carcinosarcoma in a Dog

Grubor, Branka; Haynes, Joseph S.

doi:10.1354/vp.42-1-84

Cited by 25 publications

(55 citation statements)

References 14 publications

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“…Embora comum nos gatos e cavalos e incomum nos cães, o adenoma folicular e papilar de tireoide é de grande importância na clínica médica, pois muitas vezes os mesmos se mostram funcionais, interferindo na produção dos hormônios tireoidianos (Capen, 2002;Grubor & Haynes, 2005;Soller et al, 2008). A interferência na produção desses hormônios afeta diretamente no metabolismo do animal, induzindo a outras patologias mais graves resultando em óbito do animal (Grubor & Haynes, 2005;Mooney, 2005).…”

Section: Discussionunclassified

“…As neoplasias da tireoide são descritas em cães, gatos e cavalos (Capen, 2002;Grubor & Haynes, 2005). No entanto, no cão representam de 1 a 2% de todas as neoplasias, sendo 10 a 15% de todas as neoplasias primárias benignas da região da cabeça e do pescoço (Peterson, 2003).…”

Section: Introductionunclassified

“…De acordo com Capen (2002), Grubor & Haynes (2005), as neoplasias da tireoide podem surgir a partir dos cinco anos de idade, sendo a idade média dos animais reportados com adenomas da tireoide variando entre 11 a 13 anos e os adenocarcinomas entre 9 e 16 anos. As raças mais acometidas são: Boxer, Beagle, Golden Retriever, Labrador e Pastor Alemão (Pack et al, 2001;Slensky et al, 2003;Alleman, 2003;Barber, 2007).…”

Section: Introductionunclassified

“…Os sinais clínicos presentes nos animais acometidos com esse tipo de neoplasia são: neoformação na região do pescoço, dificuldade respiratória e deglutição devido à compressão ou o deslocamento da traqueia e do esôfago pela neoplasia (Slensky et al, 2003;Mooney, 2005;Grubor & Haynes, 2005;Barber, 2007).…”

Section: Introductionunclassified

“…A probabilidade de metástases é diretamente proporcional com o tamanho da neoplasia (Fossum, 2002;Grubor & Haynes, 2005;Mooney, 2005). Visto que os adenomas papilares da tireoide são pouco comuns em cães com idade inferior a 10 anos e com um prognóstico variável quando submetidos somente a excisão cirúrgica, o objetivo do trabalho é relatar um caso de adenoma papilar cístico não funcional de tireoide em um cão submetido ao tratamento cirúrgico sem associação aos tratamentos adjuvantes.…”

Section: Introductionunclassified

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Thyroid papillary cist adenoma in dog (Canis familiaris)

Santos¹,

Cardoso

Brombini

et al. 2014

AVB

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RESUMO -Os adenomas da tireoide não são comuns em cães, sendo na maioria das vezes identificados na necropsia como um achado acidental. São neoplasias que acometem animais com idade entre 11 e 13 anos. O trabalho teve como objetivo relatar o tratamento cirúrgico, sem associação a nenhum tratamento adjuvante, de adenoma papilar cístico não funcional de tireoide, de 8 cm de comprimento e 6 cm de largura, em um cão da raça Labrador, com quatro anos de idade, atendido no Hospital Veterinário Escola, Moçambique. Os exames complementares de imagem (radiografia e ultrassonografia), hemograma, bioquímica sérica, dosagem hormonal e aspiração com agulha fina (CAAF), não foram conclusivos para o diagnóstico definitivo. Contudo, o exame histopatológico foi determinante para o diagnóstico definitivo, sendo que o tratamento por excisão cirúrgica completa, sem associação a quimioterapia, foi eficaz no presente caso.Palavras-Chave: Glândula endócrina, neoplasia, cirurgia, cisto. ABSTRACT -The thyroid adenomas are not common in dogs, and the majority of cases are identified at necropsy as an accidental finding. These neoplasias affect dogs with age between 11 and 13 years old. The aim of this work was to report the surgical treatment, with no association to any adjuvant treatment, of non functional thyroid papillary cist adenoma with 8 cm in length and 6 cm in width, in a dog, Labrador breed, with four years old, attended at the Veterinary Hospital School, Mozambique. The complementary exams as image (X-ray and ultrasound), complete blood count, serum biochemistry, hormonal dosage and fine-needle aspiration (FNA), were not conclusive for the diagnosis. However, the histopathology exam was crucial for the definitive diagnosis, and the treatment by complete surgical resection, without association with chemotherapy, was effective in this case.

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Section: Discussionunclassified

Section: Introductionunclassified

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Thyroid papillary cist adenoma in dog (Canis familiaris)

Santos¹,

Cardoso

Brombini

et al. 2014

AVB

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Clinical outcomes of thyroid tumours with concurrent epithelial and mesenchymal components in 14 dogs (2006–2020)

Cook

Gaspirini

Cianciolo

et al. 2022

Veterinary Medicine & Sci

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Background While rare, multiple individual case reports have described mixed thyroid tumours in dogs containing both epithelial and mesenchymal neoplastic components. Objectives In this retrospective case series, we describe the clinical presentation, treatment and outcome of 14 dogs of canine thyroid tumours with concurrent mesenchymal and epithelial neoplastic populations. Methods Fourteen cases were retrospectively abstracted from nine institutions. Histopathologic samples and reports were collected from 10/14 dogs and reviewed by a single board‐certified anatomic pathologist. Results All 14 dogs had curative‐intent surgery to remove the thyroid neoplasm. The most common surgery performed was a unilateral thyroidectomy (10/14 dogs). Postoperatively, systemic therapy was administered in eight dogs. Six dogs developed local recurrence with a median time to loco‐regional recurrence of 53 days. Ten dogs developed metastatic disease with the most common metastatic site being the lungs (6/10 dogs), with a median time to metastasis of 93 days. Ten dogs were euthanised due to locoregional or distant progression of their mixed thyroid neoplasm. The overall median survival time was 156 days (95%CI: 49–244). The median survival time for dogs treated with adjuvant therapy was 189 days (95%CI: 24–244), whereas dogs without adjuvant therapy had a median survival time of 156 days (95%CI: 35‐upper limit could not be calculated; p = 0.62). Conclusion The thyroid tumours with both mesenchymal and epithelial components in this small sample set were associated with a poor prognosis after surgical excision with or without adjunctive therapy.

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