Thyroid Hormone Effects on β-Adrenergic Receptors in Isolated Fat Cells of Rats

Pfeifle, Beate; Pfeifle, R.; Faulhaber, J.-D.; Ditschuneit, H.

doi:10.1055/s-2007-1019225

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Although not in CNS, but with potential relevance, THs in isolated fat cells were found to increase binding of 3 H-norepinephrine or 3 H-isoproterenol, the β-adrenergic agonist ( 91 ). T3 was more effective than T4.…”

Section: Th and Metabolite Binding In Brainmentioning

confidence: 99%

Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?

Martin,

Sarkar

2023

Front. Endocrinol.

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We review the evidence regarding the nongenomic (or non-canonical) actions of thyroid hormones (thyronines) and their derivatives (including thyronamines and thyroacetic acids) in the adult brain. The paper seeks to evaluate these compounds for consideration as candidate neurotransmitters. Neurotransmitters are defined by their (a) presence in the neural tissue, (b) release from neural tissue or cell, (c) binding to high-affinity and saturable recognition sites, (d) triggering of a specific effector mechanism and (e) inactivation mechanism. Thyronines and thyronamines are concentrated in brain tissue and show distinctive patterns of distribution within the brain. Nerve terminals accumulate a large amount of thyroid hormones in mature brain, suggesting a synaptic function. However, surprisingly little is known about the potential release of thyroid hormones at synapses. There are specific binding sites for thyroid hormones in nerve-terminal fractions (synaptosomes). A notable cell-membrane binding site for thyroid hormones is integrin αvβ3. Furthermore, thyronines bind specifically to other defined neurotransmitter receptors, including GABAergic, catecholaminergic, glutamatergic, serotonergic and cholinergic systems. Here, the thyronines tend to bind to sites other than the primary sites and have allosteric effects. Thyronamines also bind to specific membrane receptors, including the trace amine associated receptors (TAARs), especially TAAR1. The thyronines and thyronamines activate specific effector mechanisms that are short in latency and often occur in subcellular fractions lacking nuclei, suggesting nongenomic actions. Some of the effector mechanisms for thyronines include effects on protein phosphorylation, Na+/K+ ATPase, and behavioral measures such as sleep regulation and measures of memory retention. Thyronamines promptly regulate body temperature. Lastly, there are numerous inactivation mechanisms for the hormones, including decarboxylation, deiodination, oxidative deamination, glucuronidation, sulfation and acetylation. Therefore, at the current state of the research field, thyroid hormones and their derivatives satisfy most, but not all, of the criteria for definition as neurotransmitters.

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Section: Th and Metabolite Binding In Brainmentioning

confidence: 99%

Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?

Martin,

Sarkar

2023

Front. Endocrinol.

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“…Acreditamos que o tratamento com T3 na dose fisiológica poderia ter promovido uma reversão parcial do quadro, caso o tratamento fosse prolongado. Já, a perda de peso observada no grupo tratado com doses supra-fisiológicas de T3 era esperada, em função dos efeitos catabólicos do hormônio sobre o metabolismo proteico e lipídico (LEWIS;LEFKOWITZ, 1977;MULLER;SEITZ, 1984;PFEIFLE et al, 1981;RUBIO et al, 1995). (ARNER et al, 1990;PALOU et al, 2010;PORTILLO et al, 2000).…”

Section: C)unclassified

Efeitos dos hormônios tireoidianos sobre a regulação da expressão de proteínas envolvidas com a lipólise no tecido adiposo branco subcutâneo e visceral.

Silva¹

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Direct effect of triiodothyronine on glucose utilization in adipocytes from obese and nonobese zucker rats

Rifici

Kaplan

1984

International Journal of Biochemistry

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Thyroid Hormone Effects on β-Adrenergic Receptors in Isolated Fat Cells of Rats

Cited by 7 publications

References 6 publications

Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?

Nongenomic roles of thyroid hormones and their derivatives in adult brain: are these compounds putative neurotransmitters?

Efeitos dos hormônios tireoidianos sobre a regulação da expressão de proteínas envolvidas com a lipólise no tecido adiposo branco subcutâneo e visceral.

Direct effect of triiodothyronine on glucose utilization in adipocytes from obese and nonobese zucker rats

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