Thyroid dysfunction in adult patients late after autologous and allogeneic blood and marrow transplantation

Sánchez-Ortega, Isabel; Canals, Carmen; Peralta, Teresa; Parody, Rocío; Clapés, V; Sevilla, Alberto Fernández de; Duarte, Rafael F.

doi:10.1038/bmt.2011.54

Cited by 14 publications

(11 citation statements)

References 8 publications

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“…Overall overt or subclinical hypothyroidism occurred more frequently in female than male patients (42.9% vs. 24.2%), with statistical significance, and odds ratio of 2.34. So, in our study female gender was a predictor for the occurrence of ATF after HSCT, which was not the case in two previous studies [4,7]. The incidence of ATF in our study was more in allogenic group with odds ratio of 2.05 and significant P value, which is contradicting the result of the study by Sanchez-O, et al (7).…”

Section: Discussioncontrasting

confidence: 57%

“…So, in our study female gender was a predictor for the occurrence of ATF after HSCT, which was not the case in two previous studies [4,7]. The incidence of ATF in our study was more in allogenic group with odds ratio of 2.05 and significant P value, which is contradicting the result of the study by Sanchez-O, et al (7). This might be due to shorter follow up time in our study, since in Sanchez-O study the median follow up was 39 months, with 25% developing it between 7-14 years.…”

Section: Discussionsupporting

confidence: 45%

“…However, fewer studies have analyzed the incidence of this complication in adults [4][5][6], in particular after autologous HSCT [4], these studies showed 3-year cumulative incidence of ATF ranges between 8-23%. The risk factors for ATF after HSCT is not consistent in all studies, some studies showed TBI as a significant predictor [1], other studies showed the only significant predictor is the type of transplant, with higher incidence in autologus transplant compared to allogenic transplant [7]. We aimed in this study to find the incidence of ATF after HSCT at our center, and to study the significance of different factors for its occurrence.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and Predicting Factors for Abnormal Thyroid Function Test in Adult Patients Post Hematopoietic Stem Cell Transplantation at King Hussein Cancer Center

Younis¹

2016

JED

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

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Incidence and Predicting Factors for Abnormal Thyroid Function Test in Adult Patients Post Hematopoietic Stem Cell Transplantation at King Hussein Cancer Center

Younis¹

2016

JED

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“…Thyroid abnormalities are well-described after BMT [38][39][40][41][42][43] and include compensated hypothyroidism (elevated TSH accompanied with normal FT4 levels) and overt hypothyroidism (elevated TSH and low FT4). Approximately 30% of patients develop overt hypothyroidism over a 28-year follow-up period.…”

Section: Discussion Of Patientmentioning

confidence: 99%

How I monitor long-term and late effects after blood or marrow transplantation

Bhatia

Armenian

Landier

2017

Blood

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Blood or marrow transplantation (BMT) is used with curative intent for hematologic malignancies. Conditional on surviving the first 2 years after BMT, 5-year survival generally exceeds 70%. However, the cumulative therapeutic exposures lead to premature onset of chronic health conditions, such that the 15-year cumulative incidence of severe or life-threatening chronic health conditions exceeds 40%, resulting in premature mortality. The high burden of morbidity, coupled with a long latency between BMT and the development of chronic health conditions necessitates life-long risk-based monitoring of the BMT survivors. The issues of how and when to screen BMT survivors for therapyrelated complications and exacerbation of preexisting conditions are important and largely unanswered questions. For BMT survivors, screening recommendations must incorporate risks associated with pre-BMT therapy as well as risks related to transplant conditioning and graft-versus-host disease. Here, we describe our approach to monitoring BMT survivors for risk-based screening and early detection of key late-occurring or long-term complications using patient scenarios to illustrate our discussion. (Blood. 2017;130(11):1302-1314

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“…These survivors are at an increased risk for thyroid dysfunction, gonadal dysfunction, growth impairments and bony abnormalities [44,45,46,47,48]. As highlighted earlier, gonadal dysfunction occurs in both males and females exposed to chemotherapy and/or radiation, and with this particular age group this is an important area of focus.…”

Section: Late Effectsmentioning

confidence: 99%

Hematopoietic Stem Cell Transplantation in Adolescents and Young Adults

Tewari

Franklin²,

Tarek

et al. 2014

Acta Haematol

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Background: Adolescents and young adults (AYAs) are a very unique subset of our population journeying through a dynamic stage of their lives. This age group often remains understudied as a separate entity because they are commonly lumped into either pediatric or adult subgroups. Methods: Here we review acute and chronic issues surrounding hematopoietic stem cell transplantation (HSCT) with a focus on the AYA age group. Results: HSCT is a commonly used treatment modality for patients with certain types of cancers. AYA patients undergoing HSCT present a very unique perspective, circumstances, medical, psychological and social issues requiring a diligent workup, care and follow-up. Conclusion: The medical care of these patients should be approached in a multidisciplinary method involving the patient, caregivers, physicians, psychologists and social workers.

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Thyroid dysfunction in adult patients late after autologous and allogeneic blood and marrow transplantation

Cited by 14 publications

References 8 publications

Incidence and Predicting Factors for Abnormal Thyroid Function Test in Adult Patients Post Hematopoietic Stem Cell Transplantation at King Hussein Cancer Center

Incidence and Predicting Factors for Abnormal Thyroid Function Test in Adult Patients Post Hematopoietic Stem Cell Transplantation at King Hussein Cancer Center

How I monitor long-term and late effects after blood or marrow transplantation

Hematopoietic Stem Cell Transplantation in Adolescents and Young Adults

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