Thyroid Gland Involvement in Carcinoma Larynx and Hypopharynx-Predictive Factors and Prognostic Significance

Iype, Elizabeth Mathew; Jagad, Vijay; Nochikattil, Santhosh Kumar; Varghese, Bipin T.; Stolzmann, Paul

doi:10.7860/jcdr/2016/15225.7310

Cited by 9 publications

(16 citation statements)

References 10 publications

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“…Among these factors, the most commonly accepted is the subglottic extension of more than 1 cm. [2][3][4][5][6][7][8][9][10][11][12] On the other hand, an important issue is to perform central neck dissection in locally advanced laryngeal carcinoma for preventing locoregional recurrences. Prelaryngeal, pretracheal and paratracheal lymph nodes are in proximity to the thyroid gland.…”

Section: Discussionmentioning

confidence: 99%

Incidence of thyroid gland invasion in locally advanced laryngeal carcinoma

Doğan¹

2018

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Objectives: This study aims to determine the frequency of thyroid gland invasion in patients with locally advanced laryngeal carcinoma who were treated with total laryngectomy and neck dissection as well as hemi-or total thyroidectomy. Patients and Methods: Between April 2000 and February 2016, 127 patients (123 males, 4 females; mean age 57 years; range, 41 to 74 years) who underwent total laryngectomy and neck dissection with laryngeal squamous cell carcinoma were retrospectively reviewed in our clinic. Patients' demographic characteristics, preoperative tumor stage, postoperative laryngectomy pathology report, tumor invasion, neck lymph node invasion and thyroid gland invasion were evaluated. Results: In 127 patients, 43 with subglottic extension, extralaryngeal extension and cricothyroid membrane invasion underwent total or hemithyroidectomy in addition to laryngectomy and neck dissection. Squamous cell carcinoma infiltration was found in one patient (2.3%) in the thyroid gland. This patient was diagnosed as T4N1M0 in the pathological stage. Thyroid cartilage invasion and subglottic extension were detected in the preoperative evaluation. Conclusion: Thyroidectomy is performed in our clinic only when subglottic extension, extralaryngeal invasion or cricothyroid membrane invasion is present. Hence, thyroid gland invasion is not common in carcinoma of the larynx. For this reason, we recommend selective thyroidectomy to protect patients from the morbidity of routine thyroidectomy.

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Section: Discussionmentioning

confidence: 99%

Incidence of thyroid gland invasion in locally advanced laryngeal carcinoma

Doğan¹

2018

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“…1 A retrospective study by Iype et al showed 30% increase in thyroid gland invasion among patients with pre-operative findings of thyroid cartilage erosion by CT scan. 16 In our study, there were 11 cases with thyroid cartilage invasion confirmed through histopathology, all of which were transglottic tumors. Among these, only one had positive thyroid gland invasion, increasing the risk to 9.1% or 1 out of 11.…”

Section: Discussionmentioning

confidence: 66%

Thyroid Gland Invasion in Laryngeal Carcinoma

Vitamog¹,

Castañeda²

2018

Philipp J Otolaryngol Head Neck Surg

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Objective: To determine the prevalence of, and describe transglottic cancer with thyroid cartilage invasion as a possible risk for, thyroid gland invasion in a series of patients with laryngeal carcinoma who underwent total laryngectomy with thyroidectomy. Methods Study Design: Retrospective case series Setting: Tertiary government hospital Subjects: 61 laryngeal carcinoma patients who underwent total laryngectomy with hemi- or total thyroidectomy from January 2010 to August 2017. Results Out of 61 patients with laryngeal carcinoma, 11 patients had supraglottic, 11 glottic, 2 subglottic and 37 had transglottic involvement. Eleven had thyroid cartilage invasion, all of whom had transglottic tumors. Of these 11 patients, only 1 had thyroid gland invasion. This was a case of a 78 year-old male patient, with poorly differentiated SCC stage IVa transglottic tumor with thyroid cartilage invasion. Conclusion Thyroid gland invasion was uncommon in our sample of laryngeal carcinoma patients who underwent laryngectomy and thyroidectomy. Although transglottic involvement with thyroid cartilage invasion may increase the risk of thyroid gland invasion, it could not be confirmed by our series. Perhaps thyroidectomy should not be routinely performed on all patients with laryngeal carcinoma who undergo total laryngectomy, but more rigorous studies are needed to establish this. Keywords: laryngeal carcinoma, transglottic, thyroid cartilage invasion, thyroid gland invasion, thyroidectomy

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“…TThy with bilateral paratracheal and pretracheal lymph node dissection is warranted when there is direct tumor involvement of the TG. 10,16,17,20,21 Although National Comprehensive Cancer Network (NCCN) guidelines describe that thyroidectomy is indicated in T3 and T4a carcinoma of the larynx, they do not state whether HTyh or TThy should be performed in SL. 22 One could argue that TThy should be performed for all SL cases where there is TGI as this is associated with a poor prognosis and local recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

Brunet

Tornari

Ezebuiro

et al. 2021

Otolaryngol.--head neck surg.

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Objective Management of recurrent laryngeal cancer presents a major challenge, and salvage laryngectomy is complicated by previous oncologic treatments. Thyroidectomy as part of salvage laryngectomy adds a nonnegligible degree of morbidity. The purpose of this study is to assess the rate of thyroid gland invasion in patients undergoing salvage laryngectomy to determine relevant predictive factors. Study Design Case series with chart review. Setting Department of Otorhinolaryngology, Head and Neck Surgery, Guy’s Hospital, London, United Kingdom. Methods A retrospective review of patients undergoing salvage laryngectomy between 2009 and 2019 was undertaken. Preoperative cross-sectional imaging and histopathological analysis were performed to define evidence and predictors of thyroid gland invasion (TGI). Results Fifty-one patients had salvage laryngectomy. Histological evidence of TGI was found in 4 patients (7.8%). No significant relationship was found between histological TGI and subsite of primary carcinoma, degree of differentiation, T staging, or radiological TGI. Preoperative computed tomography had a high negative predictive value for TGI. Conclusion Thyroidectomy should be carefully considered in patients undergoing salvage laryngectomy, and its extent should be defined on an individual basis. Total thyroidectomy should not routinely be performed in salvage laryngectomy or pharyngolaryngectomy in patients with no preoperative radiological evidence of TGI on cross-sectional imaging, unless there is intraoperative evidence of TGI.

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Thyroid Gland Involvement in Carcinoma Larynx and Hypopharynx-Predictive Factors and Prognostic Significance

Cited by 9 publications

References 10 publications

Incidence of thyroid gland invasion in locally advanced laryngeal carcinoma

Incidence of thyroid gland invasion in locally advanced laryngeal carcinoma

Thyroid Gland Invasion in Laryngeal Carcinoma

Role of Thyroidectomy in Recurrent Laryngeal Carcinoma

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