2023
DOI: 10.3389/fendo.2023.1090081
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Thyroid hormone action controls multiple components of cell junctions at the ventricular zone in the newborn rat brain

Abstract: Thyroid hormone (TH) action controls brain development in a spatiotemporal manner. Previously, we demonstrated that perinatal hypothyroidism led to formation of a periventricular heterotopia in developing rats. This heterotopia occurs in the posterior telencephalon, and its formation was preceded by loss of radial glia cell polarity. As radial glia mediate cell migration and originate in a progenitor cell niche called the ventricular zone (VZ), we hypothesized that TH action may control cell signaling in this … Show more

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Cited by 10 publications
(7 citation statements)
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“…Our method includes additional downstream metabolites, rT3, 3,3′-T2 and 3-T1; of these, rT3 and 3,3′-T2 concentrations were measured in all samples. No difference in TH concentration in the brain was observed between male and female rats at any examined age, which is in line with the available literature [ 9 , 17 , 18 ]. From PND4 to PND21, an increase in T4, T3 and T2 concentrations and a decrease in rT3 concentration were detected in the brain.…”
Section: Discussionsupporting
confidence: 91%
“…Our method includes additional downstream metabolites, rT3, 3,3′-T2 and 3-T1; of these, rT3 and 3,3′-T2 concentrations were measured in all samples. No difference in TH concentration in the brain was observed between male and female rats at any examined age, which is in line with the available literature [ 9 , 17 , 18 ]. From PND4 to PND21, an increase in T4, T3 and T2 concentrations and a decrease in rT3 concentration were detected in the brain.…”
Section: Discussionsupporting
confidence: 91%
“…The relative expression levels of gene targets previously identified in the PVH-forming region and ventricular epithelium of the PTU-exposed PN6 neonatal brain [ 4 , 5 ] were not changed by perchlorate at any dose level ( Figure 4 ). The lack of an effect of perchlorate on gene expression in the PVH-forming region, although failing to support the anatomical observations, are consistent with the minor size of PVH when present, the relative crudeness of the dissection of the region, and the limited postnatal serum and brain T4 reductions evident in offspring from perchlorate-exposed dams.…”
Section: Resultsmentioning
confidence: 95%
“…In the rat, we previously reported the presence of a periventricular heterotopia (PVH), a cluster of ectopic neurons in the posterior forebrain of animals born to hypothyroid dams. This malformation is reliably induced by exposure to the pharmaceuticals propylthiouracil (PTU) and methimazole (MMI) in our laboratory and others [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Additionally, its size is dose-dependently aligned with declines in serum T4, and once formed, a PVH remains in the brain for the life of the animal [ 1 , 2 , 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The neuroepithelium of 2.5-week-old hCOs is the precursor structure of the cortical VZ containing RGC as the major neuronal stem cell population. The observation that, at least in rodent experimental studies, maternal hypothyroidism has been linked to perturbed RGC function 73 75 warrants further studies to verify the actual onset of functional TRα protein expression in the VZ.…”
Section: Discussionmentioning
confidence: 99%