Thyroid hormone receptor beta: Relevance in human health and diseases

Rehman, Ghausiya; Kumari, Neha; Bano, Farhad; Tyagi, Rakesh K.

doi:10.1016/j.endmts.2023.100144

Cited by 10 publications

(1 citation statement)

References 213 publications

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“…The impact of arsenic on thyroid hormones is significant, as it predominantly affects the thyroid gland and its associated physiological processes, leading to alterations in hormone levels and functioning within the body. Arsenic, a metalloid with hazardous properties, possesses the capacity to interfere with the normal physiological processes of the thyroid gland [69]. The compound possesses the capacity to hinder the assimilation of iodine, a vital ingredient necessary for the synthesis of thyroid hormones.…”

Section: Effects Of Salvia Hispanica Seeds Powder On Thyroid Hormone ...mentioning

confidence: 99%

Evaluation of Salvia hispanica as a Therapeutic Agent against Sodium Arsenic-Induced Testicular Toxicity in a Male Rats Model

Omar,

Zahran,

Alhotan

et al. 2024

Life

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Chia seeds offer therapeutic properties that aid in the prevention of a variety of ailments, including cardiovascular disease, diabetes, obesity, and other risk factors. Arsenite, a common environmental chemical, has been identified as a reproductive toxin owing to its negative effects on male reproductive health. It has been shown to inhibit spermatogenesis and generate androgenic effects in men. The primary goal of this research was to look into the effect of Salvia hispanica on testicular toxicity caused by sodium arsenite in male rats. A set of 36 male albino rats was allocated to a negative control cohort. The individuals in this group were given a basic meal and orally given distilled water for a duration of 28 days. The other five groups were given a regular meal and received intra-peritoneal injections of sodium arsenite (NaAsO2) at a concentration of 4 mg/kg body weight that was diluted in a 0.9% NaCl solution. The injections were administered consecutively, with two doses given within a two-day period. Subsequently, the rats were categorized into several groups using the following classification: Group 2 consisted of a positive control cohort, in which the rats were given a typical baseline diet. Groups 3, 4, 5, and 6 were given a basic diet that included varying proportions of ground chia seeds, namely 5%, 10%, 15%, and 20% per 100 g of the diet. After the trial was completed, the rats were euthanized, and further biological examination was conducted. The measurements of the reproductive organs were documented and reported. The research assessed the following characteristics: sperm count, motility, progressive motility, and normal morphology. The research included examining serum sex hormones, namely luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone. An evaluation of the activity of antioxidant enzymes was performed in the tissue of the testicles. There were statistically significant improvements in the sperm parameters, serum sex hormone levels, and the activity of antioxidant enzymes, such as GPX, SOD, and CAT, in the therapy groups. The levels of malondialdehyde (MDA) exhibited a noteworthy decrease (p ≤ 0.05) when compared to the positive control group. Salvia hispanica seeds have demonstrated a significant level of effectiveness in reducing sodium arsenite-induced testicular toxicity, which leads to the conclusion. The flavonoid content and antioxidant properties of Salvia hispanica seeds may be to blame for the observed behavior. These indicated characteristics may have therapeutic significance in treating testicular harm induced by arsenite exposure.

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Section: Effects Of Salvia Hispanica Seeds Powder On Thyroid Hormone ...mentioning

confidence: 99%